2-Deoxy-D-glucose 6-phosphate

2-Deoxy-D-glucose 6-phosphate用途

2-脱氧-D-葡萄糖6-磷酸是2-脱氧-D-葡萄糖(2-DG)的中间体[1]。2-脱氧-D-葡萄糖被并入糖原[2]。

2-Deoxy-D-glucose 6-phosphate名称

[ CAS 号 ]:
3573-50-0

[ 英文名 ]:
2-Deoxy-D-glucose-6-phosphate

[英文别名 ]:

2-Deoxy-D-glucose-6-phosphate
D-lyxo-2-Desoxy-hexose-6-phosphat
2-deoxyglucose-6-phosphate
O6-phosphono-D-lyxo-2-deoxy-hexose
D-lyxo-3,4,5-Trihydroxy-6-phosphonooxy-hexanal
O6-Phosphono-D-lyxo-2-desoxy-hexose

2-Deoxy-D-glucose 6-phosphate生物活性

[ 描述 ]:

2-脱氧-D-葡萄糖6-磷酸是2-脱氧-D-葡萄糖(2-DG)的中间体[1]。2-脱氧-D-葡萄糖被并入糖原[2]。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 代谢疾病

[体外研究]

作为D-葡萄糖模拟物,2-脱氧-D-葡萄糖(2-DG)由于2-脱氧-D-葡萄糖-6-磷酸(2-DG6P)的形成和细胞内积累而抑制糖酵解,抑制己糖激酶和葡萄糖-6-磷酸异构酶的功能,并诱导细胞死亡[3]。使用31P核磁共振波谱检测2-脱氧葡萄糖-6-磷酸(2-DG6P)的积累,用于评估离体灌注心脏胰岛素刺激前后的葡萄糖摄取[4]。

[参考文献]

[1]. Kuo SC, et al. Inhibition by 2-deoxy-D-glucose of synthesis of glycoprotein enzymes by protoplasts of Saccharomyces: relation to inhibition of sugar uptake and metabolism. J Bacteriol. 1972;111(2):419-429.

[2]. Doenst T, et al. Complexities underlying the quantitative determination of myocardial glucose uptake with 2-deoxyglucose. J Mol Cell Cardiol. 1998;30(8):1595-1604.

[3]. Pajak B, et al. 2-Deoxy-d-Glucose and Its Analogs: From Diagnostic to Therapeutic Agents. Int J Mol Sci. 2019;21(1):234. Published 2019 Dec 29.

[4]. Paternostro G, et al. Decreased GLUT-4 mRNA content and insulin-sensitive deoxyglucose uptake show insulin resistance in the hypertensive rat heart. Cardiovasc Res. 1995;30(2):205-211.

2-Deoxy-D-glucose 6-phosphate物理化学性质

[ 密度 ]:
1.694g/cm3

[ 沸点 ]:
606.9ºC at 760mmHg

[ 分子式 ]:
C₆H₁₃O₈P

[ 分子量 ]:
244.14

[ 闪点 ]:
320.8ºC

[ 精确质量 ]:
244.03500

[ PSA ]:
146.49000

[ 折射率 ]:
1.574

2-Deoxy-D-glucose 6-phosphate

2-Deoxy-D-glucose 6-phosphate用途

2-Deoxy-D-glucose 6-phosphate名称

2-Deoxy-D-glucose 6-phosphate生物活性

2-Deoxy-D-glucose 6-phosphate物理化学性质

2-Deoxy-D-glucose 6-phosphate合成路线

详细合成路线

2-Deoxy-D-glucose 6-phosphate上下游产品

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