去甲氯丙咪嗪盐酸

去甲氯丙咪嗪盐酸用途

N-Desmethyl Clomipramine hydrochloride (Desmethylclomipramine hydrochloride) 是 Clomipramine 在血浆中 N-去甲基化的主要代谢产物。Clomipramine 是一种三环抗抑郁药。

去甲氯丙咪嗪盐酸名称

[ CAS 号 ]:
29854-14-6

[ 中文名 ]:
去甲氯丙咪嗪盐酸

[ 英文名 ]:
N-Desmethyl Clomipramine Hydrochloride

去甲氯丙咪嗪盐酸生物活性

[ 描述 ]:

N-Desmethyl Clomipramine hydrochloride (Desmethylclomipramine hydrochloride) 是 Clomipramine 在血浆中 N-去甲基化的主要代谢产物。Clomipramine 是一种三环抗抑郁药。

[ 相关类别 ]:

研究领域 >> 神经疾病

[参考文献]

[1]. Sioufi A, et al. Simultaneous determination of clomipramine and its N-desmethyl metabolite in human whole blood by capillary gas chromatography with mass-selective detection. J Chromatogr. 1988 Jun 24;428(1):71-80.

[2]. Härtter S, et al. Non-competitive inhibition of clomipramine N-demethylation by fluvoxamine. Psychopharmacology (Berl). 1995 Jan;117(2):149-53.

去甲氯丙咪嗪盐酸物理化学性质

[ 沸点 ]:
466ºC at 760 mmHg

[ 熔点 ]:
204-206°C (dec.)

[ 分子式 ]:
C₁₈H₂₂Cl₂N₂

[ 分子量 ]:
337.28700

[ 闪点 ]:
235.6ºC

[ 精确质量 ]:
336.11600

[ PSA ]:
15.27000

[ LogP ]:
5.44410

[ 蒸汽压 ]:
4.41E-09mmHg at 25°C

[ 储存条件 ]:
-20°C Freezer

去甲氯丙咪嗪盐酸MSDS

详细MSDS(安全技术说明书)

去甲氯丙咪嗪盐酸安全信息

[ 符号 ]:

GHS02, GHS06, GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H225-H301 + H311 + H331-H370

[ 警示性声明 ]:
P210-P260-P280-P301 + P310-P311

[ 危害码 (欧洲) ]:
F,T

[ 风险声明 (欧洲) ]:
11-23/24/25-39/23/24/25

[ 安全声明 (欧洲) ]:
7-16-36/37-45

[ 危险品运输编码 ]:
UN1230 - class 3 - PG 2 - Methanol, solution

去甲氯丙咪嗪盐酸文献

Steady state concentrations of clomipramine and its major metabolite desmethylclomipramine in rat brain and serum after oral administration of clomipramine.

Eur. Neuropsychopharmacol. 10(5) , 401-5, (2000)

Twenty male Sprague-Dawley rats received five oral doses of clomipramine 20 mg/kg at 4-h intervals. The animals were decapitated 1, 2, 3, 5 and 12 h after the last dose for determination of clomiprami...

Clinical significance of plasma levels of clomipramine, its hydroxylated and desmethylated metabolites: prediction of clinical outcome in mood disorders using discriminant analysis of therapeutic drug monitoring data.

J. Affect. Disord. 29(4) , 267-79, (1993)

We measured the plasma concentrations of clomipramine and its metabolites, N-desmethylclompiramine, 8-hydroxy-N-desmethylclomipramine, 8-hydroxyclomipramine in 65 depressed patients with subtypes of D...

Pharmacokinetics of clomipramine in dogs following single-dose and repeated-dose oral administration.

Am. J. Vet. Res. 61(1) , 80-5, (2000)

To determine pharmacokinetics of clomipramine and its principle metabolite (desmethylclomipramine) in the plasma of dogs following single-dose and repeated-dose oral administration at various dosages....

更多文献