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胞磷胆碱钠

胞磷胆碱钠用途

Cytidoline sodium salt 是一种合成细胞膜组分磷脂酰胆碱的中间体, 且发挥神经保护作用。

胞磷胆碱钠名称

[ CAS 号 ]:
33818-15-4

[ 中文名 ]:
胞磷胆碱钠

[ 英文名 ]:
Citicoline sodium salt

[中文别名 ]:

[英文别名 ]:

EINECS 251-689-1
Neuroton
CITICOLINE SODIUM SALT
MFCD00150508
Cytidine 5‘-diphosphocholine sodium salt hydrate
CDP-choline-Na
Citicoline Sodium
Cytidine 5′-diphosphocholine sodium salt
Citicoline sodium salt hydrate
Cidifos

胞磷胆碱钠生物活性

[ 描述 ]:

Cytidoline sodium salt 是一种合成细胞膜组分磷脂酰胆碱的中间体, 且发挥神经保护作用。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 神经疾病

[参考文献]

[1]. Davinelli S, et al. Cytoprotective Effects of Citicoline and Homotaurine against Glutamate and High Glucose Neurotoxicity in Primary Cultured Retinal Cells. Oxid Med Cell Longev. 2017;2017:2825703.

[2]. Karpova MN, et al. Increase of the seizure threshold in C57BL/6 mice after citicoline administration. Bull Exp Biol Med. 2015 Jan;158(3):315-7.

[相关活性小分子]

胞磷胆碱钠物理化学性质

[ 熔点 ]:
259-268°C (dec.)

[ 分子式 ]:
C₁₄H₂₆N₄NaO₁₁P₂

[ 分子量 ]:
511.31

[ PSA ]:
238.17000

[ 外观性状 ]:
白色固体

[ 储存条件 ]:
<0°C;存放于惰性气体之中;避免湿气 (吸湿),加热

胞磷胆碱钠MSDS

详细MSDS(安全技术说明书)

胞磷胆碱钠安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 安全声明 (欧洲) ]:
24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ 海关编码 ]:
2934999090

胞磷胆碱钠合成路线

详细合成路线

胞磷胆碱钠上下游产品

胞磷胆碱钠上游产品

胞磷胆碱钠下游产品

胞磷胆碱钠海关

[ 海关编码 ]: 2934999090

[ 中文概述 ]:
2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

胞磷胆碱钠文献

Gemcitabine diphosphate choline is a major metabolite linked to the Kennedy pathway in pancreatic cancer models in vivo.

Br. J. Cancer 111(2) , 318-25, (2014)

The modest benefits of gemcitabine (dFdC) therapy in patients with pancreatic ductal adenocarcinoma (PDAC) are well documented, with drug delivery and metabolic lability cited as important contributin...

A randomized dose-response trial of citicoline in acute ischemic stroke patients. Citicoline Stroke Study Group.

Neurology 49 , 671-678, (1997)

Citicoline (CDP-choline) is a key intermediary in the biosynthesis of phosphatidylcholine, an important component of the neural cell membrane. It has been shown to produce beneficial effects in both a...

Synergistic effects of citicoline and MK-801 in temporary experimental focal ischemia in rats.

Stroke 28 , 1060-1065, (1997)

Citicoline, a naturally occurring precursor of phosphatidylcholine, is neuroprotective and is currently being assessed in clinical trials. To evaluate potential synergistic neuroprotective effects of ...

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