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岩白菜素

岩白菜素用途

岩白菜素 (Bergenin) 是一种多酚类物质,具有抗氧化活性。在疟原虫活性中,IC50 < 2.5 μM。

岩白菜素名称

[ CAS 号 ]:
477-90-7

[ 中文名 ]:
岩白菜素

[ 英文名 ]:
Bergenin

[中文别名 ]:

[英文别名 ]:

Vakerin
Ai Cha Su
Bergenitol
Bergenit
Peltophorin
CORYLOPSIN
(+)-Bergenin
BERGENIN
CUSCUTIN
Ardisic Acid B

岩白菜素生物活性

[ 描述 ]:

岩白菜素 (Bergenin) 是一种多酚类物质,具有抗氧化活性。在疟原虫活性中,IC50 < 2.5 μM。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 其他

天然产物 >> 苯丙酸类

[参考文献]

[1]. Gao XJ, et al. Bergenin Plays an Anti-Inflammatory Role via the Modulation of MAPK and NF-κB Signaling Pathways in a Mouse Model of LPS-Induced Mastitis. Inflammation. 2015 Jun;38(3):1142-50.

[2]. Yun J, et al. Bergenin decreases the morphine-induced physical dependence via antioxidative activity in mice. Arch Pharm Res. 2015 Jun;38(6):1248-54.

[3]. Uddin G, et al. Comparative antioxidant and antiplasmodial activities of 11-O-galloylbergenin and bergenin isolated from Bergenia ligulata. Trop Biomed. 2014 Mar;31(1):143-8.

[相关活性小分子]

岩白菜素物理化学性质

[ 密度 ]:
1.6±0.1 g/cm3

[ 沸点 ]:
658.9±55.0 °C at 760 mmHg

[ 熔点 ]:
237-240 °C(lit.)

[ 分子式 ]:
C₁₄H₁₆O₉

[ 分子量 ]:
328.271

[ 闪点 ]:
250.7±25.0 °C

[ 精确质量 ]:
328.079437

[ PSA ]:
145.91000

[ LogP ]:
0.05

[ 外观性状 ]:
松白色针状晶体粉末或结晶

[ 蒸汽压 ]:
0.0±2.1 mmHg at 25°C

[ 折射率 ]:
1.655

[ 储存条件 ]:
?20°C

岩白菜素MSDS

详细MSDS(安全技术说明书)

岩白菜素安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 危害码 (欧洲) ]:
Xi: Irritant;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
UQ0337200

岩白菜素合成路线

详细合成路线

岩白菜素上下游产品

岩白菜素上游产品

岩白菜素下游产品

岩白菜素制备

1.以生药虎耳草科植物岩白菜为原料提取，具体工艺路线如下：

岩白菜素文献

Studies on the chemical constituents and anticancer activity of Saxifraga stolonifera (L) Meeb.

Bioorg. Med. Chem. 16 , 1337-44, (2008)

Saxifraga stolonifera, an evergreen dicotyledon, has been identified as an important resource in Chinese medicine due to its anticancer activity. In the present report, chemical components of S. stolo...

Simultaneous quantification of biomarkers bergenin and menisdaurin in the methanol extract of aerial parts of Flueggea virosa by validated HPTLC densitometric method.

J. Chromatogr. Sci. 53 , 824-9, (2015)

A simple, sensitive high-performance thin-layer chromatography (HPTLC) method was developed for the simultaneous quantification of biomarker bergenin and menisdaurin in the methanol extracts of aerial...

A novel lactone from Tripterospermum chinense.

Yao Xue Xue Bao 47(11) , 1517-20, (2012)

A novel lactone, tripterospermumcins E (1), along with four known compounds, sweroside (2), loganic acid (3), 8-epi-kingiside (4) and bergenin (5), were isolated from the aerial parts of Tripterosperm...

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