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7-硝基吲唑

7-硝基吲唑用途

7-硝基吲唑是一种选择性nNOS抑制剂,具有抗伤害和心血管作用。7-硝基吲唑是评估一氧化氮在中枢神经系统中生物学作用的有用工具[1][2]。

7-硝基吲唑名称

[ CAS 号 ]:
2942-42-9

[ 中文名 ]:
7-硝基吲唑

[ 英文名 ]:
7-Nitroindazole

[中文别名 ]:

[英文别名 ]:

1H-Indazole,7-nitro
MFCD00022789
nitro-7 indazole
7-Nitroindazole
7-NI
2H-Indazole, 7-nitro-
7-Nitro-1H-indazole
7-Nitro-2H-indazole
EINECS 220-934-4

7-硝基吲唑生物活性

[ 描述 ]:

7-硝基吲唑是一种选择性nNOS抑制剂,具有抗伤害和心血管作用。7-硝基吲唑是评估一氧化氮在中枢神经系统中生物学作用的有用工具[1][2]。

[ 相关类别 ]:

研究领域 >> 心血管疾病

信号通路 >> 免疫及炎症 >> 一氧化氮合酶

研究领域 >> 神经疾病

[参考文献]

[1]. Moore PK, et al. 7-Nitro indazole, an inhibitor of nitric oxide synthase, exhibits anti-nociceptive activity in the mouse without increasing blood pressure. Br J Pharmacol. 1993 Feb;108(2):296-7.

[2]. Moore PK, et al. Characterization of the novel nitric oxide synthase inhibitor 7-nitro indazole and related indazoles: antinociceptive and cardiovascular effects. Br J Pharmacol. 1993 Sep;110(1):219-24.

7-硝基吲唑物理化学性质

[ 密度 ]:
1.5±0.1 g/cm3

[ 沸点 ]:
211.2±23.0 °C at 760 mmHg

[ 熔点 ]:
185-186°C

[ 分子式 ]:
C₇H₅N₃O₂

[ 分子量 ]:
163.133

[ 闪点 ]:
81.5±22.6 °C

[ 精确质量 ]:
163.038177

[ PSA ]:
74.50000

[ LogP ]:
1.42

[ 外观性状 ]:
橙色-黄色固体

[ 蒸汽压 ]:
0.2±0.4 mmHg at 25°C

[ 折射率 ]:
1.741

[ 储存条件 ]:
−20°C

[ 水溶解性 ]:
slightly soluble

7-硝基吲唑MSDS

7-硝基吲唑毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NK7962200

CHEMICAL NAME :: 1H-Indazole, 7-nitro-

CAS REGISTRY NUMBER :: 2942-42-9

BEILSTEIN REFERENCE NO. :: 0006809

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C7-H5-N3-O2

MOLECULAR WEIGHT :: 163.15

WISWESSER LINE NOTATION :: T56 BMNJ INW

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Salmonella typhimurium

DOSE/DURATION :: 100 nmol/plate

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 173,169,1986

7-硝基吲唑安全信息

[ 符号 ]:

GHS06, GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H301-H319-H351-H360

[ 警示性声明 ]:
P201-P281-P301 + P310-P305 + P351 + P338-P308 + P313

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
T:Toxic;

[ 风险声明 (欧洲) ]:
R60;R40

[ 安全声明 (欧洲) ]:
S53-S22-S36/37/39-S45

[ 危险品运输编码 ]:
UN 2811 6.1/PG 3

[ WGK德国 ]:
3

[ RTECS号 ]:
NK7962200

[ 危险类别 ]:
6.1

[ 海关编码 ]:
2933990090

7-硝基吲唑合成路线

7-硝基吲唑上下游产品

7-硝基吲唑上游产品

7-硝基吲唑下游产品

7-硝基吲唑海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

7-硝基吲唑文献

Effects of prolonged neuronal nitric oxide synthase inhibition on the development and expression of L-DOPA-induced dyskinesia in 6-OHDA-lesioned rats.

Neuropharmacology 89 , 87-99, (2014)

It is well known that nitric oxide (NO) interacts with dopamine (DA) within the striatal circuitry. The anti-dyskinetic properties of NO synthase (NOS) inhibitors demonstrate the importance of NO in L...

Tapentadol and nitric oxide synthase systems.

Behav. Pharmacol. 26(3) , 282-8, (2015)

Tapentadol, a new analgesic drug with a dual mechanism of action (μ-opioid receptor agonism and norepinephrine reuptake inhibition), is indicated for the treatment of moderate to severe acute and chro...

Why Small Differences Matter: Elucidation of the Mechanisms Underlying the Transformation of 2OH- and 3OH-Carbamazepine in Contact with Sand Filter Material.

Environ. Sci. Technol. 49 , 10449-56, (2015)

Carbamazepine (CBZ) is a worldwide used antiepileptic drug, which is metabolized to a large extent in the human body to several metabolites, including 10,11-dihydroxy-10,11-dihydrocarbamazepine (DiOHC...

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