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苯甲酰胺

苯甲酰胺用途

苯甲酰胺抑制聚腺苷二磷酸核糖聚合酶(PARP)。

苯甲酰胺名称

[ CAS 号 ]:
55-21-0

[ 中文名 ]:
苯甲酰胺

[ 英文名 ]:
Benzamide

[中文别名 ]:

苯酰胺

[英文别名 ]:

PHENYLFORMAMIDE
phenylamide
benzoic acid amide
Benzamid
BENZOIC AMIDE
Benzamide
EINECS 200-227-7
Phenyl formamide
benzene amide
benzene carboxamide

苯甲酰胺生物活性

[ 描述 ]:

苯甲酰胺抑制聚腺苷二磷酸核糖聚合酶(PARP)。

[ 相关类别 ]:

信号通路 >> 表观遗传学 >> PARP

信号通路 >> 细胞周期/DNA损伤 >> PARP

[ 靶点 ]

Human Endogenous Metabolite

苯甲酰胺物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
221.5±23.0 °C at 760 mmHg

[ 熔点 ]:
125-128 °C(lit.)

[ 分子式 ]:
C₇H₇NO

[ 分子量 ]:
121.137

[ 闪点 ]:
87.8±22.6 °C

[ 精确质量 ]:
121.052765

[ PSA ]:
43.09000

[ LogP ]:
0.84

[ 外观性状 ]:
白色晶体粉末

[ 蒸汽压 ]:
0.1±0.5 mmHg at 25°C

[ 折射率 ]:
1.547

[ 储存条件 ]:
通风低温干燥

[ 稳定性 ]:
Stable. Combustible. Incompatible with strong oxidizing agents.

[ 水溶解性 ]:
1.35 g/100 mL (20 ºC)

苯甲酰胺MSDS

苯甲酰胺毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CU8700000

CHEMICAL NAME :: Benzamide

CAS REGISTRY NUMBER :: 55-21-0

BEILSTEIN REFERENCE NO. :: 0385876

LAST UPDATED :: 199709

DATA ITEMS CITED :: 13

MOLECULAR FORMULA :: C7-H7-N-O

MOLECULAR WEIGHT :: 121.15

WISWESSER LINE NOTATION :: ZVR

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 781 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - ptosis Behavioral - muscle weakness Lungs, Thorax, or Respiration - acute pulmonary edema

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1160 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1282 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - ptosis Behavioral - muscle weakness Lungs, Thorax, or Respiration - acute pulmonary edema

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: Micronucleus test

MUTATION DATA

TYPE OF TEST :: Cytogenetic analysis

TEST SYSTEM :: Mammal - species unspecified Kidney

DOSE/DURATION :: 1000 ppm

REFERENCE :: IJEBA6 Indian Journal of Experimental Biology. (Publications & Information Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963- Volume(issue)/page/year: 18,329,1980

苯甲酰胺安全信息

[ 符号 ]:

GHS07, GHS08

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H341

[ 警示性声明 ]:
P281

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn:Harmful

[ 风险声明 (欧洲) ]:
R22

[ 安全声明 (欧洲) ]:
S22-S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
1

[ RTECS号 ]:
CU8700000

[ 海关编码 ]:
29242995

苯甲酰胺合成路线

苯甲酰胺上下游产品

苯甲酰胺上游产品

苯甲酰胺下游产品

苯甲酰胺制备

由苯甲酰氯与氨反应而得。先在搪玻璃反应锅内加入碳酸铵和相对密度0.905以下的氨水，搅拌，在40℃以下滴加苯甲酰氯。加完后再搅拌30min，至无苯甲酰氯气味为止。将粗品过滤、水洗、蒸馏水重结晶即得成品。

苯甲酰胺海关

[ 海关编码 ]: 2924299090

[ 中文概述 ]:
2924299090. 其他环酰胺（包括环氨基甲酸酯）（包括其衍生物以及他们的盐）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 包装

[ Summary ]:
2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

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