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庆大霉素C1a

庆大霉素C1a用途

庆大霉素C1a是半合成抗生素阿替米辛的前体,具有抗菌活性。庆大霉素C1a是庆大霉素复合物的主要成分[1][2]。

庆大霉素C1a名称

[ CAS 号 ]:
26098-04-4

[ 中文名 ]:
庆大霉素C1a

[ 英文名 ]:
gentamycin C1a

[英文别名 ]:

Geneticin C1a
Gentamicin C1a Pentaacetate Salt
GentaMycin C1a Acetate
Gentamycin C1a
GentaMicin C3 Acetate
Gentamisin C3
Gentamicin D
Gentamicin C1a
GentaMicin D Acetate
Gentamicin C3

庆大霉素C1a生物活性

[ 描述 ]:

庆大霉素C1a是半合成抗生素阿替米辛的前体,具有抗菌活性。庆大霉素C1a是庆大霉素复合物的主要成分[1][2]。

[ 相关类别 ]:

研究领域 >> 感染

信号通路 >> 抗感染 >> 细菌

[体外研究]

庆大霉素C1a抑制大肠杆菌,P。绿脓杆菌和金黄色葡萄球菌活性,国际50值为 1 mg/mL[2]庆大霉素C1a(2mM,48小时)对 OC-k3型细胞活力没有影响[2].

[体内研究]

庆大霉素C1a(4mg/kg静脉推注剂量,单次) 在比格犬体内的平均停留时间为 84分钟,氯值为 1.81 mL/min/kg[3]

[参考文献]

[1]. Li D, et al. Construction of a gentamicin C1a-overproducing strain of Micromonospora purpurea by inactivation of the gacD gene. Microbiol Res. 2013 Jun 12;168(5):263-7.

[2]. Ishikawa M, et al. Lower ototoxicity and absence of hidden hearing loss point to gentamicin C1a and apramycin as promising antibiotics for clinical use. Sci Rep. 2019 Feb 20;9(1):2410.

[3]. Isoherranen N, et al. Pharmacokinetics of gentamicin C(1), C(1a), and C(2) in beagles after a single intravenous dose. Antimicrob Agents Chemother. 2000 Jun;44(6):1443-7.

庆大霉素C1a物理化学性质

[ 密度 ]:
1.36g/cm3

[ 沸点 ]:
675.2ºC at 760 mmHg

[ 熔点 ]:
102-108ºC

[ 分子式 ]:
C₁₉H₃₉N₅O₇

[ 分子量 ]:
449.54200

[ 闪点 ]:
362.1ºC

[ 精确质量 ]:
449.28500

[ PSA ]:
213.72000

[ 蒸汽压 ]:
3.97E-21mmHg at 25°C

[ 折射率 ]:
1.603

[ 储存条件 ]:
-20°C，干燥

庆大霉素C1a毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: WK2290000

CHEMICAL NAME :: D-Streptamine, O-3-deoxy-4-C-methyl-3-(methylamino)-beta-L-arabinopy ranosyl-(1-6)-O-(2,6- diamino-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyrano syl-(1-4))-2-deoxy-

CAS REGISTRY NUMBER :: 26098-04-4

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C19-H39-N5-O7

MOLECULAR WEIGHT :: 449.63

WISWESSER LINE NOTATION :: T6OTJ CQ DM1 EQ E1 BO- BL6TJ AZ CQ EZ DO- BT6OTJ CZ F1Z

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 70 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 38KLAC "Structure-Activity Relationship among the Semisynthetic Antibiotics," Perlman, D., ed., New York, Academic Press, 1977 Volume(issue)/page/year: -,239,1977

庆大霉素C1a安全信息

[ 危害码 (欧洲) ]:
Xn

[ 海关编码 ]:
3004909090

庆大霉素C1a合成路线

详细合成路线

庆大霉素C1a上下游产品

庆大霉素C1a上游产品

庆大霉素C1a下游产品

庆大霉素C1a海关

[ 海关编码 ]: 3004909090