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L-鸟氨酸盐酸盐

L-鸟氨酸盐酸盐用途

L-Ornithine Hydrochloride 是一种游离氨基酸,在尿素循环中有很重要的作用,对过量的氮处理也很重要。

L-鸟氨酸盐酸盐名称

[ CAS 号 ]:
3184-13-2

[ 中文名 ]:
L-鸟氨酸盐酸盐

[ 英文名 ]:
L(+)-Ornithine hydrochloride

[中文别名 ]:

[英文别名 ]:

L-Ornithine, monohydrochloride
H-Orn-OH.HCl
L-Orn hydrochloride
(2S)-2,5-diaminopentanoic acid hydrochloride
L-Ornithine monohydrochloride
L-Ornithine HCl
(S)-2,5-Diaminovaleric acid monohydrochloride
D-ORNITHINE HCL
L(+)-Ornithinehydrochloride
H-Orn-OH·HCl

L-鸟氨酸盐酸盐生物活性

[ 描述 ]:

L-Ornithine Hydrochloride 是一种游离氨基酸,在尿素循环中有很重要的作用,对过量的氮处理也很重要。

[ 相关类别 ]:

天然产物 >> 其他

研究领域 >> 代谢疾病

[ 靶点 ]

Human Endogenous Metabolite

[参考文献]

[1]. Demura S, et al. Effect of L-ornithine hydrochloride ingestion on intermittent maximal anaerobic cycle ergometer performance and fatigue recovery after exercise. Eur J Appl Physiol. 2011 Nov;111(11):2837-43.

[相关活性小分子]

L-鸟氨酸盐酸盐物理化学性质

[ 密度 ]:
1.57

[ 沸点 ]:
308.7ºC at 760 mmHg

[ 熔点 ]:
245 °C (dec.)(lit.)

[ 分子式 ]:
C₅H₁₃ClN₂O₂

[ 分子量 ]:
168.622

[ 闪点 ]:
140.5ºC

[ 精确质量 ]:
168.066559

[ PSA ]:
89.34000

[ LogP ]:
1.33980

[ 外观性状 ]:
白色粉末

[ 折射率 ]:
24 ° (C=4, 6mol/L HCl)

[ 储存条件 ]:
室温

L-鸟氨酸盐酸盐MSDS

L-鸟氨酸盐酸盐毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: RM2985000

CHEMICAL NAME :: Ornithine, monohydrochloride, L-

CAS REGISTRY NUMBER :: 3184-13-2

LAST UPDATED :: 199701

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C5-H12-N2-O2.Cl-H

MOLECULAR WEIGHT :: 168.65

WISWESSER LINE NOTATION :: Z3YZVQ &GH -L

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 10 gm/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Behavioral - ataxia Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961- Volume(issue)/page/year: 62,49,1973 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4776 No. of Facilities: 162 (estimated) No. of Industries: 2 No. of Occupations: 6 No. of Employees: 2955 (estimated) No. of Female Employees: 2312 (estimated)

L-鸟氨酸盐酸盐安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
RM2985000

[ 海关编码 ]:
2922499990

L-鸟氨酸盐酸盐合成路线

L-鸟氨酸盐酸盐上下游产品

L-鸟氨酸盐酸盐上游产品

L-鸟氨酸盐酸盐下游产品

L-鸟氨酸盐酸盐制备

L-鸟氨酸盐酸盐海关

[ 海关编码 ]: 2922499990

[ 中文概述 ]:
2922499990 其他氨基酸及其酯及它们的盐（含有一种以上含氧基的除外）. 增值税率:17.0% 退税率:9.0% 监管条件:AB(入境货物通关单,出境货物通关单) 最惠国关税:6.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装

[ 监管条件 ]: A.入境货物通关单 B.出境货物通关单

[ 检验检疫 ]: P.进境动植物、动植物产品检疫 Q.出境动植物、动植物产品检疫 R.进口食品卫生监督检验 S.出口食品卫生监督检验 M.进口商品检验 N.出口商品检验

[ Summary ]:
HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0%

L-鸟氨酸盐酸盐文献

Increased ornithine-derived polyamines cause airway hyperresponsiveness in a mouse model of asthma.

Am. J. Respir. Cell. Mol. Biol. 48(6) , 694-702, (2013)

Up-regulation of arginase contributes to airways hyperresponsiveness (AHR) in asthma by reducing L-arginine bioavailability for the nitric oxide (NO) synthase isozymes. The product of arginase activit...

Microbacterium kyungheense sp. nov. and Microbacterium jejuense sp. nov., isolated from salty soil.

Int. J. Syst. Evol. Microbiol. 64(Pt 7) , 2267-73, (2014)

Two novel strains, THG-C26(T) and THG-C31(T), were characterized using a polyphasic approach to determine their taxonomic positions. These two isolates were aerobic, Gram-stain-positive, non-motile, n...

Treatment of arginase deficiency revisited: guanidinoacetate as a therapeutic target and biomarker for therapeutic monitoring.

Dev. Med. Child Neurol. 56(10) , 1021-4, (2014)

Hyperargininaemia is a disorder of the last step of the urea cycle. It is an autosomal recessive disease caused by deficiency of liver arginase-1 and usually presents later in childhood with progressi...

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