<生产厂家价格>

氢溴酸槟榔碱

氢溴酸槟榔碱用途

Arecoline氢溴酸盐是毒蕈碱乙酰胆碱受体(mAChR)激动剂。

氢溴酸槟榔碱名称

[ CAS 号 ]:
300-08-3

[ 中文名 ]:
氢溴酸槟榔碱

[ 英文名 ]:
Arecoline hydrobromide

[中文别名 ]:

[英文别名 ]:

MFCD00039041
EINECS 206-087-3
Arecaidine methyl ester hydrobromide
Arecoline
ARECOLINE HBr
arecolinium bromide
Arecoline hydrobromide
Taeniolin
Arecoline bromide
Arecoline (hydrobromide)

氢溴酸槟榔碱生物活性

[ 描述 ]:

Arecoline氢溴酸盐是毒蕈碱乙酰胆碱受体(mAChR)激动剂。

[ 相关类别 ]:

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 由mAChR

信号通路 >> 神经信号通路 >> mAChR

研究领域 >> 神经疾病

[参考文献]

[1]. Ghelardini, C., et al., M1 receptor activation is a requirement for arecoline analgesia. Farmaco, 2001. 56(5-7): p. 383-5.

[2]. Yang, Y.R., et al., Arecoline excites rat locus coeruleus neurons by activating the M2-muscarinic receptor. Chin J Physiol, 2000. 43(1): p. 23-8.

[3]. Xie, D.P., et al., Arecoline excites the colonic smooth muscle motility via M3 receptor in rabbits. Chin J Physiol, 2004. 47(2): p. 89-94.

[相关活性小分子]

氢溴酸槟榔碱物理化学性质

[ 沸点 ]:
209ºC at 760mmHg

[ 熔点 ]:
171-175 °C

[ 分子式 ]:
C₈H₁₄BrNO₂

[ 分子量 ]:
236.106

[ 闪点 ]:
81.1ºC

[ 精确质量 ]:
235.020782

[ PSA ]:
29.54000

[ LogP ]:
1.31730

[ 外观性状 ]:
白色细粉末

[ 储存条件 ]:
Refrigerator

[ 水溶解性 ]:
H2O: 0.1 g/mL, clear, colorless

氢溴酸槟榔碱MSDS

详细MSDS(安全技术说明书)

氢溴酸槟榔碱毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: QT2275000

CHEMICAL NAME :: Nicotinic acid, 1,2,5,6-tetrahydro-1-methyl-, methyl ester, hydrobromide

CAS REGISTRY NUMBER :: 300-08-3

LAST UPDATED :: 199012

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C8-H13-N-O2.Br-H

MOLECULAR WEIGHT :: 236.14

WISWESSER LINE NOTATION :: T6N CUTJ A1 CVO1 &EH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Parenteral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 270 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ABMGAJ Acta Biologica et Medica Germanica. (Berlin, Ger. Dem. Rep.) V.1-41, 1958-82. For publisher information, see BBIADT. Volume(issue)/page/year: 28,681,1972

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 65 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 35,75,1929

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 18 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#11778

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Parenteral

SPECIES OBSERVED :: Amphibian - frog

DOSE/DURATION :: 160 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ABMGAJ Acta Biologica et Medica Germanica. (Berlin, Ger. Dem. Rep.) V.1-41, 1958-82. For publisher information, see BBIADT. Volume(issue)/page/year: 28,681,1972

氢溴酸槟榔碱安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302

[ 警示性声明 ]:
P301 + P312 + P330

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn:Harmful;

[ 风险声明 (欧洲) ]:
R22

[ 安全声明 (欧洲) ]:
S45-S38-S36/37/39-S28A

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
QT2275000

[ 海关编码 ]:
29399990

氢溴酸槟榔碱上下游产品

氢溴酸槟榔碱上游产品

氢溴酸槟榔碱下游产品

氢溴酸槟榔碱海关

[ 海关编码 ]: 2933399090

[ 中文概述 ]:
2933399090. 其他结构含非稠合吡啶环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

氢溴酸槟榔碱文献

Determination and pharmacokinetic studies of arecoline in dog plasma by liquid chromatography-tandem mass spectrometry.

J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 969 , 12-8, (2014)

A rapid and sensitive high-performance liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed and validated for the determination of arecoline concentration in dog plasma. Plas...

Arecoline is cytotoxic for human endothelial cells.

J. Oral. Pathol. Med. 43(10) , 761-9, (2014)

Oral submucous fibrosis is a pre-malignant fibrotic condition caused by areca nut use and involves reduced mucosal vascularity. Arecoline is the principal areca nut alkaloid and is cytotoxic for epith...

更多文献