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4,6-二羟基吡唑啉[3,4-d]嘧啶

4,6-二羟基吡唑啉[3,4-d]嘧啶用途

Oxopurinol (Oxipurinol) 是 Allopurinol 的主要活性代谢产物,是一种黄嘌呤氧化酶 (xanthine oxidase) 抑制剂。Oxipurinol 可用于调节血尿酸水平,治疗痛风。

4,6-二羟基吡唑啉[3,4-d]嘧啶名称

[ CAS 号 ]:
2465-59-0

[ 中文名 ]:
羟基嘌呤

[ 英文名 ]:
Oxipurinol

[中文别名 ]:

[英文别名 ]:

OXYPURINOL
BW-55-5
Alloxanthine
OXIPURINOL
1H-pyrazolo[3,4-d]pyrimidine-4,6-diol
4,6-Dihydropyrazolo Pyrimidine
MFCD00056934
1,7-Dihydro
4,6-DIHYDROXYPYRAZOLO[3,4-D]PYRIMIDINE
4,6-Dihydroxy-1H-pyrazolo[3,4-d]pyrimidine

4,6-二羟基吡唑啉[3,4-d]嘧啶生物活性

[ 描述 ]:

Oxopurinol (Oxipurinol) 是 Allopurinol 的主要活性代谢产物,是一种黄嘌呤氧化酶 (xanthine oxidase) 抑制剂。Oxipurinol 可用于调节血尿酸水平,治疗痛风。

[ 相关类别 ]:

研究领域 >> 炎症/免疫

研究领域 >> 代谢疾病

信号通路 >> 代谢酶/蛋白酶 >> 黄嘌呤氧化酶

[ 靶点 ]

Human Endogenous Metabolite

[体外研究]

别嘌呤醇迅速代谢(半衰期约1小时)至其活性代谢物羟基嘌呤醇。 Oxypurinol是黄嘌呤氧化还原酶的抑制剂,具有相当长的消除半衰期(约23小时)[1]。

[参考文献]

[1]. Stocker SL, et al. The pharmacokinetics of oxypurinol in people with gout. Br J Clin Pharmacol. 2012 Sep;74(3):477-89.

4,6-二羟基吡唑啉[3,4-d]嘧啶物理化学性质

[ 密度 ]:
2.19g/cm3

[ 沸点 ]:
662.9ºC at 760 mmHg

[ 熔点 ]:
300 °C

[ 分子式 ]:
C₅H₄N₄O₂

[ 分子量 ]:
152.11

[ 闪点 ]:
354.7ºC

[ 精确质量 ]:
152.03300

[ PSA ]:
94.92000

[ 蒸汽压 ]:
3.5E-18mmHg at 25°C

[ 折射率 ]:
1.989

[ 储存条件 ]:
-20°C Freezer

4,6-二羟基吡唑啉[3,4-d]嘧啶MSDS

详细MSDS(安全技术说明书)

4,6-二羟基吡唑啉[3,4-d]嘧啶安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi: Irritant;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ 海关编码 ]:
2933990090

4,6-二羟基吡唑啉[3,4-d]嘧啶上下游产品

4,6-二羟基吡唑啉[3,4-d]嘧啶上游产品

4,6-二羟基吡唑啉[3,4-d]嘧啶下游产品

4,6-二羟基吡唑啉[3,4-d]嘧啶海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

4,6-二羟基吡唑啉[3,4-d]嘧啶文献

Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.

Chem. Res. Toxicol. 23 , 171-83, (2010)

Drug-induced liver injury is one of the main causes of drug attrition. The ability to predict the liver effects of drug candidates from their chemical structures is critical to help guide experimental...

Evaluation of neuronal protective effects of xanthine oxidoreductase inhibitors on severe whole-brain ischemia in mouse model and analysis of xanthine oxidoreductase activity in the mouse brain.

Neurol. Med. Chir. (Tokyo) 55(1) , 77-85, (2015)

Global cerebral ischemia and reperfusion (I/R) often result in high mortality. Free radicals play an important role in global cerebral I/R. Xanthine oxidoreductase (XOR) inhibitors, such as allopurino...

Systematic and Molecular Basis of the Antibacterial Action of Quinoxaline 1,4-Di-N-Oxides against Escherichia coli.

PLoS ONE 10 , e0136450, (2015)

Quinoxaline 1,4-di-N-oxides (QdNOs) are widely known as potent antibacterial agents, but their antibacterial mechanisms are incompletely understood. In this study, the transcriptomic and proteomic pro...

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