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扁桃苷; 苦杏仁甙

扁桃苷; 苦杏仁甙用途

扁桃素是从蔷薇果实的果核中分离的植物葡萄糖苷,例如杏,桃,杏仁,樱桃和李子。

扁桃苷; 苦杏仁甙名称

[ CAS 号 ]:
29883-15-6

[ 中文名 ]:
扁桃苷

[ 英文名 ]:
Amygdalin

[中文别名 ]:

[英文别名 ]:

Mandelonitrile b-Glucuronide
Vitamin B17
rile
Mygdalin
D-amygdalin
EINECS 249-925-3
Mandelonitrile-b-gentiobioside
amygdaloside
D-Mandelonitrile 6-O-β-D-glucosido-β-D-glucoside
D-AMYGLADIN

扁桃苷; 苦杏仁甙生物活性

[ 描述 ]:

扁桃素是从蔷薇果实的果核中分离的植物葡萄糖苷,例如杏,桃,杏仁,樱桃和李子。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 癌症

天然产物 >> 糖和糖苷

[体外研究]

Amygdalin具有抗肿瘤活性。关于苦杏仁苷的抗肿瘤机制已取得一些进展[1]。苦杏仁苷特别下调属于细胞周期类别的基因：外切核酸酶1,ATP结合盒,亚家族F,成员2,MRE11减数分裂重组11同源物A,拓扑异构酶(DNA)I和FK506结合蛋白12-雷帕霉素相关蛋白1 RT-PCR分析显示,在SNU-C4人结肠癌细胞中,苦杏仁苷处理也会降低这些基因的mRNA水平[2]。

[体内研究]

苦杏仁苷可有效缓解炎症疼痛,并可用作具有抗伤害性和抗炎活性的镇痛药。肌肉注射苦杏仁苷在早期(福尔马林注射后最初10分钟)和晚期(最初福尔马林注射后10-30分钟)显着降低福尔马林诱导的强直性疼痛。在晚期,苦杏仁苷以剂量依赖性方式减少福尔马林诱导的疼痛,剂量范围小于1 mg/kg [3]。

[细胞实验]

通过MTT测定确定细胞活力。将细胞以1×10 5个细胞/孔的浓度一式三份接种在96孔板上。用浓度为0.25,0.5,2.5和5mg / mL的苦杏仁苷处理SNU-C4细胞24小时。将MTT加入各组后，将细胞培养4小时。然后，将它们进一步温育1小时，包括溶解MTT的溶液[2]。

[动物实验]

大鼠：将苦杏仁苷粉末溶解在盐水中并用适当的培养基稀释。将重230-250g的雄性Sprague-Dawley大鼠用于该实验。注射50mL的5％福尔马林以在大鼠中产生fomalin诱导的疼痛。在福尔马林注射诱导疼痛前30分钟，给予大鼠肌肉注射苦杏仁苷溶液（0.1,0.5,1.0,10mg / kg）或盐水作为媒介物对照[3]。

[参考文献]

[1]. Song Z, et al. Advanced research on anti-tumor effects of amygdalin. J Cancer Res Ther. 2014 Aug;10 Suppl 1:3-7.

[2]. Park HJ,et al. Amygdalin inhibits genes related to cell cycle in SNU-C4 human colon cancer cells. World J Gastroenterol. 2005 Sep 7;11(33):5156-61.

[3]. Hwang HJ,et al. Antinociceptive effect of amygdalin isolated from Prunus armeniaca on formalin-induced pain in rats. Biol Pharm Bull. 2008 Aug;31(8):1559-64.

[相关活性小分子]

扁桃苷; 苦杏仁甙物理化学性质

[ 密度 ]:
1.6±0.1 g/cm3

[ 沸点 ]:
743.3±60.0 °C at 760 mmHg

[ 熔点 ]:
223-226 °C(lit.)

