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叔丁基过氧化氢

叔丁基过氧化氢用途

用作不饱和三聚氰胺树脂涂料的干燥剂、聚合引发剂、有机合成中间体

叔丁基过氧化氢名称

[ CAS 号 ]:
75-91-2

[ 中文名 ]:
叔丁基过氧化氢

[ 英文名 ]:
tert-Butyl Hydroperoxide

[中文别名 ]:

[英文别名 ]:

2-hydroperoxy-2-methylpropane
MFCD00002130
EINECS 200-915-7
tert-Butyl hydroperoxide

叔丁基过氧化氢物理化学性质

[ 密度 ]:
0.9±0.1 g/cm3

[ 沸点 ]:
120.4±9.0 °C at 760 mmHg

[ 熔点 ]:
-2.8 °C

[ 分子式 ]:
C₄H₁₀O₂

[ 分子量 ]:
90.121

[ 闪点 ]:
35.0±0.0 °C

[ 精确质量 ]:
90.068077

[ PSA ]:
29.46000

[ LogP ]:
1.38

[ 外观性状 ]:
透明液体

[ 蒸汽压 ]:
7.4±0.5 mmHg at 25°C

[ 折射率 ]:
1.399

[ 储存条件 ]:
库房通风低温,轻装轻卸,与有机物、还原剂、硫、磷易燃物分开存放

[ 稳定性 ]:
Stable, but may explode if heated under confinement. Decomposition may be accelerated by traces of metals, molecular sieve or other contaminants. Incompatible with reducing agents, combustible material, acids.

[ 水溶解性 ]:
Miscible

叔丁基过氧化氢MSDS

详细MSDS(安全技术说明书)

叔丁基过氧化氢毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: EQ4900000

CHEMICAL NAME :: tert-Butylhydroperoxide

CAS REGISTRY NUMBER :: 75-91-2

BEILSTEIN REFERENCE NO. :: 1098280

LAST UPDATED :: 199806

DATA ITEMS CITED :: 38

MOLECULAR FORMULA :: C4-H10-O2

MOLECULAR WEIGHT :: 90.14

WISWESSER LINE NOTATION :: QOX1&1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: Rinsed with water

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 370 mg/kg

TOXIC EFFECTS :: Behavioral - irritability Gastrointestinal - alteration in gastric secretion Blood - hemorrhage

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 500 ppm/4H

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - dyspnea

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 790 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 87 mg/kg

TOXIC EFFECTS :: Behavioral - muscle weakness Behavioral - ataxia

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 320 mg/kg

TOXIC EFFECTS :: Behavioral - irritability Gastrointestinal - alteration in gastric secretion Blood - hemorrhage

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 350 ppm/4H

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - dyspnea

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 246 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 460 uL/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - cyanosis Liver - other changes Kidney, Ureter, Bladder - other changes in urine composition

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 107 mg/m3/17W-I

TOXIC EFFECTS :: Sense Organs and Special Senses (Olfaction) - change in sensation of smell Kidney, Ureter, Bladder - other changes in urine composition Nutritional and Gross Metabolic - changes in chlorine

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 365 mg/kg/7W-I

TOXIC EFFECTS :: Related to Chronic Data - death

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 107 mg/m3/17W-I

TOXIC EFFECTS :: Blood - changes in erythrocyte (RBC) count Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: Sex chromosome loss and nondisjunction

TYPE OF TEST :: Sex chromosome loss and nondisjunction

TYPE OF TEST :: Cytogenetic analysis

TYPE OF TEST :: Cytogenetic analysis

TYPE OF TEST :: Dominant lethal test

MUTATION DATA

TYPE OF TEST :: Sex chromosome loss and nondisjunction

TEST SYSTEM :: Rodent - hamster Lung

DOSE/DURATION :: 34 umol/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 182,135,1987 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-GERMANY JAN 1993 OEL-RUSSIA:STEL 5 mg/m3;Skin JAN 1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 14730 No. of Facilities: 75 (estimated) No. of Industries: 2 No. of Occupations: 3 No. of Employees: 433 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 14730 No. of Facilities: 266 (estimated) No. of Industries: 8 No. of Occupations: 14 No. of Employees: 12168 (estimated) No. of Female Employees: 4787 (estimated)

叔丁基过氧化氢安全信息

[ 符号 ]:

GHS02, GHS05, GHS06, GHS08, GHS09

[ 信号词 ]:
Danger

[ 危害声明 ]:
H226-H242-H302-H304-H311 + H331-H314-H317-H336-H341-H410

[ 警示性声明 ]:
P210-P234-P280-P301 + P310-P303 + P361 + P353-P304 + P340 + P310-P305 + P351 + P338-P331-P403 + P233

[ 个人防护装备 ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
C:Corrosive

[ 风险声明 (欧洲) ]:
R10;R20/21/22;R34;R43;R52/53;R7

[ 安全声明 (欧洲) ]:
S14-S3/7-S61-S45-S36/37/39-S24-S17-S16-S14A-S26-S62

[ 危险品运输编码 ]:
UN 3109 5.2

[ WGK德国 ]:
3

[ RTECS号 ]:
EQ4900000

[ 包装等级 ]:
II

[ 危险类别 ]:
5.2

叔丁基过氧化氢合成路线

详细合成路线

叔丁基过氧化氢上下游产品

叔丁基过氧化氢上游产品

叔丁基过氧化氢下游产品

叔丁基过氧化氢制备

1.叔丁醇与硫酸反应生成硫酸氢叔丁酯，再与过氧化氢反应而得。将叔丁醇加入反应锅，搅拌下于35℃加入过氧化氢，然后升温至50℃，滴加70%硫酸，加完后反应5h，温度保持在55-60℃，静置分层，取上部油层用无水硫酸钠干燥，过滤，得叔丁基过氧化氢。

2.制法：

于装有搅拌器、温度计、滴液漏斗的反应瓶中，加入叔丁醇（2）74g（1.0mol），冰浴冷却，加入140g70%的硫酸（1.0mol），于5℃反应生成硫酸单叔丁酯。而后0～5℃滴加27%的过氧化氢126g（1.0mol），约30min加完。加完后室温放置过夜。分出有机层，用碳酸镁和10mL水组成的悬浊液中和，20mL水洗涤，无水硫酸镁干燥，得产品70.5g，其中含66%的叔丁基氢过氧化物（1），34%的过氧化二叔丁基，活性氧含量11.74%。用填充柱进行减压分馏，收集12～13℃/2.66kPa的馏分为过氧化二叔丁基，4.5～5℃/266Pa的馏分为化合物（1），绝对不要常压蒸馏。

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