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5-甲基尿嘧啶

5-甲基尿嘧啶用途

5-Methylurapidil 是α1A-肾上腺素受体拮抗剂。5-Methylurapidil 可用于高血压、心力衰竭等心血管疾病的研究。

5-甲基尿嘧啶名称

[ CAS 号 ]:
34661-85-3

[ 中文名 ]:
5-甲基尿嘧啶

[ 英文名 ]:
5-Methylurapidil

[英文别名 ]:

5-甲基尿嘧啶生物活性

[ 描述 ]:

5-Methylurapidil 是α1A-肾上腺素受体拮抗剂。5-Methylurapidil 可用于高血压、心力衰竭等心血管疾病的研究。

[ 相关类别 ]:

研究领域 >> 心血管疾病

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 肾上腺素能受体

[参考文献]

[1]. Arce C, et al. Activation of α1A -adrenoceptors desensitizes the rat aorta response to phenylephrine through a neuronal NOS pathway, a mechanism lost with ageing. Br J Pharmacol. 2017 Jul;174(13):2015-2030.

5-甲基尿嘧啶物理化学性质

[ 分子式 ]:
C₂₁H₃₂ClN₅O₃

[ 分子量 ]:
437.96300

[ 精确质量 ]:
437.21900

[ PSA ]:
71.74000

[ LogP ]:
1.90310

5-甲基尿嘧啶安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

5-甲基尿嘧啶文献

Cell membrane chromatography competitive binding analysis for characterization of α1A adrenoreceptor binding interactions.

Anal. Bioanal. Chem 400(10) , 3625-33, (2011)

A new high α(1A) adrenoreceptor (α(1A)AR) expression cell membrane chromatography (CMC) method was developed for characterization of α(1A)AR binding interactions. HEK293 α(1A) cell line, which express...

Influence of high dietary sodium intake on the functional subtypes of alpha-adrenoceptors in the renal cortical vasculature of Wistar-Kyoto rats.

Auton. Autacoid Pharmacol. 29(1-2) , 25-31, (2009)

1 Increased renal vascular resistance is one renal functional abnormality that contributes to hypertension, and alpha(1)-adrenoceptors play a pivotal role in modulating this renal vascular resistance....

Alpha-1A adrenergic receptor activation increases inhibitory tone in CA1 hippocampus.

Epilepsy Res. 84(2-3) , 97-109, (2009)

The endogenous catecholamine norepinephrine (NE) exhibits anti-epileptic properties, however it is not well understood which adrenergic receptor (AR) mediates this effect. The aim of this study was to...

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