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N-(3-甲基苯基)-4-(4-吡啶)-2-噻唑胺

N-(3-甲基苯基)-4-(4-吡啶)-2-噻唑胺用途

STF-62247是一个TGN抑制剂,在RCC4 和RCC4/VHL细胞中的IC50分别是0.625 μM和16 μM。

N-(3-甲基苯基)-4-(4-吡啶)-2-噻唑胺名称

[ CAS 号 ]:
315702-99-9

[ 中文名 ]:
N-(3-甲基苯基)-4-(4-吡啶)-2-噻唑胺

[ 英文名 ]:
STF-62247

[英文别名 ]:

STF-62247
4-(pyridin-4-yl)-N-m-tolylthiazol-2-amine
N-(3-Methylphenyl)-4-(4-pyridinyl)-2-thiazolamine
S1041_Selleck

N-(3-甲基苯基)-4-(4-吡啶)-2-噻唑胺生物活性

[ 描述 ]:

STF-62247是一个TGN抑制剂,在RCC4 和RCC4/VHL细胞中的IC50分别是0.625 μM和16 μM。

[ 相关类别 ]:

信号通路 >> 自噬 >> 自噬

研究领域 >> 癌症

[参考文献]

[1]. Turcotte, S. et al. A molecule targeting VHL-deficient renal cell carcinoma that induces autophagy. Cancer cell 14, 90-102, doi:10.1016/j.ccr.2008.06.004 (2008)

[2]. Chan, D. A. & Giaccia, A. J. Targeting cancer cells by synthetic lethality: autophagy and VHL in cancer therapeutics. Cell cycle 7, 2987-2990, doi:10.4161/cc.7.19.6776 (2008)

[3]. Anbalagan, S. et al. Radiosensitization of renal cell carcinoma in vitro through the induction of autophagy. Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 103, 388-393, doi:10.1016/j.radonc.2012.04.001 (2012

[相关活性小分子]

N-(3-甲基苯基)-4-(4-吡啶)-2-噻唑胺物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
444.8±47.0 °C at 760 mmHg

[ 熔点 ]:
174.66° C

[ 分子式 ]:
C₁₅H₁₃N₃S

[ 分子量 ]:
267.349

[ 闪点 ]:
222.8±29.3 °C

[ 精确质量 ]:
267.083008

[ PSA ]:
66.05000

[ LogP ]:
3.16

[ 蒸汽压 ]:
0.0±1.1 mmHg at 25°C

[ 折射率 ]:
1.671

[ 储存条件 ]:
-20°C

N-(3-甲基苯基)-4-(4-吡啶)-2-噻唑胺MSDS

详细MSDS(安全技术说明书)

N-(3-甲基苯基)-4-(4-吡啶)-2-噻唑胺安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H319

[ 警示性声明 ]:
P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves;type P2 (EN 143) respirator cartridges

[ 危险品运输编码 ]:
NONH for all modes of transport

N-(3-甲基苯基)-4-(4-吡啶)-2-噻唑胺合成路线

详细合成路线

N-(3-甲基苯基)-4-(4-吡啶)-2-噻唑胺上下游产品

N-(3-甲基苯基)-4-(4-吡啶)-2-噻唑胺上游产品

N-(3-甲基苯基)-4-(4-吡啶)-2-噻唑胺下游产品

N-(3-甲基苯基)-4-(4-吡啶)-2-噻唑胺文献

Novel small-molecule SIRT1 inhibitors induce cell death in adult T-cell leukaemia cells.

Sci. Rep. 5 , 11345, (2015)

Adult T-cell leukaemia/lymphoma (ATL) is an aggressive T-cell malignancy that develops after long-term infection with human T-cell leukaemia virus (HTLV)-1. The identification of new molecular targets...

Targeted therapy for the loss of von Hippel-Lindau in renal cell carcinoma: a novel molecule that induces autophagic cell death.

Autophagy 4(7) , 944-6, (2008)

Radiation and conventional cytotoxic chemotherapies are ineffective in treating renal cancer. Approximately 75 percent of renal cell carcinoma (RCC) is associated with an inactivation of the tumor sup...

A novel method for autophagy detection in primary cells: impaired levels of macroautophagy in immunosenescent T cells.

Autophagy 8 , 677-89, (2012)

Autophagy is a conserved constitutive cellular process, responsible for the degradation of dysfunctional proteins and organelles. Autophagy plays a role in many diseases such as neurodegeneration and ...

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