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斑鸠霉素

斑鸠霉素用途

Ikarugamycin 是一种抗生素,也是一种网格蛋白介导的内吞 (CME) 抑制剂。

斑鸠霉素名称

[ CAS 号 ]:
36531-78-9

[ 中文名 ]:
斑鸠霉素

[ 英文名 ]:
Ikarugamycin

[英文别名 ]:

Ikarugamycin
tu-6239 c3

斑鸠霉素生物活性

[ 描述 ]:

Ikarugamycin 是一种抗生素,也是一种网格蛋白介导的内吞 (CME) 抑制剂。

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

[ 靶点 ]

Clathrin-mediated endocytosis[1]

[体外研究]

Ikarugamycin在H1299细胞中的IC50为2.7μM[1]。

[参考文献]

[1]. Elkin SR, et al. Ikarugamycin: A Natural Product Inhibitor of Clathrin-Mediated Endocytosis. Traffic. 2016 Oct;17(10):1139-49.

斑鸠霉素物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
741.9±60.0 °C at 760 mmHg

[ 分子式 ]:
C₂₉H₃₈N₂O₄

[ 分子量 ]:
478.62

[ 闪点 ]:
402.5±32.9 °C

[ 精确质量 ]:
478.283173

[ PSA ]:
95.50000

[ LogP ]:
5.05

[ 蒸汽压 ]:
0.0±5.6 mmHg at 25°C

[ 折射率 ]:
1.604

[ 储存条件 ]:
-20°C

斑鸠霉素毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NI0625500

CHEMICAL NAME :: Ikarugamycin

CAS REGISTRY NUMBER :: 36531-78-9

LAST UPDATED :: 199206

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C29-H38-N2-O4

MOLECULAR WEIGHT :: 478.69

WISWESSER LINE NOTATION :: T I5 H6 F5-17-5 A CV UVM D&MV DU NU SU C&HTTTT&J AQ L2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 25,271,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 6 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 25,271,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >250 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 25,271,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 25,271,1972

斑鸠霉素安全信息

[ 符号 ]:

GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H301

[ 警示性声明 ]:
P301 + P310

[ 危害码 (欧洲) ]:
T

[ 危险品运输编码 ]:
UN 2811 6.1 / PGIII

斑鸠霉素合成路线

详细合成路线

斑鸠霉素上下游产品

斑鸠霉素上游产品

斑鸠霉素下游产品

斑鸠霉素文献

Pathogen- and Host-Directed Antileishmanial Effects Mediated by Polyhexanide (PHMB).

PLoS Negl. Trop. Dis. 9 , e0004041, (2015)

Cutaneous leishmaniasis (CL) is a neglected tropical disease caused by protozoan parasites of the genus Leishmania. CL causes enormous suffering in many countries worldwide. There is no licensed vacci...

Clathrin-dependent and independent endocytic pathways in tobacco protoplasts revealed by labelling with charged nanogold.

J. Exp. Bot. 59(11) , 3051-68, (2008)

Positively charged nanogold was used as a probe to trace the internalization of plasma membrane (PM) domains carrying negatively charged residues at an ultrastructural level. The probe revealed distin...

Distinct endocytic pathways identified in tobacco pollen tubes using charged nanogold.

J. Cell Sci. 120(Pt 21) , 3804-19, (2007)

In an attempt to dissect endocytosis in Nicotiana tabacum L. pollen tubes, two different probes--positively or negatively charged nanogold--were employed. The destiny of internalized plasma membrane d...

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