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细胞松驰素 C

细胞松驰素 C用途

Cytochalasin C 是一种细胞渗透性真菌毒素,能诱导核小棒的形成。Cytochalasin C 在小鼠中的毒性比 Cytochalasin D 低 10 倍。

细胞松驰素 C名称

[ CAS 号 ]:
22144-76-9

[ 中文名 ]:
细胞松弛素 C

[ 英文名 ]:
Cytochalasin C

[中文别名 ]:

[英文别名 ]:

EINECS 244-803-6
Cytochalasin C from Metarrhizium anisopliae
MFCD00066080

细胞松驰素 C生物活性

[ 描述 ]:

Cytochalasin C 是一种细胞渗透性真菌毒素,能诱导核小棒的形成。Cytochalasin C 在小鼠中的毒性比 Cytochalasin D 低 10 倍。

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

[参考文献]

[1]. Foissner I, et al. Wide-ranging effects of eight cytochalasins and latrunculin A and B on intracellular motility and actin filament reorganization in characean internodal cells. Plant Cell Physiol. 2007 Apr;48(4):585-97.

[2]. Yahara I, et al. Correlation between effects of 24 different cytochalasins on cellular structures and cellular eventsand those on actin in vitro. J Cell Biol. 1982 Jan;92(1):69-78.

[3]. Trendowski M, et al. Tolerated doses in zebrafish of cytochalasins and jasplakinolide for comparison with tolerateddoses in mice in the evaluation of pre-clinical activity of microfilament-directed agents in tumormodel systems in vivo. In Vivo. 2014 Nov-Dec;28(6):1021-31.

细胞松驰素 C物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
714.3±60.0 °C at 760 mmHg

[ 熔点 ]:
260-264ºC

[ 分子式 ]:
C₃₀H₃₇NO₆

[ 分子量 ]:
507.618

[ 闪点 ]:
385.8±32.9 °C

[ 精确质量 ]:
507.262085

[ PSA ]:
112.93000

[ LogP ]:
2.81

[ 蒸汽压 ]:
0.0±2.4 mmHg at 25°C

[ 折射率 ]:
1.602

[ 储存条件 ]:
−20°C

[ 水溶解性 ]:
methylene chloride: 5 mg/mL, clear, colorless

细胞松驰素 CMSDS

详细MSDS(安全技术说明书)

细胞松驰素 C毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: HA5300500

CHEMICAL NAME :: (11)Cytochalasa-5,13,19-triene-1,17-dione, 21-(acetoxy)-7,18-dihydroxy-16,18-dimethyl- 10-phenyl-, (7S,13E,16S,18R,19E,21R)-

CAS REGISTRY NUMBER :: 22144-76-9

LAST UPDATED :: 199203

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CPBTAL Chemical and Pharmaceutical Bulletin. (Japan Pub. Trading Co., USA, 1255 Howard St., San Francisco, CA 94103) V.6- 1958- Volume(issue)/page/year: 21,2268,1973

细胞松驰素 C安全信息

[ 符号 ]:

GHS06, GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H300 + H310 + H330-H361

[ 警示性声明 ]:
P260-P264-P280-P284-P301 + P310-P302 + P350

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
T+: Very toxic;T: Toxic;

[ 风险声明 (欧洲) ]:
26/27/28-63

[ 安全声明 (欧洲) ]:
28-36/37-45

[ 危险品运输编码 ]:
UN 1544 6.1/PG 2

[ WGK德国 ]:
3

[ RTECS号 ]:
HA5300500

[ 包装等级 ]:
I

[ 危险类别 ]:
6.1(a)

细胞松驰素 C文献

Structure of cytochalasins and cytochalasin B binding sites in human erythrocyte membranes.

Biochemistry 19 , 679, (1980)

Twenty cytochalasins were tested for binding to and for inhibition of glucose transport in human erythrocyte membrane. In this membrane three cytochalasin B (CB) binding sites have been identified. Al...

Phenotype modulation in primary cultures of rat aortic smooth muscle cells. Effects of drugs that interfere with the functions of the vacuolar system and the cytoskeleton.

Virchows Arch.,. B, Cell Pathol. 59(1) , 1-10, (1990)

The transition of adult rat aortic smooth muscle cells from a contractile to a synthetic phenotype during the first week of primary culture on a substrate of fibronectin in serum-free medium was studi...

Cytoskeleton regulates expression of genes for transforming growth factor-beta 1 and extracellular matrix proteins in dermal fibroblasts.

J. Cell Physiol. 172(2) , 192-9, (1997)

Cytoskeleton not only controls cell morphology but also regulates cell growth, migration, differentiation, and gene expression, events which are fundamental to embryogenesis, carcinogenesis, and wound...

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