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羟基积雪草苷

羟基积雪草苷用途

Madecassoside是一个从崩大碗中分离出来的五环三萜,有抗炎症。抗氧化和抗衰老的作用。

羟基积雪草苷名称

[ CAS 号 ]:
34540-22-2

[ 中文名 ]:
羟基积雪草苷

[ 英文名 ]:
Madecassoside

[中文别名 ]:

羟基积雪草甙

[英文别名 ]:

Asiaticoside A
MADESOIDE
RederMic
MADESOSIDE
Madecassoside

羟基积雪草苷生物活性

[ 描述 ]:

Madecassoside是一个从崩大碗中分离出来的五环三萜,有抗炎症。抗氧化和抗衰老的作用。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

天然产物 >> 萜类化合物和糖苷

研究领域 >> 其他

[参考文献]

[1]. Zexin Li et al. Madecassoside suppresses proliferation and invasiveness of HGF-induced human hepatocellular carcinoma cells via PKC-cMET-ERK1/2-COX-2-PGE2 pathway. Int Immunopharmacol. 2016 Apr;33:24-32.

[2]. Xia Y et al. Madecassoside ameliorates bleomycin-induced pulmonary fibrosis in mice through promoting the generation of hepatocyte growth factor via PPAR-γ in colon. Br J Pharmacol. 2016 Apr;173(7):1219-35

[3]. Su Z et al. Protective effects of madecassoside against Doxorubicin induced nephrotoxicity in vivo and in vitro. Sci Rep. 2015 Dec 14

[相关活性小分子]

羟基积雪草苷物理化学性质

[ 密度 ]:
1.5±0.1 g/cm3

[ 沸点 ]:
1043.6±65.0 °C at 760 mmHg

[ 分子式 ]:
C₄₈H₇₈O₂₀

[ 分子量 ]:
975.121

[ 闪点 ]:
295.8±27.8 °C

[ 精确质量 ]:
974.508667

[ PSA ]:
335.44000

[ LogP ]:
1.88

[ 外观性状 ]:
白色粉末

[ 蒸汽压 ]:
0.0±0.6 mmHg at 25°C

[ 折射率 ]:
1.637

[ 储存条件 ]:
2-8°C

[ 水溶解性 ]:
H2O: soluble1mg/mL, clear, colorless

羟基积雪草苷安全信息

[ 危害码 (欧洲) ]:
Xn

[ 安全声明 (欧洲) ]:
24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
YU9625000

羟基积雪草苷文献

Contact dermatitis due to Centella asiatica.

Contact Dermatitis 62(1) , 54-5, (2010)

Factors affecting the content of pentacyclic triterpenes in Centella asiatica raw materials.

Pharm. Biol. 50(12) , 1508-12, (2012)

Pentacyclic triterpenes, mainly, asiatic acid, madecassic acid, asiaticoside, and madecassoside are the active constituents of Centella asitica (L.) Urban. (Apiaceae). These compounds possess various ...

In vitroinhibitory effects of asiaticoside and madecassoside on human cytochrome P450

Toxicol. In Vitro 25(4) , 890-6, (2011)

The inhibitory effects and types of inhibition of asiaticoside and madecassoside on human CYPs were studied in vitro using recombinant human CYPs. The median inhibitory concentrations (IC 50) of asiat...

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