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吡嗪

吡嗪用途

用作医药中间体，香精、香料中间体

吡嗪名称

[ CAS 号 ]:
290-37-9

[ 中文名 ]:
吡嗪

[ 英文名 ]:
Pyrazine

[中文别名 ]:

[英文别名 ]:

Paradiazine
EINECS 206-027-6
Piazine
MFCD00006122
1,4-Diazabenzene
Pyrazine
1,4-Diazine
p-Diazine

吡嗪物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
118.6±13.0 °C at 760 mmHg

[ 熔点 ]:
50-56 °C(lit.)

[ 分子式 ]:
C₄H₄N₂

[ 分子量 ]:
80.088

[ 闪点 ]:
55.6±0.0 °C

[ 精确质量 ]:
80.037445

[ PSA ]:
25.78000

[ LogP ]:
-0.28

[ 外观性状 ]:
吡嗪(290-37-9)两个氮原子占1,2两位的称为哒嗪；占1,3两位的称为嘧啶,它们都是吡嗪的同分异构体。吡嗪是无色晶体，熔点54℃，沸点115～116℃（768毫米汞柱），液态的相对密度1.0311（61／4℃）。具有与吡啶类似的气味。溶于水、乙醇、乙醚等。吡嗪是一个很弱的碱。它的芳香性与吡啶类似，很不容易发生亲电取代反应，而对亲核试剂比较活泼。碳原子上的氢被甲基或卤素取代后，卤素或甲基上的氢具有活性。吡嗪及其衍生物可用多种方法合成。

[ 蒸汽压 ]:
19.7±0.2 mmHg at 25°C

[ 折射率 ]:
1.503

[ 储存条件 ]:
Flammables area

[ 稳定性 ]:
Stable. Highly flammable. Incompatible with acids, oxidizing agents.

[ 水溶解性 ]:
SOLUBLE

吡嗪MSDS

详细MSDS(安全技术说明书)

吡嗪毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UQ2015000

CHEMICAL NAME :: Pyrazine

CAS REGISTRY NUMBER :: 290-37-9

LAST UPDATED :: 199710

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C4-H4-N2

MOLECULAR WEIGHT :: 80.10

WISWESSER LINE NOTATION :: T6N DNJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2730 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: Cytogenetic analysis

TEST SYSTEM :: Rodent - hamster Ovary

DOSE/DURATION :: 2500 mg/L

REFERENCE :: FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 18,581,1980 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X5605 No. of Facilities: 3 (estimated) No. of Industries: 1 No. of Occupations: 3 No. of Employees: 61 (estimated) No. of Female Employees: 3 (estimated)

吡嗪安全信息

[ 符号 ]:

GHS02, GHS07

[ 信号词 ]:
Danger

[ 危害声明 ]:
H228-H315-H319-H335

[ 警示性声明 ]:
P210-P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi,F

[ 风险声明 (欧洲) ]:
R36/37/38:Irritating to eyes, respiratory system and skin . R11:Highly Flammable.

[ 安全声明 (欧洲) ]:
S26-S36-S16

[ 危险品运输编码 ]:
UN 1325 4.1/PG 2

[ WGK德国 ]:
3

[ RTECS号 ]:
UQ2015000

[ 包装等级 ]:
III

[ 危险类别 ]:
4.1

[ 海关编码 ]:
29339990

吡嗪合成路线

详细合成路线

吡嗪上下游产品

吡嗪上游产品

吡嗪下游产品

吡嗪制备

可由β-羟基乙氨基乙胺、N-羟乙基乙二胺（ＨＯＣＨ２ＣＨ２ＮＨＣＨ２ＣＨ２ＮＨ２）在Ｎｉ／Ａｌ２Ｏ３存在下经高温脱氢制取。

吡嗪海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

吡嗪文献

The Inhibition of Maillard Browning by Different Concentrations of Rosmarinic Acid and Epigallocatechin-3-Gallate in Model, Bakery, and Fruit Systems.

J. Food Sci. 80 , C2140-6, (2015)

Rosmarinic acid and Epigallocatechin gallate concentrations were studied as natural inhibitors of Maillard browning in glucose/glycine model systems, and in bakery rolls and applesauce. The concentrat...

Influence of Free Amino Acids, Oligopeptides, and Polypeptides on the Formation of Pyrazines in Maillard Model Systems.

J. Agric. Food Chem. 63 , 5364-72, (2015)

Pyrazines are specific Maillard reaction compounds known to contribute to the unique aroma of many products. Most studies concerning the generation of pyrazines in the Maillard reaction have focused o...

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吡嗪