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(+/-)-尼古丁

(+/-)-尼古丁用途

【用途一】
用于生化研究及园艺杀虫剂。

(+/-)-尼古丁名称

[ CAS 号 ]:
22083-74-5

[ 中文名 ]:
(+/-)-尼古丁

[ 英文名 ]:
(±)-nicotine

[中文别名 ]:

[英文别名 ]:

(+/-)-尼古丁物理化学性质

[ 密度 ]:
1.0±0.1 g/cm3

[ 沸点 ]:
244.4±28.0 °C at 760 mmHg

[ 熔点 ]:
-79ºC

[ 分子式 ]:
C10H14N2

[ 分子量 ]:
162.232

[ 闪点 ]:
101.7±0.0 °C

[ 精确质量 ]:
162.115692

[ PSA ]:
16.13000

[ LogP ]:
0.72

[ 外观性状 ]:
liquid | yellow

[ 蒸汽压 ]:
0.0±0.5 mmHg at 25°C

[ 折射率 ]:
1.539

[ 储存条件 ]:
Refrigerator

[ 水溶解性 ]:
ethanol: 50 mg/mL

(+/-)-尼古丁毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :
QS5257500
CHEMICAL NAME :
Nicotine, (+-)-
CAS REGISTRY NUMBER :
22083-74-5
BEILSTEIN REFERENCE NO. :
0082111
LAST UPDATED :
199612
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C10-H14-N2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
31250 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 50,93,1934
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
25 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 50,93,1934
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Mammal - cat
DOSE/DURATION :
2 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 50,93,1934
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
15 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 50,93,1934

(+/-)-尼古丁安全信息

[ 符号 ]:

GHS06, GHS09

[ 信号词 ]:
Danger

[ 危害声明 ]:
H301-H310-H411

[ 警示性声明 ]:
P273-P280-P301 + P310-P302 + P350-P310

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
T+: Very toxic;N: Dangerous for the environment;

[ 风险声明 (欧洲) ]:
25-27-51/53

[ 安全声明 (欧洲) ]:
36/37-45-61

[ 危险品运输编码 ]:
UN 1654 6.1/PG 2

[ WGK德国 ]:
3

[ RTECS号 ]:
QS5257500

(+/-)-尼古丁合成路线

(+/-)-尼古丁上下游产品

(+/-)-尼古丁制备

【方法一】
将烟叶和石灰石一起蒸馏后,再以乙醚萃取而得。

(+/-)-尼古丁文献

Effects of environmental enrichment on ERK1/2 phosphorylation in the rat prefrontal cortex following nicotine-induced sensitization or nicotine self-administration.

Eur. J. Neurosci. 41(1) , 109-19, (2015)

Rats raised in an enriched condition (EC) exhibit alterations in the neurobiological and behavioral response to nicotine compared with rats reared in an impoverished condition (IC) or a standard condi...

Effects of maternal nicotine exposure on thyroid hormone metabolism and function in adult rat progeny.

J. Endocrinol. 224(3) , 315-25, (2015)

Postnatal nicotine exposure leads to obesity and hypothyroidism in adulthood. We studied the effects of maternal nicotine exposure during lactation on thyroid hormone (TH) metabolism and function in a...

A critical role for the melanocortin 4 receptor in stress-induced relapse to nicotine seeking in rats.

Addict. Biol. 20(2) , 324-35, (2015)

Tobacco addiction is characterized by a lack of control over smoking and relapse after periods of abstinence. Smoking cessation leads to a dysphoric state that contributes to relapse to smoking. After...


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公司名:上海化源世纪贸易有限公司

区域:上海市普陀区

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联系人:徐经理

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标题:(+/-)-尼古丁_用途_密度_熔点_CAS号【22083-74-5】_化源网 地址:https://www.chemsrc.com/amp/cas/22083-74-5_599872.html