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CK-666

CK-666用途

CK-666 是一种细胞渗透性的与肌动蛋白相关的蛋白质 Arp2/3 复合物的抑制剂,它结合 Arp2/3 复合物,稳定复合物的非活性状态,阻止 Arp2 和 Arp3 亚单位移动进入激活的丝状构象。

CK-666名称

[ CAS 号 ]:
442633-00-3

[ 英文名 ]:
CK 666

[英文别名 ]:

CK-666

CK-666生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 细胞骨架 >> Arp2/3复合物

研究领域 >> 其他

[ 靶点 ]

Arp2/3 complex[1]

[参考文献]

[1]. Hetrick B, et al. Small molecules CK-666 and CK-869 inhibit actin-related protein 2/3 complex by blocking an activating conformational change. Chem Biol. 2013 May 23;20(5):701-12.

CK-666物理化学性质

[ 分子式 ]:
C₁₈H₁₇FN₂O

[ 分子量 ]:
296.33900

[ 精确质量 ]:
296.13200

[ PSA ]:
48.38000

[ LogP ]:
4.16270

[ 储存条件 ]:
-20°C，密闭，干燥

CK-666安全信息

[ 危险品运输编码 ]:
NONH for all modes of transport

CK-666合成路线

详细合成路线

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CK-666文献

Essential role of endocytosis for interleukin-4-receptor-mediated JAK/STAT signalling.

J. Cell Sci. 128 , 3781-95, (2015)

Many important signalling cascades operate through specialized signalling endosomes, but a corresponding mechanism has as yet not been described for hematopoietic cytokine receptors. Based on live-cel...

Transcriptional regulation of Annexin A2 promotes starvation-induced autophagy.

Nat. Commun. 6 , 8045, (2015)

Autophagy is an important degradation pathway, which is induced after starvation, where it buffers nutrient deprivation by recycling macromolecules in organisms from yeast to man. While the classical ...

PI(3,5)P2 controls endosomal branched actin dynamics by regulating cortactin-actin interactions.

J. Cell Biol. 210 , 753-69, (2015)

Branched actin critically contributes to membrane trafficking by regulating membrane curvature, dynamics, fission, and transport. However, how actin dynamics are controlled at membranes is poorly unde...

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