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苯甲醇

苯甲醇用途

苯甲醇 (Benzyl alcohol) 是一种芳香醇,是一种无色液体,带有温和的芳香气味。

苯甲醇名称

[ CAS 号 ]:
100-51-6

[ 中文名 ]:
苯甲醇

[ 英文名 ]:
Benzyl alcohol

[中文别名 ]:

苄醇

[英文别名 ]:

EINECS 202-859-9
Benzyl alcohol
MFCD00004599

苯甲醇生物活性

[ 描述 ]:

苯甲醇 (Benzyl alcohol) 是一种芳香醇,是一种无色液体,带有温和的芳香气味。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 其他

[相关活性小分子]

苯甲醇物理化学性质

[ 密度 ]:
1.0±0.1 g/cm3

[ 沸点 ]:
204.7±0.0 °C at 760 mmHg

[ 熔点 ]:
-15 °C

[ 分子式 ]:
C₇H₈O

[ 分子量 ]:
108.138

[ 闪点 ]:
93.9±0.0 °C

[ 精确质量 ]:
108.057518

[ PSA ]:
20.23000

[ LogP ]:
1.03

[ 外观性状 ]:
无色液体

[ 蒸汽密度 ]:
3.7 (vs air)

[ 蒸汽压 ]:
0.2±0.4 mmHg at 25°C

[ 折射率 ]:
1.546

[ 储存条件 ]:
库房通风低温干燥

[ 水溶解性 ]:
4.29 g/100 mL (20 ºC)

苯甲醇MSDS

详细MSDS(安全技术说明书)

苯甲醇毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DN3150000

CHEMICAL NAME :: Benzyl alcohol

CAS REGISTRY NUMBER :: 100-51-6

BEILSTEIN REFERENCE NO. :: 0878307

LAST UPDATED :: 199806

DATA ITEMS CITED :: 38

MOLECULAR FORMULA :: C7-H8-O

MOLECULAR WEIGHT :: 108.15

WISWESSER LINE NOTATION :: Q1R

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Human - man

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Mammal - pig

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1230 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - excitement Behavioral - coma

TYPE OF TEST :: LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1000 ppm/8H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 400 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1700 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - miosis (pupillary constriction) Behavioral - coma Kidney, Ureter, Bladder - other changes

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 53 mg/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - dyspnea

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraarterial

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 441 mg/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - chronic pulmonary edema Lungs, Thorax, or Respiration - dyspnea

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1360 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 650 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - dyspnea

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 324 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 50 mg/kg

TOXIC EFFECTS :: Behavioral - ataxia Lungs, Thorax, or Respiration - dyspnea Gastrointestinal - hypermotility, diarrhea

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Parenteral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 9 mg/kg

TOXIC EFFECTS :: Behavioral - tremor Lungs, Thorax, or Respiration - other changes

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 10 gm/kg

TOXIC EFFECTS :: Behavioral - tremor Behavioral - muscle weakness Gastrointestinal - changes in structure or function of salivary glands

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 625 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 1040 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity)

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 2500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - wild bird species

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2100 mg/kg/21D-I

TOXIC EFFECTS :: Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 13 gm/kg/13W-I

TOXIC EFFECTS :: Brain and Coverings - other degenerative changes Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 24 mL/kg/12D-I

TOXIC EFFECTS :: Liver - other changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - dehydrogenases

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 12 gm/kg/16D-I

TOXIC EFFECTS :: Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 6 gm/kg

SEX/DURATION :: female 6-13 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)

MUTATION DATA

TYPE OF TEST :: Cytogenetic analysis

TEST SYSTEM :: Rodent - hamster Ovary

DOSE/DURATION :: 4 ug/L

REFERENCE :: NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-343,1989 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-RUSSIA:STEL 5 mg/m3;Skin JAN 1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 11360 No. of Facilities: 7284 (estimated) No. of Industries: 85 No. of Occupations: 68 No. of Employees: 138757 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 11360 No. of Facilities: 19005 (estimated) No. of Industries: 128 No. of Occupations: 127 No. of Employees: 404916 (estimated) No. of Female Employees: 236470 (estimated)

