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5-硝基-8-羟基喹啉

5-硝基-8-羟基喹啉用途

Nitroxoline是一种抗生素, 有效防治生物膜感染, Nitroxoline通过从生物膜基质螯合Fe2+和Zn2+离子而发挥作用。

5-硝基-8-羟基喹啉名称

[ CAS 号 ]:
4008-48-4

[ 中文名 ]:
5-硝基-8-羟基喹啉

[ 英文名 ]:
Nitroxoline

[中文别名 ]:

[英文别名 ]:

5-nitryl-8-hydroxyquinoline
EINECS 223-662-4
Nitroxolina
5-Nitro-8-quinolinol
Notroxoline
Enterocol
5-Nitro-8-hydroxyquinoline
MFCD00006791
Nitroxolinum
8-Quinolinol, 5-nitro-

5-硝基-8-羟基喹啉生物活性

[ 描述 ]:

Nitroxoline是一种抗生素, 有效防治生物膜感染, Nitroxoline通过从生物膜基质螯合Fe2+和Zn2+离子而发挥作用。

[ 相关类别 ]:

信号通路 >> 自噬 >> 自噬

信号通路 >> 抗感染 >> 细菌

研究领域 >> 感染

[相关活性小分子]

5-硝基-8-羟基喹啉物理化学性质

[ 密度 ]:
1.5±0.1 g/cm3

[ 沸点 ]:
419.0±35.0 °C at 760 mmHg

[ 熔点 ]:
181-183ºC

[ 分子式 ]:
C₉H₆N₂O₃

[ 分子量 ]:
190.156

[ 闪点 ]:
207.2±25.9 °C

[ 精确质量 ]:
190.037842

[ PSA ]:
78.94000

[ LogP ]:
2.00

[ 外观性状 ]:
赭色-黄色至褐色结晶粉末

[ 蒸汽压 ]:
0.0±1.0 mmHg at 25°C

[ 折射率 ]:
1.728

[ 储存条件 ]:
存放于惰性气体之中;避免光,空气

[ 水溶解性 ]:
alcohol: very slightly soluble

5-硝基-8-羟基喹啉MSDS

5-硝基-8-羟基喹啉毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: VC8225000

CHEMICAL NAME :: 8-Quinolinol, 5-nitro-

CAS REGISTRY NUMBER :: 4008-48-4

BEILSTEIN REFERENCE NO. :: 0166146

LAST UPDATED :: 199712

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C9-H6-N2-O3

MOLECULAR WEIGHT :: 190.17

WISWESSER LINE NOTATION :: T66 BNJ GNW JQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 510 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

REFERENCE :: ATXKA8 Archiv fuer Toxikologie. (Berlin, Fed. Rep. Ger.) V.15-31, 1954-74. For publisher information, see ARTODN. Volume(issue)/page/year: 20,313,1965

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 104 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

REFERENCE :: ATXKA8 Archiv fuer Toxikologie. (Berlin, Fed. Rep. Ger.) V.15-31, 1954-74. For publisher information, see ARTODN. Volume(issue)/page/year: 20,313,1965

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 8300 ug/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

REFERENCE :: ATXKA8 Archiv fuer Toxikologie. (Berlin, Fed. Rep. Ger.) V.15-31, 1954-74. For publisher information, see ARTODN. Volume(issue)/page/year: 20,313,1965 ** TUMORIGENIC DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 13 gm/kg/52W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Blood - lymphoma, including Hodgkin's disease

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 8,343,1966

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 26 gm/kg/52W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Blood - lymphoma, including Hodgkin's disease

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 8,343,1966

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 52 gm/kg/52W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Blood - lymphoma, including Hodgkin's disease

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 8,343,1966

5-硝基-8-羟基喹啉安全信息

[ 符号 ]:

GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H301 + H311 + H331-H315-H319-H335

[ 警示性声明 ]:
P261-P280-P301 + P310-P305 + P351 + P338-P311

[ 个人防护装备 ]:
Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
T:Toxic;

[ 风险声明 (欧洲) ]:
R22/24/25;R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36-S45

[ 危险品运输编码 ]:
UN 2811

[ WGK德国 ]:
3

[ RTECS号 ]:
VC8225000

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1

[ 海关编码 ]:
2933499090

5-硝基-8-羟基喹啉合成路线

5-硝基-8-羟基喹啉上下游产品

5-硝基-8-羟基喹啉上游产品

5-硝基-8-羟基喹啉下游产品

5-硝基-8-羟基喹啉海关

[ 海关编码 ]: 2933499090

[ 中文概述 ]:
2933499090. 其他含喹琳或异喹啉环系的化合物〔但未进一步稠合的〕. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

5-硝基-8-羟基喹啉文献

Development of new cathepsin B inhibitors: combining bioisosteric replacements and structure-based design to explore the structure-activity relationships of nitroxoline derivatives.

J. Med. Chem. 56(2) , 521-33, (2013)

Human cathepsin B has many house-keeping functions, such as protein turnover in lysosomes. However, dysregulation of its activity is associated with numerous diseases, including cancers. We present he...

Redox-based inactivation of cysteine cathepsins by compounds containing the 4-aminophenol moiety.

PLoS ONE 6(11) , e27197, (2011)

Redox cycling compounds have been reported to cause false positive inhibition of proteases in drug discovery studies. This kind of false positives can lead to unusually high hit rates in high-throughp...

Experimental and theoretical quantum chemical investigations of 8-hydroxy-5-nitroquinoline.

Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 96 , 506-16, (2012)

The FT-IR and FT-Raman spectra of 8-hydroxy-5-nitroquinoline have been recorded in the regions 4000-400 and 4000-100 cm(-1), respectively. The spectra were interpreted in terms of fundamentals modes, ...

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