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4-(6-氨基-9H-嘌呤-9-基)-4-脱氧-D-赤酮酸

4-(6-氨基-9H-嘌呤-9-基)-4-脱氧-D-赤酮酸用途

Eritadenine (Lentinacin) 是一种 S-腺苷同型半胱氨酸水解酶 (SAHH) 抑制剂,可从香菇的次级代谢产物中获得。Eritadenine 能降低血液胆固醇水平,可用于心血管疾病的研究。

4-(6-氨基-9H-嘌呤-9-基)-4-脱氧-D-赤酮酸名称

[ CAS 号 ]:
23918-98-1

[ 中文名 ]:
4-(9-腺嘌呤)-D-鞘氨醇-2,3-二羟基丁酸

[ 英文名 ]:
Eritadenine

[中文别名 ]:

[英文别名 ]:

Lentysine
d-4-(6-amino-9h-purin-9-yl)-4-deoxyerythronicacid
d-erythronicaci
lentinacin
2(R),3(R)-dihydroxy-4-(9-adenyl)butyric acid
D-eritadenine acid
4-(6-AMinopurin-9-yl)-4-deoxy-D-erythronic Acid
4-(6-amino-purin-9-yl)-2,3-dihydroxy-butyric acid
D-Eritadenine
AA-307

4-(6-氨基-9H-嘌呤-9-基)-4-脱氧-D-赤酮酸生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 心血管疾病

[ 靶点 ]

SAHH[1][2].

[参考文献]

[1]. Yamada T, et al. Structure and function of eritadenine and its 3-deaza analogues: potent inhibitors of S-adenosylhomocysteine hydrolase and hypocholesterolemic agents. Biochem Pharmacol. 2007 Apr 1;73(7):981-9.

[2]. Morales D, et al. Effect of traditional and modern culinary processing, bioaccessibility, biosafety and bioavailability of eritadenine, a hypocholesterolemic compound from edible mushrooms. Food Funct. 2018 Dec 13;9(12):6360-6368.

4-(6-氨基-9H-嘌呤-9-基)-4-脱氧-D-赤酮酸物理化学性质

[ 密度 ]:
1.92g/cm3

[ 沸点 ]:
721.3ºC at 760 mmHg

[ 分子式 ]:
C₉H₁₁N₅O₄

[ 分子量 ]:
253.21

[ 闪点 ]:
390ºC

[ 精确质量 ]:
253.08100

[ PSA ]:
147.38000

[ 蒸汽压 ]:
7.75E-22mmHg at 25°C

[ 折射率 ]:
1.823

[ 储存条件 ]:
2-8°C

4-(6-氨基-9H-嘌呤-9-基)-4-脱氧-D-赤酮酸毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: KF5798000

CHEMICAL NAME :: Erythronic acid, 4-(6-amino-9H-purin-9-yl)-4-deoxy-, D-

CAS REGISTRY NUMBER :: 23918-98-1

LAST UPDATED :: 199509

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C9-H11-N5-O4

MOLECULAR WEIGHT :: 253.25

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TEST SYSTEM :: Insect - Drosophila melanogaster

DOSE/DURATION :: 100 ppm

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 311,305,1994

4-(6-氨基-9H-嘌呤-9-基)-4-脱氧-D-赤酮酸安全信息

[ 海关编码 ]:
2933990090

4-(6-氨基-9H-嘌呤-9-基)-4-脱氧-D-赤酮酸合成路线

详细合成路线

4-(6-氨基-9H-嘌呤-9-基)-4-脱氧-D-赤酮酸上下游产品

4-(6-氨基-9H-嘌呤-9-基)-4-脱氧-D-赤酮酸上游产品

4-(6-氨基-9H-嘌呤-9-基)-4-脱氧-D-赤酮酸下游产品

4-(6-氨基-9H-嘌呤-9-基)-4-脱氧-D-赤酮酸海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%