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甘油磷酰胆碱

甘油磷酰胆碱用途

L-Alpha glycerylphosphorylcholine (alpha-GPC, choline alfoscerate)是存在于脑和奶中的天然胆碱化合物,也是拟副交感神经乙酰胆碱前体。

甘油磷酰胆碱名称

[ CAS 号 ]:
28319-77-9

[ 中文名 ]:
甘磷酸胆碱

[ 英文名 ]:
Choline glycerophosphate

[中文别名 ]:

[英文别名 ]:

L-α-Glycerophosphocholine
α-GPC
L-a-Glycerylphosphorylcholine
L-α-Glycerophosphorylcholine
Choline Alfoscerate
cholini alfosceras
sn-Glycero-3-phosphocholine
MFCD00063544
alfoscerato de colina
EINECS 248-962-2

甘油磷酰胆碱生物活性

[ 描述 ]:

L-Alpha glycerylphosphorylcholine (alpha-GPC, choline alfoscerate)是存在于脑和奶中的天然胆碱化合物,也是拟副交感神经乙酰胆碱前体。

[ 相关类别 ]:

信号通路 >> 神经信号通路 >> 疼痛

天然产物 >> 其他

研究领域 >> 神经疾病

[ 靶点 ]

Human Endogenous Metabolite

[参考文献]

[1]. Parnetti L, et al. Cholinergic precursors in the treatment of cognitive impairment of vascular origin: ineffective approaches or need for re-evaluation J Neurol Sci. 2007 Jun 15;257(1-2):264-9.

[2]. Barbagallo Sangiorgi G, et al. Alpha-Glycerophosphocholine in the mental recovery of cerebral ischemic attacks." An Italian multicenter clinical trial. Ann NY Acad Sci 1994; 717:253-69.

[相关活性小分子]

甘油磷酰胆碱物理化学性质

[ 熔点 ]:
-98ºC

[ 分子式 ]:
C₈H₂₀NO₆P

[ 分子量 ]:
257.221

[ 闪点 ]:
11 °C

[ 精确质量 ]:
257.102814

[ PSA ]:
108.86000

[ LogP ]:
-5.63

[ 外观性状 ]:
solid

[ 折射率 ]:
1.329 (20ºC)

[ 储存条件 ]:
−20°C

甘油磷酰胆碱毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: KH2775000

CHEMICAL NAME :: Ethanaminium, 2-(((2,3-dihydroxypropoxy)hydroxyphosphinyl)oxy)-N,N, N-trimethyl-, hydroxide, inner salt, (R)-

CAS REGISTRY NUMBER :: 28319-77-9

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C8-H20-N-O6-P

MOLECULAR WEIGHT :: 257.26

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >13 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JKXXAF Japanese Kokai Tokyo Koho Patents. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #93-32553

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >650 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JKXXAF Japanese Kokai Tokyo Koho Patents. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #93-32553

甘油磷酰胆碱安全信息

[ 危害码 (欧洲) ]:
F: Flammable;T: Toxic;

[ 风险声明 (欧洲) ]:
R11

[ 安全声明 (欧洲) ]:
S16-S36/37-S45

[ 危险品运输编码 ]:
UN 1230 3/PG 2

[ WGK德国 ]:
2

[ RTECS号 ]:
KH2775000

[ 包装等级 ]:
II

[ 海关编码 ]:
2923900090

甘油磷酰胆碱合成路线

详细合成路线

甘油磷酰胆碱海关

[ 海关编码 ]: 2923900090

[ 中文概述 ]:
2923900090 其他季铵盐及季铵碱。监管条件:无。增值税率:17.0%。退税率:9.0%。最惠国关税:6.5%。普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2923900090 other quaternary ammonium salts and hydroxides。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%