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苯丙香豆素

苯丙香豆素用途

Phenprocoumon 是香豆素衍生物,是一种长效口服抗凝剂和维生素 K (vitamin K) 的拮抗剂。

苯丙香豆素名称

[ CAS 号 ]:
435-97-2

[ 中文名 ]:
乙苄香豆

[ 英文名 ]:
Phenprocoumon

[中文别名 ]:

苯丙香豆素

[英文别名 ]:

Marcoumar
Phenprocumon
Marcumar
4-Hydroxy-3-(1-phenylpropyl)-2H-chromen-2-one
UNII:Q08SIO485D
Falithrom
Falithiom
Phenprocumone
3-(a-Ethylbenzyl)-4-hydroxycoumarin
RO 1-4849

苯丙香豆素生物活性

[ 描述 ]:

Phenprocoumon 是香豆素衍生物,是一种长效口服抗凝剂和维生素 K (vitamin K) 的拮抗剂。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 其他

[ 靶点 ]

Vitamin K[1].

[体内研究]

在单次iv剂量的苯丙香豆素(0.355mg/kg)后,获得的抗凝血作用在年龄大于年轻大鼠中更大。年轻和年老大鼠的消除率,分布容量以及血浆和肝脏中苯丙香豆素的游离分数和游离浓度值没有差异。静脉注射64.3μg/ kg [3H]维生素K1和不同剂量的phenprocoumon(0.02至3 mg/kg)后,肝脏中[3H]维生素K1浓度降低,[3H]维生素K1-2,3-环氧化物浓度的增加取决于phenprocoumon的剂量和肝脏浓度。这些变化在老年人中比在年轻老鼠中更明显[2]。

[参考文献]

[1]. Straubhaar B, et al. The prevalence of potential drug-drug interactions in patients with heart failure at hospital discharge. Drug Saf. 2006;29(1):79-90.

[2]. DIETMAR TRENK, et al. Age-dependent differences in the effect of phenprocoumon on the vitamin K1-epoxide cycle in rats. Trenk D. J Pharm Pharmacol. 1980 Dec;32(12):828-32.

[相关活性小分子]

苯丙香豆素物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
463.2±45.0 °C at 760 mmHg

[ 熔点 ]:
179.5ºC

[ 分子式 ]:
C₁₈H₁₆O₃

[ 分子量 ]:
280.318

[ 闪点 ]:
195.7±21.5 °C

[ 精确质量 ]:
280.109955

[ PSA ]:
50.44000

[ LogP ]:
4.77

[ 蒸汽压 ]:
0.0±1.2 mmHg at 25°C

[ 折射率 ]:
1.638

[ 储存条件 ]:
2-8℃

苯丙香豆素毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GN6769000

CHEMICAL NAME :: Coumarin, 3-(alpha-ethylbenzyl)-4-hydroxy-

CAS REGISTRY NUMBER :: 435-97-2

BEILSTEIN REFERENCE NO. :: 1291115

LAST UPDATED :: 199612

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C18-H16-O3

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC. Volume(issue)/page/year: 222,107,1954

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 190 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC. Volume(issue)/page/year: 222,107,1954

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 32 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC. Volume(issue)/page/year: 222,107,1954

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC. Volume(issue)/page/year: 222,107,1954

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 62 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC. Volume(issue)/page/year: 222,107,1954 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 13500 ug/kg/26W-I

TOXIC EFFECTS :: Blood - hemorrhage Blood - change in clotting factors Related to Chronic Data - death

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 21,145,1971

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 24900 ug/kg/52W-I

TOXIC EFFECTS :: Related to Chronic Data - death

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 21,145,1971

苯丙香豆素安全信息

[ 危险品运输编码 ]:
UN 2811

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1(b)

[ 海关编码 ]:
2932209090

苯丙香豆素合成路线

详细合成路线

苯丙香豆素上下游产品

苯丙香豆素上游产品

苯丙香豆素下游产品

苯丙香豆素海关

[ 海关编码 ]: 2932209090

[ 中文概述 ]:
2932209090. 其他内酯. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2932209090. other lactones. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%