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单烃基酚

单烃基酚用途

【用途一】
主要用于抗氧剂2246系列、紫外线吸收剂UV-326等的制造
【用途二】
有机合成中间体，用于生产防老剂2246、防老剂2246-S、紫外线吸收剂UV-326。
【用途三】
有机合成。有机合成中间体。

单烃基酚名称

[ CAS 号 ]:
2409-55-4

[ 中文名 ]:
2-叔丁基对甲苯酚

[ 英文名 ]:
2-tert-Butyl-4-methylphenol

[中文别名 ]:

[英文别名 ]:

MONOBUTYL-P-CRESOL
4-Methyl-2,6-tert-butylphenol
2-tert-butyl-p-creso
2-tert-butyl-p-cresol
Phenol, (1,1-dimethylethyl)-4-methyl-
2-Terc.butyl-p-kresol
Phenol, 2- (1,1-dimethylethyl)-4-methyl-
MBPC
2-T-BUTYL-P-CRESOL
o-tert-Butyl-p-cresol

单烃基酚物理化学性质

[ 密度 ]:
1.0±0.1 g/cm3

[ 沸点 ]:
237.0±0.0 °C at 760 mmHg

[ 熔点 ]:
50-52 °C(lit.)

[ 分子式 ]:
C₁₁H₁₆O

[ 分子量 ]:
164.244

[ 闪点 ]:
100.0±0.0 °C

[ 精确质量 ]:
164.120117

[ PSA ]:
20.23000

[ LogP ]:
3.63

[ 外观性状 ]:
白色至黄色-米色结晶块

[ 蒸汽压 ]:
0.0±0.5 mmHg at 25°C

[ 折射率 ]:
1.513

[ 储存条件 ]:
库房低温干燥通风,与氧化剂分开存放

[ 水溶解性 ]:
insoluble

单烃基酚MSDS

单烃基酚毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GO7000000

CHEMICAL NAME :: p-Cresol, 2-tert-butyl-

CAS REGISTRY NUMBER :: 2409-55-4

BEILSTEIN REFERENCE NO. :: 1817645

LAST UPDATED :: 199712

DATA ITEMS CITED :: 19

MOLECULAR FORMULA :: C11-H16-O

MOLECULAR WEIGHT :: 164.27

WISWESSER LINE NOTATION :: QR D1 BX1&1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2500 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Behavioral - ataxia Lungs, Thorax, or Respiration - dyspnea

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 700 mg/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - acute pulmonary edema Gastrointestinal - ulceration or bleeding from small intestine

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 144 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 10 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 940 mg/kg

TOXIC EFFECTS :: Peripheral Nerve and Sensation - spastic paralysis with or without sensory change Behavioral - tremor Behavioral - coma

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 2100 mg/kg

TOXIC EFFECTS :: Peripheral Nerve and Sensation - spastic paralysis with or without sensory change Behavioral - tremor Behavioral - coma

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 2200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 1180 mg/kg

TOXIC EFFECTS :: Behavioral - sleep Behavioral - ataxia Lungs, Thorax, or Respiration - other changes

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 8100 mg/kg/30D-I

TOXIC EFFECTS :: Liver - changes in liver weight Kidney, Ureter, Bladder - urine volume decreased Blood - pigmented or nucleated red blood cells

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 10 mg/m3/15W-I

TOXIC EFFECTS :: Endocrine - other changes Blood - changes in erythrocyte (RBC) count

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - hamster

DOSE/DURATION :: 84 gm/kg/20W-C

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Gastrointestinal - tumors

MUTATION DATA

TEST SYSTEM :: Rodent - rat

DOSE/DURATION :: 336 gm/kg/8W (Continuous)

REFERENCE :: CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980- Volume(issue)/page/year: 11,425,1990 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X2329 No. of Facilities: 736 (estimated) No. of Industries: 7 No. of Occupations: 8 No. of Employees: 12254 (estimated) No. of Female Employees: 786 (estimated)

单烃基酚安全信息

[ 符号 ]:

GHS05, GHS09

[ 信号词 ]:
Danger

[ 危害声明 ]:
H314-H411

[ 警示性声明 ]:
P260-P280-P303 + P361 + P353-P304 + P340 + P310-P305 + P351 + P338

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
C:Corrosive;N:Dangerousfortheenvironment;

[ 风险声明 (欧洲) ]:
R34;R51/53

[ 安全声明 (欧洲) ]:
S26-S36/37/39-S45-S61-S29

[ 危险品运输编码 ]:
UN 2430 8/PG 3

[ WGK德国 ]:
2

[ RTECS号 ]:
GO7000000

[ 包装等级 ]:
III

[ 危险类别 ]:
8

[ 海关编码 ]:
29071900

单烃基酚合成路线

单烃基酚上下游产品

单烃基酚上游产品

单烃基酚下游产品

单烃基酚制备

由对甲苯酚与异丁烯在732#强酸性离子交换树脂催化下作用而得。上述反应在60℃左右进行，反应结束后，滤出催化剂。将滤液加入甲醇烧碱溶液中，使反应副产物2,6-二叔丁基对甲酚析出，过滤，经乙醇重结晶得264抗氧剂作为副产品。将滤去的滤液加硫酸中和、蒸馏、水洗、再经减压蒸馏、结晶、过滤即得成品。

单烃基酚海关

[ 海关编码 ]: 2907199090

[ 中文概述 ]:
2907199090 其他一元酚. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:5.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2907199090 other monophenols VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

单烃基酚文献

Cellular apoptosis and cytotoxicity of phenolic compounds: a quantitative structure-activity relationship study.

J. Med. Chem. 48 , 7234-42, (2005)

In this comprehensive study on the caspase-mediated apoptosis-inducing effect of 51 substituted phenols in a murine leukemia cell line (L1210), we determined the concentrations needed to induce caspas...

Pharmacological actions of thymol and an analogue at GABAB autoreceptors.

Clin. Exp. Pharmacol. Physiol. 41(9) , 623-7, (2014)

GABAB autoreceptors inhibit release of GABA from GABAergic nerve terminals. Agonists of these receptors (e.g. baclofen) inhibit, whereas antagonists (e.g. (+)-(S)-5,5-dimethylmorpholinyl-2-acetic acid...

Role of free radicals in the mode of action of anthralin.

Skin Pharmacol. 1(2) , 115-21, (1988)

Radical reactions of anthralin and its metabolites with skin have been studied by ESR spectroscopy. The influence of compounds which are known to suppress inflammation are described. The ESR spectra r...

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