Pyrimidine,2,4-bis(1-aziridinyl)-6-chloro-

用途

Ethimidine (Aethimidinum) 可以降低先前移植肉瘤或癌细胞的大鼠血清中的游离 SH (巯基)。

名称

[ CAS 号 ]:
2482-80-6

[ 英文名 ]:
Pyrimidine,2,4-bis(1-aziridinyl)-6-chloro-

[英文别名 ]:

2,4-Bis-aziridin-1-yl-6-chlor-pyrimidin
Ethymidine
Aethimidinum
2,4-Diethylenimino-6-chloropyrimidine
2,4-bis-aziridin-1-yl-6-chloro-pyrimidine
Etimidin
Ethimidine
2,6-Diethylenimino-4-chloropyrimidine
Aethimidinium

生物活性

[ 描述 ]:

Ethimidine (Aethimidinum) 可以降低先前移植肉瘤或癌细胞的大鼠血清中的游离 SH (巯基)。

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> 其他 >> 其他

[参考文献]

[1]. G I Kulik, et al. Effect of alkylating antitumour preparations on the blood serum SH-groups under clinical and experimental conditions. Vrach Delo. 1966 Sep:9:87-9.

物理化学性质

[ 密度 ]:
1.561g/cm3

[ 沸点 ]:
410.4ºC at 760mmHg

[ 分子式 ]:
C₈H₉ClN₄

[ 分子量 ]:
196.63700

[ 闪点 ]:
202ºC

[ 精确质量 ]:
196.05200

[ PSA ]:
31.80000

[ LogP ]:
0.90000

[ 蒸汽压 ]:
6.06E-07mmHg at 25°C

[ 折射率 ]:
1.711

毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UV7065000

CHEMICAL NAME :: Pyrimidine, 2,4-bis(1-aziridinyl)-6-chloro-

CAS REGISTRY NUMBER :: 2482-80-6

BEILSTEIN REFERENCE NO. :: 0188373

LAST UPDATED :: 199612

DATA ITEMS CITED :: 8

MOLECULAR FORMULA :: C8-H9-Cl-N4

MOLECULAR WEIGHT :: 196.66

WISWESSER LINE NOTATION :: T6N CNJ DG B- AT3NTJ& F- AT3NTJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 15 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Ear) - change in acuity Gastrointestinal - nausea or vomiting Tumorigenic - active as anti-cancer agent

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 15 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Ear) - change in acuity Gastrointestinal - nausea or vomiting Tumorigenic - active as anti-cancer agent

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Parenteral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 15 mg/kg

TOXIC EFFECTS :: Behavioral - changes in motor activity (specific assay) Behavioral - muscle contraction or spasticity Lungs, Thorax, or Respiration - dyspnea

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Parenteral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 1350 ug/kg

TOXIC EFFECTS :: Behavioral - changes in motor activity (specific assay) Behavioral - muscle contraction or spasticity Lungs, Thorax, or Respiration - dyspnea

TYPE OF TEST :: Mutation test systems - not otherwise specified

MUTATION DATA

TEST SYSTEM :: Rodent - rat

DOSE/DURATION :: 2500 ug/kg

REFERENCE :: BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM. Volume(issue)/page/year: 6,357,1951

安全信息

[ 海关编码 ]:
2933990090

海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%