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D,L-赤型-二氢鞘氨醇

D,L-赤型-二氢鞘氨醇用途

DL-红二氢鞘氨醇是PKC和磷脂酶A2(PLA2)的有效抑制剂[1][2]。

D,L-赤型-二氢鞘氨醇名称

[ CAS 号 ]:
3102-56-5

[ 中文名 ]:
DL-赤型-二氢神经胺

[ 英文名 ]:
D,L-erythro-Dihydrosphingosine

[中文别名 ]:

[英文别名 ]:

EINECS 212-116-0
DL-ERYTHRO-DIHYDROSPHINGOSINE
MFCD00079141

D,L-赤型-二氢鞘氨醇生物活性

[ 描述 ]:

DL-红二氢鞘氨醇是PKC和磷脂酶A2(PLA2)的有效抑制剂[1][2]。

[ 相关类别 ]:

信号通路 >> 表观遗传学 >> PKC

研究领域 >> 癌症

信号通路 >> 代谢酶/蛋白酶 >> 磷脂

信号通路 >> TGF-beta/Smad 信号通路 >> PKC

[参考文献]

[1]. R Chao, et al. Retinoblastoma protein dephosphorylation induced by D-erythro-sphingosine. J Biol Chem. 1992 Nov 25;267(33):23459-62.

[2]. Hiroyuki Nakamura, et al. Inhibition of arachidonic acid release and cytosolic phospholipase A2 alpha activity by D-erythro-sphingosine. Eur J Pharmacol. 2004 Jan 19;484(1):9-17.

D,L-赤型-二氢鞘氨醇物理化学性质

[ 密度 ]:
0.927g/cm3

[ 沸点 ]:
446.2ºC at 760 mmHg

[ 熔点 ]:
70-72ºC

[ 分子式 ]:
C₁₈H₃₉NO₂

[ 分子量 ]:
301.50800

[ 闪点 ]:
223.7ºC

[ 精确质量 ]:
301.29800

[ PSA ]:
66.48000

[ LogP ]:
4.84850

[ 外观性状 ]:
white

[ 折射率 ]:
1.477

[ 储存条件 ]:
−20°C

[ 水溶解性 ]:
chloroform/methanol (9:1): 20 mg/mL, clear, colorless to faintly yellow

D,L-赤型-二氢鞘氨醇MSDS

详细MSDS(安全技术说明书)

D,L-赤型-二氢鞘氨醇安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ 海关编码 ]:
2922199090

D,L-赤型-二氢鞘氨醇上下游产品

D,L-赤型-二氢鞘氨醇上游产品

D,L-赤型-二氢鞘氨醇下游产品

D,L-赤型-二氢鞘氨醇海关

[ 海关编码 ]: 2922199090

[ 中文概述 ]:
2922199090. 其他氨基醇及其醚，酯和它们的盐（但含一种以上含氧基的除外）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装

[ Summary ]:
2922199090. other amino-alcohols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

D,L-赤型-二氢鞘氨醇文献

Early and late HIV-1 membrane fusion events are impaired by sphinganine lipidated peptides that target the fusion site.

Biochem. J. 461(2) , 213-22, (2014)

Lipid-conjugated peptides have advanced the understanding of membrane protein functions and the roles of lipids in the membrane milieu. These lipopeptides modulate various biological systems such as v...

Myriocin, an inhibitor of serine palmitoyl transferase, impairs the uptake of transferrin and low-density lipoprotein in mammalian cells.

Arch. Biochem. Biophys. 526(1) , 60-8, (2012)

The role of sphingolipids in clathrin-mediated endocytosis is only poorly understood in mammalian cells. Thus the relationship between sphingolipid de novo synthesis and clathrin-mediated endocytosis ...

Terpene alcohols inhibit de novo sphingolipid biosynthesis.

Planta Med. 78(5) , 434-9, (2012)

The terpene alcohols geranyllinalool, phytol (diterpene alcohol), and farnesol (sesquiterpene alcohol) were newly found to inhibit sphingolipid de novo biosynthesis in LLC-PK₁ cells (pig kidney epithe...

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