尼泊金异丁酯

尼泊金异丁酯用途

Isobutylparaben (Isobutyl 4-hydroxybenzoate) 是组成型雄烷受体 (CAR) 激活剂。Isobutylparaben 具有广谱抗菌 (antimicrobial) 活性,并广泛用于个人护理产品和化妆品中。

尼泊金异丁酯名称

[ CAS 号 ]:
4247-02-3

[ 中文名 ]:
4-羟基苯甲酸异丁酯

[ 英文名 ]:
Isobutylparaben

[中文别名 ]:

[英文别名 ]:

Benzoic acid, 4-hydroxy-, 2-methylpropyl ester
EINECS 224-208-8
Isobutyl 4-hydroxybenzoate
Isobutyl paraben
2-methylpropyl 4-hydroxybenzoate
MFCD00020167

尼泊金异丁酯生物活性

[ 描述 ]:

Isobutylparaben (Isobutyl 4-hydroxybenzoate) 是组成型雄烷受体 (CAR) 激活剂。Isobutylparaben 具有广谱抗菌 (antimicrobial) 活性,并广泛用于个人护理产品和化妆品中。

[ 相关类别 ]:

研究领域 >> 炎症/免疫

信号通路 >> 抗感染 >> 细菌

[参考文献]

[1]. Chieri Fujino, et al. Comparative Study of the Effect of 17 Parabens on PXR-, CAR- And PPARα-mediated Transcriptional Activation. Food Chem Toxicol. 2019 Nov;133:110792.

[2]. Fei Meng, et al. Isobutylparaben Negatively Affects Porcine Oocyte Maturation Through Increasing Oxidative Stress and Cytoskeletal Abnormalities. Environ Mol Mutagen. 2020 Apr;61(4):433-444.

尼泊金异丁酯物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
302.3±15.0 °C at 760 mmHg

[ 熔点 ]:
76°C

[ 分子式 ]:
C₁₁H₁₄O₃

[ 分子量 ]:
194.227

[ 闪点 ]:
125.4±13.2 °C

[ 精确质量 ]:
194.094299

[ PSA ]:
46.53000

[ LogP ]:
3.28

[ 外观性状 ]:
白色奶油色

[ 蒸汽压 ]:
0.0±0.7 mmHg at 25°C

[ 折射率 ]:
1.524

[ 储存条件 ]:
0-6°C

[ 水溶解性 ]:
可溶于：甲醇

尼泊金异丁酯MSDS

尼泊金异丁酯毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DH2247000

CHEMICAL NAME :: Benzoic acid, p-hydroxy-, isobutyl ester

CAS REGISTRY NUMBER :: 4247-02-3

BEILSTEIN REFERENCE NO. :: 2642305

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C11-H14-O3

MOLECULAR WEIGHT :: 194.25

WISWESSER LINE NOTATION :: QR DVO1Y1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2600 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 128,135,1960

尼泊金异丁酯安全信息

[ 符号 ]:

GHS07, GHS09

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H411

[ 警示性声明 ]:
P305 + P351 + P338

[ 危害码 (欧洲) ]:
Xn: Harmful;

[ 风险声明 (欧洲) ]:
51/53

[ 安全声明 (欧洲) ]:
S22-S24/25

[ 危险品运输编码 ]:
UN 3077 9/PG 3

[ RTECS号 ]:
DH2247000

[ 海关编码 ]:
2918290000

尼泊金异丁酯合成路线

尼泊金异丁酯上下游产品

尼泊金异丁酯上游产品

尼泊金异丁酯下游产品

尼泊金异丁酯制备

由对羟基苯甲酸与异丁醇酯化而得。酯化反应在硫酸存在下进行，以苯或甲苯为溶剂，加热回流反应，得到对羟基苯甲酸异丁酯。按《日本食品添加物公定书》规定，产品纯度应在99%以上。该品毒性较小，鼠口服LD50为8.38g/kg。

由对羟基苯甲酸与异丁醇在硫酸存在下，用苯或甲苯之类的共沸溶剂，加热回流而得。

尼泊金异丁酯海关

[ 海关编码 ]: 2918290000

[ 中文概述 ]:
2918290000 其他含酚基但不含其他含氧基羧酸及其酸酐、酰卤化物、过氧化物和过氧酸及它们的衍生物。监管条件:AB(入境货物通关单,出境货物通关单)。增值税率:17.0%。退税率:9.0%。最惠国关税:6.5%。普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ 监管条件 ]: A.入境货物通关单 B.出境货物通关单

[ 检验检疫 ]: R.进口食品卫生监督检验 S.出口食品卫生监督检验

[ Summary ]:
HS: 2918290000 other carboxylic acids with phenol function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) VAT:17.0% MFN tariff:6.5% General tariff:30.0%

尼泊金异丁酯文献

Determination and separation of bisphenol A, phthalate metabolites and structural isomers of parabens in human urine with conventional high-pressure liquid chromatography combined with electrospray ionisation tandem mass spectrometry.

Anal. Bioanal. Chem 407(9) , 2509-18, (2015)

Phthalates, bisphenol A (BPA) and parabens (PBs), organic chemicals widely used in everyday products, are considered to be endocrine disruptors. We propose a liquid chromatography-tandem mass spectrom...

Cosmetics-triggered percutaneous remote control of transgene expression in mice.

Nucleic Acids Res. 43 , e91, (2015)

Synthetic biology has significantly advanced the rational design of trigger-inducible gene switches that program cellular behavior in a reliable and predictable manner. Capitalizing on genetic compone...

Improved sensitivity gas chromatography-mass spectrometry determination of parabens in waters using ionic liquids.

Talanta 146 , 568-74, (2015)

A new procedure for the introduction of ionic liquid samples in gas chromatography (GC) is proposed. This procedure, based on microvial insert thermal desorption, allows the direct analysis of the com...

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