长春罗新
长春罗新用途
文乐菌素是一种吲哚生物碱,具有抗肿瘤活性[1]。
长春罗新名称
[ CAS 号 ]:
23360-92-1
[ 中文名 ]:
长春素
[ 英文名 ]:
vinleurosine
[中文别名 ]:
[英文别名 ]:
- (2'β,4'α,5'α)-O',5'-Cyclovincaleukoblastine
- O,5'-Cyclovincaleukoblastine, (2'β,4'α,5'α)-
- (2'β,3'β)-O',3'-Cyclovincaleukoblastine
- (3'R,4'S)-3',4'-Oxy-4'-deoxyvincaleukoblastine
- O,3'-Cyclovincaleukoblastine, (2'β,3'β)-
- vinleurosine
- amotin
- 4'-Deoxy-3',4'-epoxyvincaleucoblastine,9CI
长春罗新生物活性
长春罗新物理化学性质
[ 密度 ]:
1.4±0.1 g/cm3
[ 分子式 ]:
C46H56N4O9
[ 分子量 ]:
808.96
[ 精确质量 ]:
808.404724
[ PSA ]:
146.40000
[ LogP ]:
4.08
[ 折射率 ]:
1.678
长春罗新毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- OH6370000
- CHEMICAL NAME :
- Leurosine
- CAS REGISTRY NUMBER :
- 23360-92-1
- BEILSTEIN REFERENCE NO. :
- 0079636
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 6
- MOLECULAR FORMULA :
- C46-H56-N4-O9
- MOLECULAR WEIGHT :
- 809.06
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 15200 ug/kg
- TOXIC EFFECTS :
- Tumorigenic - active as anti-cancer agent
- REFERENCE :
- PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- Volume(issue)/page/year: 18,667,1984
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 80 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Gastrointestinal - hypermotility, diarrhea Nutritional and Gross Metabolic - weight loss or decreased weight gain
- REFERENCE :
- EKSODD Eksperimental'naya Onkologiya. Experimental Oncology. (V/O Mezhdunarodnaya Kniga, 113095 Mosow, USSR) V.1- 1979- Volume(issue)/page/year: 9(5),76,1987
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 105 mg/kg
- TOXIC EFFECTS :
- Tumorigenic - active as anti-cancer agent
- REFERENCE :
- PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- Volume(issue)/page/year: 18,667,1984
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 12 mg/kg
- TOXIC EFFECTS :
- Gastrointestinal - hypermotility, diarrhea Gastrointestinal - nausea or vomiting
- REFERENCE :
- EKSODD Eksperimental'naya Onkologiya. Experimental Oncology. (V/O Mezhdunarodnaya Kniga, 113095 Mosow, USSR) V.1- 1979- Volume(issue)/page/year: 9(5),76,1987 ** OTHER MULTIPLE DOSE TOXICITY DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 60 mg/kg/30D-I
- TOXIC EFFECTS :
- Blood - changes in bone marrow (not otherwise specified) Blood - changes in leukocyte (WBC) count Related to Chronic Data - death
- REFERENCE :
- EKSODD Eksperimental'naya Onkologiya. Experimental Oncology. (V/O Mezhdunarodnaya Kniga, 113095 Mosow, USSR) V.1- 1979- Volume(issue)/page/year: 9(5),76,1987
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 30 mg/kg/15D-I
- TOXIC EFFECTS :
- Gastrointestinal - nausea or vomiting Blood - changes in leukocyte (WBC) count Related to Chronic Data - death
- REFERENCE :
- EKSODD Eksperimental'naya Onkologiya. Experimental Oncology. (V/O Mezhdunarodnaya Kniga, 113095 Mosow, USSR) V.1- 1979- Volume(issue)/page/year: 9(5),76,1987
长春罗新安全信息
[ 危险品运输编码 ]:
UN 1544
[ 包装等级 ]:
II
[ 危险类别 ]:
6.1(a)
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