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TN-16

TN-16用途

TN-16是一种有效的微管聚合抑制剂,IC50为0.4-1.7µM[1]。

TN-16名称

[ CAS 号 ]:
33016-12-5

[ 英文名 ]:
TN-16

[英文别名 ]:

2,3`-ANHYDROTHYMIDINE-D3

TN-16生物活性

[ 描述 ]:

TN-16是一种有效的微管聚合抑制剂,IC50为0.4-1.7µM[1]。

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> 细胞周期/DNA损伤 >> 微管/微管蛋白

信号通路 >> 细胞骨架 >> 微管/微管蛋白

[参考文献]

[1]. Arai T. Inhibition of microtubule assembly in vitro by TN-16, a synthetic antitumor drug. FEBS Lett. 1983 May 8;155(2):273-6.

TN-16物理化学性质

[ 密度 ]:
1.249g/cm3

[ 沸点 ]:
532.7ºC at 760 mmHg

[ 熔点 ]:
182-185 °C

[ 分子式 ]:
C₁₉H₁₈N₂O₂

[ 分子量 ]:
306.35800

[ 闪点 ]:
195.5ºC

[ 精确质量 ]:
306.13700

[ PSA ]:
58.20000

[ LogP ]:
3.08450

[ 折射率 ]:
1.648

[ 储存条件 ]:
2-8℃

TN-16MSDS

详细MSDS(安全技术说明书)

TN-16安全信息

[ 符号 ]:

GHS07, GHS09

[ 信号词 ]:
Warning

[ 危害声明 ]:
H317-H400

[ 警示性声明 ]:
P273-P280

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
43-50/53

[ 安全声明 (欧洲) ]:
36/37-60-61

[ 危险品运输编码 ]:
UN 3077 9 / PGIII

TN-16文献

CENP-C and CENP-I are key connecting factors for kinetochore and CENP-A assembly.

J. Cell Sci. 128 , 4572-87, (2015)

Although it is generally accepted that chromatin containing the histone H3 variant CENP-A is an epigenetic mark maintaining centromere identity, the pathways leading to the formation and maintenance o...

Inhibition of microtubule assembly in vitro by TN-16, a synthetic antitumor drug.

FEBS Lett. 155(2) , 273-6, (1983)

An antitumor drug, 3-(1-anilinoethylidene)-5-benzylpyrrolidine-2,4-dione (TN-16) inhibited the assembly of porcine brain microtubules in vitro. The assembly induced by taxol was also suppressed by the...

Localization of Fas ligand in cytoplasmic granules of CD8+ cytotoxic T lymphocytes and natural killer cells: participation of Fas ligand in granule exocytosis model of cytotoxicity.

Biochem. Biophys. Res. Commun. 296(2) , 328-36, (2002)

Fas ligand (FasL) has been implicated in cytotoxic T lymphocyte (CTL)- and natural killer (NK) cell-mediated cytotoxicity. In the present study, we investigated the localization of FasL in murine CTL ...

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