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丁二酸二酰肼

丁二酸二酰肼名称

[ CAS 号 ]:
4146-43-4

[ 中文名 ]:
丁二酸二酰肼

[ 英文名 ]:
Succinohydrazide

[中文别名 ]:

[英文别名 ]:

succinic acid hydrazide
Succinic acid,dihydrazide
Succinic hydrazide
Succinic Dihydrazide
Butanedioic acid, dihydrazide
Succinyl dihydrazide
MFCD00007613
Succinohydrazide
Butanedioic acid,dihydrazide
Succinhydrazide

丁二酸二酰肼物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
540.2±33.0 °C at 760 mmHg

[ 熔点 ]:
170-171 °C(lit.)

[ 分子式 ]:
C₄H₁₀N₄O₂

[ 分子量 ]:
146.148

[ 闪点 ]:
280.5±25.4 °C

[ 精确质量 ]:
146.080383

[ PSA ]:
110.24000

[ LogP ]:
-3.18

[ 外观性状 ]:
固体;White to Almost white powder to crystal

[ 蒸汽压 ]:
0.0±1.4 mmHg at 25°C

[ 折射率 ]:
1.526

[ 储存条件 ]:
存放于惰性气体之中;避免空气

[ 水溶解性 ]:
水溶性：可溶；水溶解度：340 g/l 25 °C

丁二酸二酰肼MSDS

丁二酸二酰肼毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: WM7500000

CHEMICAL NAME :: Succinic acid, dihydrazide

CAS REGISTRY NUMBER :: 4146-43-4

BEILSTEIN REFERENCE NO. :: 1775110

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C4-H10-N4-O2

MOLECULAR WEIGHT :: 146.18

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JMPCAS Journal of Medicinal and Pharmaceutical Chemistry. (Washington, DC) V.1-5, 1959-62. For publisher information, see JMCMAR. Volume(issue)/page/year: 4,259,1961

丁二酸二酰肼安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn: Harmful;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
WM7500000

[ 海关编码 ]:
2928000090

丁二酸二酰肼合成路线

丁二酸二酰肼上下游产品

丁二酸二酰肼上游产品

丁二酸二酰肼下游产品

丁二酸二酰肼海关

[ 海关编码 ]: 2928000090

[ 中文概述 ]:
2928000090 其他肼（联氨）及胲（羟胺）的有机衍生物。监管条件:无。增值税率:17.0%。退税率:9.0%。最惠国关税:6.5%。普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2928000090 other organic derivatives of hydrazine or of hydroxylamine VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%

丁二酸二酰肼文献

Efficient Delivery of DOX to Nuclei of Hepatic Carcinoma Cells in the Subcutaneous Tumor Model Using pH-Sensitive Pullulan-DOX Conjugates.

ACS Appl. Mater. Interfaces 7 , 15855-65, (2015)

A series of pullulan-doxorubicin conjugates (Pu-DOXs) were investigated for effectively delivering DOX to nuclei of hepatic carcinoma cells in subcutaneous tumor model. These Pu-DOXs were prepared by ...

Pharmacokinetics and biodistribution of 99mTc N-MPO in healthy human volunteers.

Clin. Nucl. Med. 39(1) , e14-9, (2013)

Tc N-MPO ([Tc N(MPO)(PNP5)]: HMPO = 2-mercaptopyridine N-oxide, and PNP5 = N-ethoxyethyl-N,N-bis[2-(bis(3-methoxypropyl)phosphino)ethyl]amine) is a new Tc radiotracer useful for myocardial perfusion i...

Biodistribution of nanostructured lipid carriers: a tomographic study.

Eur. J. Pharm. Biopharm. 89 , 145-56, (2015)

This study describes the preparation, characterization, and biodistribution of radiolabelled nanostructured lipid carriers (NLCs) especially designed for in vivo tomographic study. A preliminary formu...

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