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SB 328437,CCR3拮抗剂

SB 328437,CCR3拮抗剂用途

SB-328437是一种有效、选择性的非肽CCR3拮抗剂,IC50为4.5 nM[1]。

SB 328437,CCR3拮抗剂名称

[ CAS 号 ]:
247580-43-4

[ 中文名 ]:
SB 328437,CCR3拮抗剂

[ 英文名 ]:
SB 328437

[英文别名 ]:

SB 328437,CCR3拮抗剂生物活性

[ 描述 ]:

SB-328437是一种有效、选择性的非肽CCR3拮抗剂,IC50为4.5 nM[1]。

[ 相关类别 ]:

信号通路 >> G 蛋白偶联受体/G 蛋白 >> CCR

信号通路 >> 免疫及炎症 >> CCR

研究领域 >> 炎症/免疫

[ 靶点 ]

CCR3:4.5 nM (IC50)

[参考文献]

[1]. White JR, et al. Identification of potent, selective non-peptide CC chemokine receptor-3 antagonist that inhibits eotaxin-, eotaxin-2-, and monocyte chemotactic protein-4-induced eosinophil migration. J Biol Chem. 2000 Nov 24;275(47):36626-31.

SB 328437,CCR3拮抗剂物理化学性质

[ 分子式 ]:
C₂₁H₁₈N₂O₅

[ 分子量 ]:
378.37800

[ 精确质量 ]:
378.12200

[ PSA ]:
104.71000

[ LogP ]:
4.36010

[ 储存条件 ]:
-20°C，干燥

SB 328437,CCR3拮抗剂MSDS

详细MSDS(安全技术说明书)

SB 328437,CCR3拮抗剂安全信息

[ 符号 ]:

GHS07, GHS09

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H400

[ 警示性声明 ]:
P273

[ 危险品运输编码 ]:
UN 3077 9 / PGIII

SB 328437,CCR3拮抗剂文献

CCR3 antagonists: a survey of the patent literature.

Expert Opin. Ther. Pat. 19(8) , 1109-32, (2009)

Since the mid-1990s, there has been significant effort invested in the discovery and clinical development of CC chemokine receptor-3 (CCR3) antagonists as potential therapeutics for airway disease.A p...

Selective suppression of Th2-mediated airway eosinophil infiltration by low-molecular weight CCR3 antagonists.

Int. Immunol. 19(8) , 913-21, (2007)

The effects of selective CC chemokine receptor (CCR)-3 antagonists on antigen-induced leukocyte accumulation in the lungs of mice adoptively transferred with in vitro-differentiated T(h)1 and T(h)2 we...

CCR3 and choroidal neovascularization.

PLoS ONE 6 , e17106, (2011)

Age-related macular degeneration (AMD) is the leading cause of irreversible blindness in the elderly in industrialized countries. The "wet" AMD, characterized by the development of choroidal neovacula...

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