[ 分子式 ]:
C₂₀H₂₇NO₁₁

[ 分子量 ]:
457.428

[ 闪点 ]:
403.3±32.9 °C

[ 精确质量 ]:
457.158417

[ PSA ]:
202.32000

[ LogP ]:
-0.36

[ 外观性状 ]:
白色细结晶粉末

[ 蒸汽压 ]:
0.0±2.6 mmHg at 25°C

[ 折射率 ]:
1.650

[ 储存条件 ]:
库房通风低温干燥

[ 水溶解性 ]:
83 g/L (25 ºC)

扁桃苷; 苦杏仁甙MSDS

详细MSDS(安全技术说明书)

扁桃苷; 苦杏仁甙毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: OO8450000

CHEMICAL NAME :: D(-)-Mandelonitrile-beta-D-gentiobioside

CAS REGISTRY NUMBER :: 29883-15-6

BEILSTEIN REFERENCE NO. :: 0066856

LAST UPDATED :: 199612

DATA ITEMS CITED :: 10

MOLECULAR FORMULA :: C20-H27-N-O11

MOLECULAR WEIGHT :: 457.48

WISWESSER LINE NOTATION :: T6OTJ BOYR&CN CQ DQ EQ F1O- BT6OTJ CQ DQ EQ F1Q -D(-)

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - infant

DOSE/DURATION :: 50 mg/kg

TOXIC EFFECTS :: Behavioral - coma Lungs, Thorax, or Respiration - dyspnea Gastrointestinal - nausea or vomiting

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 405 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 443 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory stimulation

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Primate - monkey

DOSE/DURATION :: 167 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - dyspnea Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 6 gm/kg/30D-I

TOXIC EFFECTS :: Blood - pigmented or nucleated red blood cells Blood - changes in erythrocyte (RBC) count Blood - changes in leukocyte (WBC) count

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 300 mg/kg

SEX/DURATION :: female 8 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Specific Developmental Abnormalities - musculoskeletal system

MUTATION DATA

TYPE OF TEST :: Host-mediated assay

TEST SYSTEM :: Rodent - mouse Bacteria - Salmonella typhimurium

DOSE/DURATION :: 250 mg/kg

REFERENCE :: SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H St., NW, Washington, DC 20005) V.1- 1895- Volume(issue)/page/year: 198,625,1977 *** REVIEWS *** TOXICOLOGY REVIEW CTOXAO Clinical Toxicology. (New York, NY) V.1-18, 1968-81. For publisher information, see JTCTDW. Volume(issue)/page/year: 17,85,1980 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X5264 No. of Facilities: 427 (estimated) No. of Industries: 1 No. of Occupations: 5 No. of Employees: 3566 (estimated) No. of Female Employees: 2900 (estimated)

扁桃苷; 苦杏仁甙安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ 危害码 (欧洲) ]:
Xn:Harmful

[ 风险声明 (欧洲) ]:
R22

[ 安全声明 (欧洲) ]:
S26-S36/37/39-S45

[ 危险品运输编码 ]:
2811

[ WGK德国 ]:
3

[ RTECS号 ]:
OO8450000

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1(b)

扁桃苷; 苦杏仁甙上下游产品

扁桃苷; 苦杏仁甙上游产品

扁桃苷; 苦杏仁甙下游产品

扁桃苷; 苦杏仁甙文献

Synthesis and Characterization of Hapten-Protein Conjugates for Antibody Production against Cyanogenic Glycosides.

J. Food Prot. 78 , 1408-13, (2015)

Consumption of cyanogenic plants can cause serious health problems for humans. The ability to detect and quantify cyanogenic glycosides, capable of generating cyanide, could contribute to prevention o...

Anti-inflammatory actions of herbal formula Gyejibokryeong-hwan regulated by inhibiting chemokine production and STAT1 activation in HaCaT cells.

Biol. Pharm. Bull. 38(3) , 425-34, (2015)

Gyejibokryeong-hwan (GJBRH; Keishi-bukuryo-gan in Japan and Guizhi Fuling Wan in China) is a traditional herbal formula comprising five medicinal herbs and is used to treat climacteric syndrome. GJBRH...

Optimization of technological procedure for amygdalin isolation from plum seeds (Pruni domesticae semen).

Front. Plant Sci. 6 , 276, (2015)

The process of amygdalin extraction from plum seeds was optimized using central composite design (CCD) and multilayer perceptron (MLP). The effect of time, ethanol concentration, solid-to-liquid ratio...

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