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高牛磺酸

高牛磺酸用途

Tramiprosate是一个小的,能够口服的化合物,可以结合可溶性Aβ,减少淀粉样蛋白聚合和随后的沉积。

高牛磺酸名称

[ CAS 号 ]:
3687-18-1

[ 中文名 ]:
3-氨基-1-丙磺酸

[ 英文名 ]:
Tramiprosate

[中文别名 ]:

[英文别名 ]:

1-Propanesulfonic acid, 3-amino-
tramiprosate
Homotaurine
3-aminopropane-1-sulfonic acid
Alzhemed
3-Aminopropane sulfonic acid
3-Amino-1-propanesulfonic acid
3-aminopropane-1-sulphonic acid
3-Amino-propane-1-sulfonic acid
3-APS

高牛磺酸生物活性

[ 描述 ]:

Tramiprosate是一个小的,能够口服的化合物,可以结合可溶性Aβ,减少淀粉样蛋白聚合和随后的沉积。

[ 相关类别 ]:

信号通路 >> 神经信号通路 >> β淀粉样蛋白

研究领域 >> 癌症

[参考文献]

[1]. Wu S et al. Tramiprosate protects neurons against ischemic stroke by disrupting the interaction between PSD95 and nNOS. Neuropharmacology. 2014 Aug;83:107-17.

[2]. Aisen PS et al. Tramiprosate in mild-to-moderate Alzheimer's disease - a randomized, double-blind, placebo-controlled, multi-centre study (the Alphase Study). Arch Med Sci. 2011 Feb;7(1):102-11.

[相关活性小分子]

高牛磺酸物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 熔点 ]:
293 °C (dec.)(lit.)

[ 分子式 ]:
C₃H₉NO₃S

[ 分子量 ]:
139.173

[ 精确质量 ]:
139.030319

[ PSA ]:
88.77000

[ LogP ]:
-2.25

[ 外观性状 ]:
白色晶体或结晶粉末

[ 折射率 ]:
1.508

[ 储存条件 ]:
Store at 0-5°C

高牛磺酸MSDS

高牛磺酸安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi:Irritant;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
1

[ 海关编码 ]:
2921199090

高牛磺酸合成路线

高牛磺酸上下游产品

高牛磺酸上游产品

高牛磺酸下游产品

高牛磺酸海关

[ 海关编码 ]: 2921199090

[ 中文概述 ]:
2921199090 其他无环单胺及其衍生物及其盐。监管条件:无。增值税率:17.0%。退税率:9.0%。最惠国关税:6.5%。普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2921199090 other acyclic monoamines and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

高牛磺酸文献

Altering in vivo macrophage responses with modified polymer properties.

Biomaterials 56 , 187-97, (2015)

Macrophage reprogramming has long been the focus of research in disease therapeutics and biomaterial implantation. With different chemical and physical properties of materials playing a role in macrop...

Phospho-iTRAQ: assessing isobaric labels for the large-scale study of phosphopeptide stoichiometry.

J. Proteome Res. 14(2) , 839-49, (2015)

The ability to distinguish between phosphopeptides of high and low stoichiometry is essential to discover the true extent of protein phosphorylation. We here extend the strategy whereby a peptide samp...

Effect of bore fluid composition on microstructure and performance of a microporous hollow fibre membrane as a cation-exchange substrate.

J. Chromatogr. A. 1394 , 148-53, (2015)

Micro-capillary film (MCF) membranes are effective platforms for bioseparations and viable alternatives to established packed bed and membrane substrates at the analytical and preparative chromatograp...

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