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4-羟雌甾酮

4-羟雌甾酮用途

4-羟基雌酮(4-OHE1)是一种雌酮代谢产物,对氧化神经毒性具有很强的神经保护作用。4-羟基雌酮增加了由SIRT1介导的p53脱乙酰化引起的p53的细胞质易位。4-羟基雌激素几乎没有雌激素活性[1]。

4-羟雌甾酮名称

[ CAS 号 ]:
3131-23-5

[ 中文名 ]:
4-羟雌甾酮

[ 英文名 ]:
4-hydroxyestrone

[中文别名 ]:

[英文别名 ]:

4-Hydroxy Estrone
MFCD00079358
4-HydroxyEstrone

4-羟雌甾酮生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 神经疾病

[ 靶点 ]

Human Endogenous Metabolite

[参考文献]

[1]. Hye Joung Choi, et al. 4-Hydroxyestrone, an Endogenous Estrogen Metabolite, Can Strongly Protect Neuronal Cells Against Oxidative Damage. Sci Rep. 2020 Apr 29;10(1):7283.

4-羟雌甾酮物理化学性质

[ 密度 ]:
1.241g/cm3

[ 沸点 ]:
468.2ºC at 760mmHg

[ 熔点 ]:
260-263ºC

[ 分子式 ]:
C₁₈H₂₂O₃

[ 分子量 ]:
286.36500

[ 闪点 ]:
251.1ºC

[ 精确质量 ]:
286.15700

[ PSA ]:
57.53000

[ LogP ]:
3.52300

[ 折射率 ]:
1.61

[ 储存条件 ]:
2-8°C

4-羟雌甾酮毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: KG7749500

CHEMICAL NAME :: Estra-1,3,5(10)-trien-17-one, 3,4-dihydroxy-

CAS REGISTRY NUMBER :: 3131-23-5

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C18-H22-O3

MOLECULAR WEIGHT :: 286.40

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 30 mg/kg

SEX/DURATION :: female 1-6 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)

REFERENCE :: STEDAM Steroids. (Holden-Day Inc., 4432 Telegraph Ave., Oakland, CA 94609) V.1- 1963- Volume(issue)/page/year: 30,343,1977

4-羟雌甾酮安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
KG7749500

4-羟雌甾酮上下游产品

4-羟雌甾酮上游产品

4-羟雌甾酮下游产品

4-羟雌甾酮文献

Improved profiling of estrogen metabolites by orbitrap LC/MS.

Steroids 99 , 84-90, (2015)

Estrogen metabolites are important biomarkers to evaluate cancer risks and metabolic diseases. Due to their low physiological levels, a sensitive and accurate method is required, especially for the qu...

Redox cycling of catechol estrogens generating apurinic/apyrimidinic sites and 8-oxo-deoxyguanosine via reactive oxygen species differentiates equine and human estrogens.

Chem. Res. Toxicol. 23(8) , 1365-73, (2010)

Metabolic activation of estrogens to catechols and further oxidation to highly reactive o-quinones generates DNA damage including apurinic/apyrimidinic (AP) sites. 4-Hydroxyequilenin (4-OHEN) is the m...

Menstrual cycle effects on urinary estrogen metabolites.

J. Clin. Endocrinol. Metab. 84(11) , 3914-8, (1999)

Endogenous estrogen metabolism may play an important role in the pathogenesis of hormone-related cancers, most notably breast cancer. Despite the importance of estrogen metabolism, little is known abo...

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