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4α-佛波醇-12,13-二癸酸酯

4α-佛波醇-12,13-二癸酸酯用途

4α-佛波醇12,13-二癸酸酯(4αPDD)是一种具有抗自身免疫原性作用的TRPV4激动剂。4α-佛波醇12,13-癸二酸促进钙内流[1]。

4α-佛波醇-12,13-二癸酸酯名称

[ CAS 号 ]:
27536-56-7

[ 中文名 ]:
4α-佛波醇-12,13-二癸酸酯

[ 英文名 ]:
4alpha-PDD

[英文别名 ]:

4a-phorbol 12,13-didecanoate
Phorbol-9,9a-didecanoat
4a-phenyl-4,4a,5,6,7,8-hexahydro-2H-cinnolin-3-one

4α-佛波醇-12,13-二癸酸酯生物活性

[ 描述 ]:

4α-佛波醇12,13-二癸酸酯(4αPDD)是一种具有抗自身免疫原性作用的TRPV4激动剂。4α-佛波醇12,13-癸二酸促进钙内流[1]。

[ 相关类别 ]:

信号通路 >> 跨膜转运 >> TRP频道

研究领域 >> 炎症/免疫

研究领域 >> 神经疾病

[参考文献]

[1]. Hiromi Tsushima, et al. Antidipsogenic effects of a TRPV4 agonist, 4alpha-phorbol 12,13-didecanoate, injected into the cerebroventricle. Am J Physiol Regul Integr Comp Physiol. 2006 Jun;290(6):R1736-41.

[2]. Lori Birder, et al. Activation of urothelial transient receptor potential vanilloid 4 by 4alpha-phorbol 12,13-didecanoate contributes to altered bladder reflexes in the rat. J Pharmacol Exp Ther. 2007 Oct;323(1):227-35.

4α-佛波醇-12,13-二癸酸酯物理化学性质

[ 密度 ]:
1.14g/cm3

[ 沸点 ]:
734.2ºC at 760mmHg

[ 分子式 ]:
C₄₀H₆₄O₈

[ 分子量 ]:
672.93100

[ 闪点 ]:
212.4ºC

[ 精确质量 ]:
672.46000

[ PSA ]:
130.36000

[ LogP ]:
7.31330

[ 蒸汽压 ]:
6.92E-25mmHg at 25°C

[ 折射率 ]:
1.546

[ 储存条件 ]:
-20°C

4α-佛波醇-12,13-二癸酸酯MSDS

详细MSDS(安全技术说明书)

4α-佛波醇-12,13-二癸酸酯安全信息

[ 符号 ]:

GHS06, GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H300 + H310 + H330-H334-H351

[ 警示性声明 ]:
P260-P264-P280-P284-P301 + P310-P302 + P350

[ 个人防护装备 ]:
Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
T+: Very toxic;

[ 风险声明 (欧洲) ]:
26/27/28-40-43

[ 安全声明 (欧洲) ]:
36/37/39-45

[ 危险品运输编码 ]:
UN 2811 6.1/PG 2

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1(b)

4α-佛波醇-12,13-二癸酸酯文献

Involvement of TRPV1 and TRPV4 channels in migration of rat pulmonary arterial smooth muscle cells.

Pflugers Arch. 464(3) , 261-72, (2012)

Pulmonary hypertension, the main disease of the pulmonary circulation, is characterized by an increase in pulmonary vascular resistance, involving proliferation and migration of pulmonary arterial smo...

Ca2+ entry via alpha1G and TRPV4 channels differentially regulates surface expression of P-selectin and barrier integrity in pulmonary capillary endothelium.

Am. J. Physiol. Lung Cell. Mol. Physiol. 297(4) , L650-7, (2009)

Pulmonary vascular endothelial cells express a variety of ion channels that mediate Ca(2+) influx in response to diverse environmental stimuli. However, it is not clear whether Ca(2+) influx from disc...

Salt intake augments hypotensive effects of transient receptor potential vanilloid 4: functional significance and implication.

Hypertension 53(2) , 228-35, (2009)

To test the hypothesis that activation of the transient receptor potential vanilloid 4 (TRPV4) channel conveys a hypotensive effect that is enhanced during salt load, male Wistar rats fed a normal-sod...

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