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卡比吗唑

卡比吗唑用途

Carbimazole有抗甲亢活性。

卡比吗唑名称

[ CAS 号 ]:
22232-54-8

[ 中文名 ]:
卡比吗唑

[ 英文名 ]:
Carbimazole

[中文别名 ]:

[英文别名 ]:

Carbimazolum
EINECS 244-854-4
Carbimazol
Carbimazole
Neo-Thyreostat
1-Methyl-3-carbethoxy-2-thioglyoxalone
CG 1
Thyrostat
ethyl 3-methyl-2-thionoimidazoline-1-carboxylate
Carbethoxymethimazole

卡比吗唑生物活性

[ 描述 ]:

Carbimazole有抗甲亢活性。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 内分泌

[参考文献]

[1]. Taurog, A., The mechanism of action of the thioureylene antithyroid drugs. Endocrinology, 1976. 98(4): p. 1031-46.

[2]. Magnusson, R.P., A. Taurog, and M.L. Dorris, Mechanism of iodide-dependent catalatic activity of thyroid peroxidase and lactoperoxidase. J Biol Chem, 1984. 259(1): p. 197-205.

[3]. Nakashima, T. and A. Taurog, Rapid conversion of carbimazole to methimazole in serum; evidence for an enzymatic mechanism. Clin Endocrinol (Oxf), 1979. 10(6): p. 637-48.

[相关活性小分子]

卡比吗唑物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
240.4±23.0 °C at 760 mmHg

[ 熔点 ]:
124°C

[ 分子式 ]:
C₇H₁₀N₂O₂S

[ 分子量 ]:
186.232

[ 闪点 ]:
99.2±22.6 °C

[ 精确质量 ]:
186.046295

[ PSA ]:
68.25000

[ LogP ]:
0.34

[ 外观性状 ]:
白色-极淡的黄色晶体-粉末

[ 蒸汽压 ]:
0.0±0.5 mmHg at 25°C

[ 折射率 ]:
1.612

[ 储存条件 ]:
Refrigerator

卡比吗唑MSDS

详细MSDS(安全技术说明书)

卡比吗唑毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NJ2441000

CHEMICAL NAME :: 4-Imidazoline-1-carboxylic acid, 3-methyl-2-thioxo-, ethyl ester

CAS REGISTRY NUMBER :: 22232-54-8

BEILSTEIN REFERENCE NO. :: 0144339

LAST UPDATED :: 199612

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C7-H10-N2-O2-S

MOLECULAR WEIGHT :: 186.25

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - woman

DOSE/DURATION :: 703 mg/kg/17W-I

TOXIC EFFECTS :: Sense Organs and Special Senses (Ear) - change in acuity Sense Organs and Special Senses (Ear) - tinnitus

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - woman

DOSE/DURATION :: 25 mg/kg/6W-I

TOXIC EFFECTS :: Liver - hepatitis (hepatocellular necrosis), diffuse

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - man

DOSE/DURATION :: 23 mg/kg/5W-I

TOXIC EFFECTS :: Liver - jaundice, cholestatic

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Parenteral

SPECIES OBSERVED :: Human - woman

DOSE/DURATION :: 1 mg/kg/1D-I

TOXIC EFFECTS :: Liver - jaundice, other or unclassified

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Yeast - Saccharomyces cerevisiae

DOSE/DURATION :: 1 gm/L

REFERENCE :: CHINAG Chemistry and Industry (London). (Royal Soc. of Chemistry, Distribution Centre, Blackhorse Rd., Letchworth, Herts SG6 1HN, UK) V.1- 1923- Volume(issue)/page/year: (21),847,1980

卡比吗唑安全信息

[ 风险声明 (欧洲) ]:
R22

[ 安全声明 (欧洲) ]:
S22-S36/37/39

[ 危险品运输编码 ]:
3335

[ RTECS号 ]:
NJ2441000

[ 海关编码 ]:
2922499915

卡比吗唑合成路线

详细合成路线

卡比吗唑上下游产品

卡比吗唑上游产品

卡比吗唑下游产品

卡比吗唑制备

由氯代乙醛缩二乙醇经胺化、环合、缩合而得。1.胺化将氯代乙醛缩二乙醇、甲胺、甲醇加入耐压锅中反应得2-甲氨基乙醛缩二乙醇。2.环合将2-甲氨基乙醛缩二乙醇与盐酸、硫氰酸钾一起加热，得1-甲基-2-巯基咪唑。3.缩合将1-甲基-2-巯基咪唑缩于吡啶中，滴加氯甲酸乙酯，得卡比马唑。

卡比吗唑海关

[ 海关编码 ]: 2933290090

[ 中文概述 ]:
2933290090. 其他结构含非稠合咪唑环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933290090. other compounds containing an unfused imidazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

卡比吗唑文献

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The pharmacokinetics of methimazole in a novel lipophilic formulation administered transdermally to healthy cats.

N. Z. Vet. J. 62(4) , 208-13, (2014)

To determine the pharmacokinetics of a novel lipophilic formulation of transdermal methimazole compared to oral carbimazole.Healthy cats received 5 mg carbimazole orally every 12 hours for 13 treatmen...

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