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(-)-N⁶-(2-苯基异丙基)腺苷

(-)-N⁶-(2-苯基异丙基)腺苷用途

(-)-N6苯异丙基腺苷(D-苯基异丙基腺苷)是一种腺苷受体激动剂。(-)-N6苯基异丙基腺苷抑制K+诱发的Ca2+摄取,IC50值为0.5µM[1]。

(-)-N⁶-(2-苯基异丙基)腺苷名称

[ CAS 号 ]:
38594-96-6

[ 中文名 ]:
R-(-)-N6-(2-苯基异丙基)腺苷酸

[ 英文名 ]:
(R)?-?PIA

[中文别名 ]:

N6-(1-苯基-2-丙醇)腺苷

[英文别名 ]:

EINECS 254-028-5
(−)-N6-(2-Phenylisopropyl)adenosine
MFCD00069194

(-)-N⁶-(2-苯基异丙基)腺苷生物活性

[ 描述 ]:

(-)-N6苯异丙基腺苷(D-苯基异丙基腺苷)是一种腺苷受体激动剂。(-)-N6苯基异丙基腺苷抑制K+诱发的Ca2+摄取,IC50值为0.5µM[1]。

[ 相关类别 ]:

研究领域 >> 神经疾病

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 腺苷受体

[参考文献]

[1]. Wu PH, et al. Adenosine receptor agonists inhibit K+-evoked Ca2+ uptake by rat brain cortical synaptosomes. J Neurochem. 1982 Sep;39(3):700-8.

(-)-N⁶-(2-苯基异丙基)腺苷物理化学性质

[ 密度 ]:
1.506g/cm3

[ 沸点 ]:
675.716ºC at 760 mmHg

[ 分子式 ]:
C₁₉H₂₃N₅O₄

[ 分子量 ]:
385.42

[ 闪点 ]:
362.46ºC

[ 精确质量 ]:
385.17500

[ PSA ]:
125.55000

[ LogP ]:
0.55390

[ 折射率 ]:
1.712

[ 储存条件 ]:
2-8°C，密封，干燥

(-)-N⁶-(2-苯基异丙基)腺苷MSDS

详细MSDS(安全技术说明书)

(-)-N⁶-(2-苯基异丙基)腺苷毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AU7404930

CHEMICAL NAME :: Adenosine, N-(1-methyl-2-phenylethyl)-, (R)-

CAS REGISTRY NUMBER :: 38594-96-6

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C19-H23-N5-O4

MOLECULAR WEIGHT :: 385.47

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 770 ug/kg

SEX/DURATION :: female 11-12 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetal death

REFERENCE :: TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 25(2),35A,1982

(-)-N⁶-(2-苯基异丙基)腺苷安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

(-)-N⁶-(2-苯基异丙基)腺苷文献

Characterization of the A2 adenosine receptor labeled by [3H]NECA in rat striatal membranes.

Mol. Pharmacol. 29 , 331, (1986)

[3H]NECA (1-(6-amino-9H-purin-9-yl)-1-deoxy-N-ethyl-beta-D-ribofuronamide) is known to bind to both the A1 and A2 subtypes of adenosine receptor in rat striatal membranes. In order to study the putati...

Negative crosstalk between M1 and M2 muscarinic autoreceptors involves endogenous adenosine activating A1 receptors at the rat motor endplate.

Neurosci. Lett. 459 , 127-131, (2009)

At the rat motor nerve terminals, activation of muscarinic M(1) receptors negatively modulates the activity of inhibitory muscarinic M(2) receptors. The present work was designed to investigate if the...

Rapid stimulation of presynaptic serotonin transport by A(3) adenosine receptors.

J. Pharmacol. Exp. Ther. 322(1) , 332-40, (2007)

The inactivation of synaptic serotonin (5-hydroxytryptamine, 5-HT) is largely established through the actions of the presynaptic, antidepressant-sensitive 5-HT transporter (SERT, SLC6A4). Recent studi...

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