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夫洛丙酮

夫洛丙酮用途

Flopropione 是 5-HT1A 受体拮抗剂,也是儿茶酚-O-甲基转移酶 (COMT) 的抑制剂。

夫洛丙酮名称

[ CAS 号 ]:
2295-58-1

[ 中文名 ]:
夫洛丙酮

[ 英文名 ]:
Flopropione

[中文别名 ]:

[英文别名 ]:

Argobyl
Cospanon
Flopropione
Phloropropiophenone
Gasstenon
EINECS 218-942-8
Ecapron
2',4',6'-Trihydroxypropiophenone
MFCD00016456
Phlopropiophenone

夫洛丙酮生物活性

[ 描述 ]:

Flopropione 是 5-HT1A 受体拮抗剂,也是儿茶酚-O-甲基转移酶 (COMT) 的抑制剂。

[ 相关类别 ]:

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 5-HT受体

信号通路 >> 神经信号通路 >> 5-HT受体

信号通路 >> 代谢酶/蛋白酶 >> COMT

信号通路 >> 神经信号通路 >> COMT

研究领域 >> 神经疾病

[ 靶点 ]

5-HT1A receptor[1], COMT[2]

[参考文献]

[1]. Aso Y et al. Relationship between the crystallization rates of amorphous nifedipine, phenobarbital, and flopropione, and their molecular mobility as measured by their enthalpy relaxation and (1)H NMR relaxation times. J Pharm Sci 89:408-16 (2000).

[2]. Cospanon®. (2007).

[相关活性小分子]

夫洛丙酮物理化学性质

[ 密度 ]:
1.372g/cm3

[ 沸点 ]:
341.7ºC at 760mmHg

[ 熔点 ]:
177°C

[ 分子式 ]:
C₉H₁₀O₄

[ 分子量 ]:
182.17300

[ 闪点 ]:
174.7ºC

[ 精确质量 ]:
182.05800

[ PSA ]:
77.76000

[ LogP ]:
1.39610

[ 外观性状 ]:
固体;White to Orange to Green powder to crystal

[ 蒸汽压 ]:
4E-05mmHg at 25°C

[ 折射率 ]:
1.618

[ 储存条件 ]:
存放于惰性气体之中;避免湿气 (吸湿)

夫洛丙酮MSDS

详细MSDS(安全技术说明书)

夫洛丙酮毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UH4429100

CHEMICAL NAME :: Propiophenone, 2',4',6'-trihydroxy-

CAS REGISTRY NUMBER :: 2295-58-1

BEILSTEIN REFERENCE NO. :: 2096799

LAST UPDATED :: 199701

DATA ITEMS CITED :: 9

MOLECULAR FORMULA :: C9-H10-O4

MOLECULAR WEIGHT :: 182.19

WISWESSER LINE NOTATION :: 2VR BQ DQ FQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2380 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,734,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 412 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,734,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 640 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,734,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 246 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,734,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2780 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,734,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 578 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,734,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 804 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,734,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,734,1982

夫洛丙酮安全信息

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
36/37/38

[ 安全声明 (欧洲) ]:
S26-S36/37/39

[ RTECS号 ]:
UH4429100

[ 海关编码 ]:
2914501900

夫洛丙酮合成路线

详细合成路线

夫洛丙酮海关

[ 海关编码 ]: 2914501900

[ 中文概述 ]:
2914501900 其他酮酚。监管条件:无。增值税率:17.0%。退税率:9.0%。最惠国关税:5.5%。普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 丙酮报明包装

[ Summary ]:
2914501900 other ketone-phenols。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%