1,4-丁二胺双盐酸盐

1,4-丁二胺双盐酸盐用途

1,4-Diaminobutane dihydrochloride 是一种内源性代谢物,能作为高等植物大麦和油菜受 Cr (III) 或 Cr (VI) 胁迫引起污染的指标。1,4-Diaminobutane dihydrochloride 是 GABA 的重要来源。

1,4-丁二胺双盐酸盐名称

[ CAS 号 ]:
333-93-7

[ 中文名 ]:
1,4-丁二胺二盐酸盐

[ 英文名 ]:
butane-1,4-diaminium dichloride

[中文别名 ]:

[英文别名 ]:

1,4-DIAMINOBUTANE 2HCL
1,4-BUTANEDIAMMONIUM DICHLORIDE
Putrescin dihydrochloride
TETRAMETHYLENEDIAMINE 2HCL
EINECS 206-375-9
butane-1,4-diamine dihydrochloride
PUTRESCINE HYDROCHLORIDE
Putrescine 2HCl
1,4-Butanediamine, hydrochloride (1:2)
DIAMINOBUTANE DIHYDROCHLORIDE

1,4-丁二胺双盐酸盐生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 其他

[ 靶点 ]

Human Endogenous Metabolite[1]

[体外研究]

1,4-二氨基丁烷是出生后大鼠心室下区GABA的重要来源。从替代途径合成GABA使用1,4-丁二胺作为前体[2]。

[参考文献]

[1]. Hauschild MZ. Putrescine (1,4-diaminobutane) as an indicator of pollution-induced stress in higher plants: barley and rape stressed with Cr(III) or Cr(VI). Ecotoxicol Environ Saf. 1993 Oct;26(2):228-47.

[2]. Sequerra EB, et al. Putrescine as an important source of GABA in the postnatal rat subventricular zone. Neuroscience. 2007 May 11;146(2):489-93.

1,4-丁二胺双盐酸盐物理化学性质

[ 密度 ]:
1.472g/cm3

[ 沸点 ]:
159ºC at 760 mmHg

[ 熔点 ]:
280 °C (dec.)(lit.)

[ 分子式 ]:
C₄H₁₄Cl₂N₂

[ 分子量 ]:
161.073

[ 闪点 ]:
51.7ºC

[ 精确质量 ]:
160.053406

[ PSA ]:
52.04000

[ LogP ]:
2.68860

[ 外观性状 ]:
白色粉末

[ 储存条件 ]:
2-8°C

[ 稳定性 ]:
Stable, but hygroscopic. Substances to be avoided: strong oxidizing agents. Combustible.

[ 水溶解性 ]:
H2O: 100 mg/mL

1,4-丁二胺双盐酸盐MSDS

1,4-丁二胺双盐酸盐毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: EJ7280000

CHEMICAL NAME :: 1,4-Butanediamine, dihydrochloride

CAS REGISTRY NUMBER :: 333-93-7

LAST UPDATED :: 199701

DATA ITEMS CITED :: 9

MOLECULAR FORMULA :: C4-H12-N2.2Cl-H

MOLECULAR WEIGHT :: 161.10

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1625 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - changes in motor activity (specific assay)

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 760 mg/kg

TOXIC EFFECTS :: Behavioral - antipsychotic Lungs, Thorax, or Respiration - respiratory depression Nutritional and Gross Metabolic - body temperature decrease

TYPE OF TEST :: LD30 - Lethal Dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1400 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia Lungs, Thorax, or Respiration - respiratory depression

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1880 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - changes in motor activity (specific assay)

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 510 mg/kg

TOXIC EFFECTS :: Behavioral - antipsychotic Lungs, Thorax, or Respiration - respiratory depression Nutritional and Gross Metabolic - body temperature decrease

MUTATION DATA

TYPE OF TEST :: Cytogenetic analysis

TEST SYSTEM :: Human HeLa cell

DOSE/DURATION :: 2 mmol/L

REFERENCE :: JCLLAX Journal of Cellular Physiology. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.67- 1966- Volume(issue)/page/year: 78,217,1971 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X1000 No. of Facilities: 81 (estimated) No. of Industries: 2 No. of Occupations: 2 No. of Employees: 236 (estimated)

1,4-丁二胺双盐酸盐安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P280-P305 + P351 + P338-P337 + P313

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi:Irritant;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36-S37/39

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
EJ7280000

[ 海关编码 ]:
2921290000

1,4-丁二胺双盐酸盐合成路线

1,4-丁二胺双盐酸盐上下游产品

1,4-丁二胺双盐酸盐上游产品

1,4-丁二胺双盐酸盐下游产品

1,4-丁二胺双盐酸盐制备

由吡咯与盐酸羟胺反应得到丁二肟，再经还原而得丁二胺。

1,4-丁二胺双盐酸盐海关

[ 海关编码 ]: 2921290000

[ 中文概述 ]:
2921290000. 其他无环多胺及其衍生物及它们的盐. 增值税率:17.0%. 退税率:9.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2921290000 other acyclic polyamines and their derivatives; salts thereof。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

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