4-过氧化氢异环磷酰胺

4-过氧化氢异环磷酰胺用途

4-过氧化氢一磷酰胺是一种可以穿透血脑屏障(BBB)的抗癌剂[1]。

4-过氧化氢异环磷酰胺名称

[ CAS 号 ]:
39800-28-7

[ 中文名 ]:
4-过氧化氢异环磷酰胺

[ 英文名 ]:
2H-1,3,2-Oxazaphosphorin-2-amine,N,3-bis(2-chloroethyl)tetrahydro-4-hydroperoxy-, 2-oxide

[英文别名 ]:

4-过氧化氢异环磷酰胺生物活性

[ 描述 ]:

4-过氧化氢一磷酰胺是一种可以穿透血脑屏障(BBB)的抗癌剂[1]。

[ 相关类别 ]:

研究领域 >> 癌症

[参考文献]

[1]. Ishimoto TM, et al. Allelic variants of the human glutathione S-transferase P1 gene confer differential cytoprotection against anticancer agents in Escherichia coli. Pharmacogenetics. 2002 Oct;12(7):543-53.  

4-过氧化氢异环磷酰胺物理化学性质

[ 密度 ]:
1.46g/cm3

[ 沸点 ]:
419.9ºC at 760mmHg

[ 分子式 ]:
C7H15Cl2N2O4P

[ 分子量 ]:
293.08

[ 闪点 ]:
207.8ºC

[ 精确质量 ]:
292.01500

[ PSA ]:
80.84000

[ LogP ]:
2.02850

[ 折射率 ]:
1.525

4-过氧化氢异环磷酰胺毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :
MX2435000
CHEMICAL NAME :
Hydroperoxide, 3-(2-chloroethyl)-2-((2-chloroethyl)amino)tetrahydro- 2H-1,3,2-oxazaphospho rin- 4-yl-, P-oxide
CAS REGISTRY NUMBER :
39800-28-7
LAST UPDATED :
199310
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C7-H15-Cl2-N2-O4-P
MOLECULAR WEIGHT :
293.11

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
180 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CTRRDO Cancer Treatment Reports. (Washington, DC) V.60-71, 1976-87. For publisher information, see JNCIEQ. Volume(issue)/page/year: 60,361,1976
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
220 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CTRRDO Cancer Treatment Reports. (Washington, DC) V.60-71, 1976-87. For publisher information, see JNCIEQ. Volume(issue)/page/year: 60,361,1976
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
230 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CTRRDO Cancer Treatment Reports. (Washington, DC) V.60-71, 1976-87. For publisher information, see JNCIEQ. Volume(issue)/page/year: 60,361,1976
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
230 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CTRRDO Cancer Treatment Reports. (Washington, DC) V.60-71, 1976-87. For publisher information, see JNCIEQ. Volume(issue)/page/year: 60,361,1976

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