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1-(2-吡啶基)哌嗪

1-(2-吡啶基)哌嗪用途

1-(2-吡啶基)哌嗪是一种生物化学试剂,可作为生物材料或有机化合物用于生命科学相关研究。

1-(2-吡啶基)哌嗪名称

[ CAS 号 ]:
34803-66-2

[ 中文名 ]:
1-(2-吡啶基)哌嗪

[ 英文名 ]:
1-(2-Pyridinyl)piperazine

[中文别名 ]:

[英文别名 ]:

2-(1-Piperazinyl)pyridine
1-(pyridin-2-yl)piperazine
2-Piperazinopyridine
1-(2-Pyridinyl)piperazine
Piperazine, 1-(2-pyridinyl)-
MFCD00006216
EINECS 252-220-3
2-pyridylpiperazine
1-(2-Pyridyl)Piperazine

1-(2-吡啶基)哌嗪生物活性

[ 描述 ]:

1-(2-吡啶基)哌嗪是一种生物化学试剂,可作为生物材料或有机化合物用于生命科学相关研究。

[ 相关类别 ]:

研究领域 >> 其他

[体外研究]

1-(2-吡啶基)哌嗪是一种选择性的 α2-肾上腺素能受体拮抗剂。它显示出同情活动。它也是氮杂培隆的代谢产物。

1-(2-吡啶基)哌嗪物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
314.4±22.0 °C at 760 mmHg

[ 熔点 ]:
92-94

[ 分子式 ]:
C₉H₁₃N₃

[ 分子量 ]:
163.22

[ 闪点 ]:
143.9±22.3 °C

[ 精确质量 ]:
163.110947

[ PSA ]:
28.16000

[ LogP ]:
0.19

[ 外观性状 ]:
透明无色至淡黄色液体

[ 蒸汽压 ]:
0.0±0.7 mmHg at 25°C

[ 折射率 ]:
1.547

[ 储存条件 ]:
Flammables area

[ 水溶解性 ]:
>500 g/L (20 ºC)

1-(2-吡啶基)哌嗪MSDS

1-(2-吡啶基)哌嗪安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
Xi:Irritant;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36

[ 危险品运输编码 ]:
2735

[ WGK德国 ]:
3

[ 包装等级 ]:
II

[ 危险类别 ]:
8

[ 海关编码 ]:
2933990090

1-(2-吡啶基)哌嗪合成路线

1-(2-吡啶基)哌嗪上下游产品

1-(2-吡啶基)哌嗪上游产品

1-(2-吡啶基)哌嗪下游产品

1-(2-吡啶基)哌嗪海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

1-(2-吡啶基)哌嗪文献

Pharmacological evidence for the involvement of 1-(2-pyridinyl)-piperazine (1-PmP) in the interaction of buspirone or gepirone with noradrenergic systems.

Eur. J. Pharmacol. 134(1) , 113-6, (1987)

We investigated in mice the effects of one of the principal metabolites of buspirone and gepirone, 1-(2-pyridinyl)-piperazine (1-PmP), on hypothermia and reduced locomotion induced by clonidine (0.25 ...

6-Hydroxybuspirone is a major active metabolite of buspirone: assessment of pharmacokinetics and 5-hydroxytryptamine1A receptor occupancy in rats.

Drug Metab. Dispos. 35(8) , 1387-92, (2007)

The pharmacokinetics and in vivo potency of 6-hydroxybuspirone (6-OH-buspirone), a major metabolite of buspirone, were investigated. The plasma clearance (47.3 +/- 3.5 ml/min/kg), volume of distributi...

New lithocholic and chenodeoxycholic piperazinylcarboxamides with antiproliferative and pro-apoptotic effects on human cancer cell lines.

Bioorg. Med. Chem. 16 , 8737-44, (2008)

Six new synthetic bile acid derivatives were synthesized and tested in vitro against various human cancer cells (glioblastoma multiforme (GBM), multiple myeloma (KMS-11), and colonic carcinoma (HCT-11...

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