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双氢卡马西平

双氢卡马西平用途

10,11-二氢卡马西平是奥卡西平的活性代谢产物。10,11-二氢卡马西平也是一种中间体。奥卡西平迅速且几乎完全转化为10,11-二氢卡马西平,可能具有抗惊厥功效[1]。

双氢卡马西平名称

[ CAS 号 ]:
3564-73-6

[ 中文名 ]:
双氢卡马西平

[ 英文名 ]:
10,11-Dihydrocarbamazepine

[中文别名 ]:

[英文别名 ]:

10,11-dihydro-5-carboxamido-5H-dibenz<b,f>azepine
10,11-Dihydro-5-carbamoyl-5H-dibenz<b,f>azepin
10,11-Dihydro-5-carbamoyl-5H-dibenz<b,f>azepine
GP 26-301
10,11-DIHYDROCARBAMAZEPINE
EINECS 222-649-0
10,11-Dihydro-5H-dibenz[b,f]azepine-5-carboxamide
MFCD00005072
10,11-Dihydro-5H-dibenz(b,f)azepine-5-carboxamide
10,11-Dihydro-5H-dibenzo[b,f]azepine-5-carboxamide

双氢卡马西平生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 神经疾病

[体外研究]

奥卡西平在肝脏代谢为其活性代谢物10,11-二氢卡马西平。奥卡西平是一种抗癫痫药物(AED),用于作为单一疗法或辅助疗法治疗部分性癫痫[1]。10,11-二氢卡马西平可用作通过液相色谱法(LC)测定药物制剂中10,11-二氢卡马西平的参考标准[1]。

[参考文献]

[1]. Courtney Hunek, et al. Measurement of 10,11-dihydro-10-hydroxy-carbamazepine in serum and plasma by high-performance liquid chromatography. Clin Chem Lab Med. 2008;46(10):1429-33.

双氢卡马西平物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
394.5±52.0 °C at 760 mmHg

[ 熔点 ]:
205-210ºC

[ 分子式 ]:
C₁₅H₁₄N₂O

[ 分子量 ]:
238.28

[ 闪点 ]:
192.4±30.7 °C

[ 精确质量 ]:
238.110611

[ PSA ]:
46.33000

[ LogP ]:
2.60

[ 蒸汽压 ]:
0.0±0.9 mmHg at 25°C

[ 折射率 ]:
1.645

[ 储存条件 ]:
Refrigerator

[ 水溶解性 ]:
dichloromethane: soluble2.5%, clear, colorless | Soluble in dichloromethane. Insoluble in water.

双氢卡马西平MSDS

双氢卡马西平毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: HN8300000

CHEMICAL NAME :: 5H-Dibenz(b,f)azepine-5-carboxamide, 10,11-dihydro-

CAS REGISTRY NUMBER :: 3564-73-6

BEILSTEIN REFERENCE NO. :: 0196969

LAST UPDATED :: 199712

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C15-H14-N2-O

MOLECULAR WEIGHT :: 238.31

WISWESSER LINE NOTATION :: T C676 BN&T&J BVZ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 750 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 7,88,1964

双氢卡马西平安全信息

[ 符号 ]:

GHS07, GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H302-H317-H334

[ 警示性声明 ]:
P261-P280-P342 + P311

[ 危害码 (欧洲) ]:
Xn

[ 风险声明 (欧洲) ]:
22-42/43

[ 安全声明 (欧洲) ]:
S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
HN8300000

[ 海关编码 ]:
2933990090

双氢卡马西平合成路线

双氢卡马西平海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

双氢卡马西平文献

Structure-activity relationship and site of binding of polyamine derivatives at the nicotinic acetylcholine receptor.

Eur. J. Biochem. 267(1) , 110-20, (2000)

Several wasp venoms contain philanthotoxins (PhTXs), natural polyamine amides, which act as noncompetitive inhibitors (NCIs) on the nicotinic acetylcholine receptor (nAChR). Effects of varying the str...

Liquid chromatographic methods for assay of carbamazepine, 10,11-dihydrocarbamazepine, and related compounds in carbamazepine drug substance and tablets.

J. Assoc. Off. Anal. Chem. 70(5) , 836-40, (1987)

Liquid chromatographic (LC) methods have been developed for the determination of carbamazepine, the impurity 10,11-dihydrocarbamazepine, and related compounds in carbamazepine drug substance and table...

An orthorhombic polymorph of 10,11-dihydrocarbamazepine.

Acta Crystallogr. C 62(Pt 5) , o240-2, (2006)

The title compound (systematic name: 10,11-dihydro-5H-dibenz[b,f]azepine-5-carboxamide), C15H14N2O, is shown to crystallize as an orthorhombic polymorph to complement the known monoclinic form. The mo...

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