苯甲醇安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302 + H332-H319

[ 警示性声明 ]:
P261-P301 + P312 + P330-P304 + P340 + P312-P305 + P351 + P338

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
T:Toxic

[ 风险声明 (欧洲) ]:
20/22;63;43;36/37/38;23/24/25;45;40

[ 安全声明 (欧洲) ]:
S26-S36/37-S24/25-S23-S53

[ 危险品运输编码 ]:
UN 1593 6.1/PG 3

[ WGK德国 ]:
1

[ RTECS号 ]:
DN3150000

[ 海关编码 ]:
2906210000

苯甲醇合成路线

详细合成路线

苯甲醇上下游产品

苯甲醇上游产品

苯甲醇下游产品

苯甲醇制备

1.苯甲醇天然存在于橙花、依兰、茉莉、栀子、金合欢、丁香花、风信子中，工业上以氯苄或苯甲醛为原料制备。
在12%的纯碱溶液中加入氯苄，加热至93℃搅拌反应5h，然后升温至101～103℃继续反应10h。反应结束后冷却至室温，加入食盐至饱和，静置分层，取上层液经常压蒸馏得粗品，再精制得成品。收率70%～72%。

在氢氧化钠存在下甲醛与苯甲醛，经歧化反应制备苯甲醇。

2.以氯化苄为原料，在碱的催化作用下加热水解而得。 3. 将氯化苄、碳酸钠和水以一定配比混合，快速搅拌，使油层乳化，边搅拌边将温度升至90℃，当生成的二氧化碳气体不再逸出时，继续升温至101～103℃，使水解反应完全：反应结束后冷却，静置分层。取油层用水洗涤数次，并入水层，然后常压蒸馏，先蒸出水、氯化苄等低沸物，作为初馏分，再收集203～206℃作为主馏分，即为成品。 4. 烟草：BU，56；OR，57；BU，13；FC，9， 18；BU，OR，18；FC，BU，OR，40。 5.制法：于装有搅拌器、回流冷凝器、温度计的反应瓶中，加入水250mL，碳酸钠56g，氯化苄(2)63.3g(0.5mol),剧烈搅拌以使氯化苄乳化。加入至微沸(约95℃)。反应中有二氧化碳生成。二氧化碳气泡停止逸出时说明反应结束，而后再搅拌反应0.5h。冷却，分出有机层，水洗，得粗品苄基醇。分馏，收集204～205℃的馏分，得苄基醇 ^①(1)40g,收率74%。

苯甲醇海关

[ 海关编码 ]: 2906210000

[ 中文概述 ]:
2906210000 苄醇。监管条件:无。增值税率:17.0%。退税率:9.0%。最低关税:5.0%。普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2906210000 phenylmethanol。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。Lowest tariff:5.0%。General tariff:30.0%

苯甲醇文献

Acetonitrile adduct formation as a sensitive means for simple alcohol detection by LC-MS.

J. Am. Soc. Mass Spectrom. 25(11) , 1987-90, (2014)

Simple alcohols formed protonated acetonitrile adducts containing up to two acetonitrile molecules when analyzed by ESI or APCI in the presence of acetonitrile in the solvent. These acetonitrile adduc...

Olfactometry Profiles and Quantitation of Volatile Sulfur Compounds of Swiss Tilsit Cheeses.

J. Agric. Food Chem. 63 , 7511-21, (2015)

To establish the odor profiles of three differently fabricated commercial Swiss Tilsit cheeses, analyses were conducted using headspace solid-phase microextraction gas chromatography-mass spectrometry...

Real-time monitoring of H2O2 release from single cells using nanoporous gold microelectrodes decorated with platinum nanoparticles.

Analyst 140 , 3753-8, (2015)

Here, we report a self-supported nanoporous gold microelectrode decorated with well-dispersed and tiny platinum nanoparticles as an electrochemical nonenzymatic hydrogen peroxide biosensor. Nanoporous...

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苯甲醇