细胞松弛素D

细胞松弛素D用途

Cytochalasin D (Zygosporin A; NSC 209835) 是一种有效、细胞渗透性的肌动蛋白聚合抑制剂,由真菌产生,通过绑定 G-actin 抑制 G-actin–cofilin 的相互作用。Cytochalasin D (Zygosporin A; NSC 209835) 还能抑制 cofilin 与 F-actin 的结合,降低了活细胞中肌动蛋白聚合和解聚的速率。

细胞松弛素D名称

[ CAS 号 ]:
22144-77-0

[ 中文名 ]:
胞松弛素D

[ 英文名 ]:
Lygosporin A

[英文别名 ]:

Methylmalonate
CYTOCHALACIND
Zygosporin A
Lygosporin A
CYTOCHALICIND
MFCD00077706
19-trien-17-one
Cytochalasin D,Zygosporin A
CYTOCHALASIN D
Cytohalasin d

细胞松弛素D生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 细胞骨架 >> Arp2/3复合物

研究领域 >> 其他

[ 靶点 ]

G-actin[1]

[参考文献]

[1]. Shoji K, et al. Cytochalasin D acts as an inhibitor of the actin-cofilin interaction. Biochem Biophys Res Commun. 2012 Jul 20;424(1):52-7.

[2]. Flanagan MD, et al. Cytochalasins block actin filament elongation by binding to high affinity sites associated with F-actin. J Biol Chem. 1980 Feb 10;255(3):835-8.

[3]. May JA, et al. GPIIb-IIIa antagonists cause rapid disaggregation of platelets pre-treated with cytochalasin D. Evidence that the stability of platelet aggregates depends on normal cytoskeletal assembly. Platelets. 1998;9(3-4):227-32.

细胞松弛素D物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
712.1±60.0 °C at 760 mmHg

[ 熔点 ]:
255-260ºC

[ 分子式 ]:
C₃₀H₃₇NO₆

[ 分子量 ]:
507.618

[ 闪点 ]:
384.5±32.9 °C

[ 精确质量 ]:
507.262085

[ PSA ]:
112.93000

[ LogP ]:
2.64

[ 外观性状 ]:
粉末

[ 蒸汽压 ]:
0.0±2.4 mmHg at 25°C

[ 折射率 ]:
1.597

[ 储存条件 ]:
−20°C

[ 水溶解性 ]:
DMSO: soluble

细胞松弛素DMSDS

细胞松弛素D毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GZ4850000

CHEMICAL NAME :: 1H-Cycloundec(d)isoindole-1,11(2H)-dione, 3-benzyl-3,3-alpha,4,5,6,6-alpha,9,10,12,15- decahydro-6,12,15-trihydroxy-4,10,12-trimethyl-5-meth ylene-, 15-acetate

CAS REGISTRY NUMBER :: 22144-77-0

LAST UPDATED :: 199806

DATA ITEMS CITED :: 16

MOLECULAR FORMULA :: C30-H37-N-O6

MOLECULAR WEIGHT :: 507.68

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 900 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 36 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2 mg/kg

TOXIC EFFECTS :: Peripheral Nerve and Sensation - spastic paralysis with or without sensory change Behavioral - excitement

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1850 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 2 gm/kg

SEX/DURATION :: female 7-11 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 1500 ug/kg

SEX/DURATION :: female 8 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetal death Reproductive - Specific Developmental Abnormalities - Central Nervous System

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 1500 ug/kg

SEX/DURATION :: female 8 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - musculoskeletal system

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 2100 ug/kg

SEX/DURATION :: female 7-9 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetal death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 900 ug/kg

SEX/DURATION :: female 7-9 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - Central Nervous System

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 4100 ug/kg

SEX/DURATION :: female 7-11 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - musculoskeletal system

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 4700 ug/kg

SEX/DURATION :: female 7-11 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 1 mg/kg

SEX/DURATION :: female 8 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetal death Reproductive - Specific Developmental Abnormalities - Central Nervous System

MUTATION DATA

TEST SYSTEM :: Rodent - mouse

DOSE/DURATION :: 600 ug/kg

REFERENCE :: JEZOAO Journal of Experimental Zoology. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1904- Volume(issue)/page/year: 250,339,1989

细胞松弛素D安全信息

[ 符号 ]:

GHS06, GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H300-H361

[ 警示性声明 ]:
P264-P281-P301 + P310

[ 个人防护装备 ]:
Eyeshields;Gloves;half-mask respirator (US);multi-purpose combination respirator cartridge (US)

[ 危害码 (欧洲) ]:
T

[ 风险声明 (欧洲) ]:
R25

[ 安全声明 (欧洲) ]:
S45-S36-S37

[ 危险品运输编码 ]:
UN 1544 6.1/PG 2

[ WGK德国 ]:
3

[ RTECS号 ]:
GZ4850000

[ 包装等级 ]:
I

[ 危险类别 ]:
6.1(a)

细胞松弛素D合成路线

细胞松弛素D制备

细胞松弛素D文献

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