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胡桃酮，5-羟基对萘醌

胡桃酮，5-羟基对萘醌用途

Juglone是从黑胡桃 Juglans regia 中发现的的一种黄色染料,具有抗菌能力。

胡桃酮，5-羟基对萘醌名称

[ CAS 号 ]:
481-39-0

[ 中文名 ]:
5-羟基对萘醌

[ 英文名 ]:
Juglone

[中文别名 ]:

[英文别名 ]:

Nucin
Juglone
EINECS 207-567-5
5-Hydroxy-1,4-naphthalenedione
C.I. Natural Brown 7
5-hydroxynaphthalene-1,4-dione
Regianin
CI 75500
5-hydroxy-1,4-dihydronaphthalene-1,4-dione
5-Hydroxy-1,4-naphthochinone

胡桃酮，5-羟基对萘醌生物活性

[ 描述 ]:

Juglone是从黑胡桃 Juglans regia 中发现的的一种黄色染料,具有抗菌能力。

[ 相关类别 ]:

研究领域 >> 感染

信号通路 >> 抗感染 >> 细菌

[参考文献]

[1]. J. Johnson Inbaraj, et al. Cytotoxic Action of Juglone and Plumbagin: A Mechanistic Study Using HaCaT Keratinocytes.Chem. Res. Toxicol. 2004, 17, 1, 55-62

胡桃酮，5-羟基对萘醌物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 沸点 ]:
385.8±42.0 °C at 760 mmHg

[ 熔点 ]:
161-163 °C(lit.)

[ 分子式 ]:
C₁₀H₆O₃

[ 分子量 ]:
174.153

[ 闪点 ]:
201.3±24.4 °C

[ 精确质量 ]:
174.031693

[ PSA ]:
54.37000

[ LogP ]:
1.86

[ 外观性状 ]:
红色粉末

[ 蒸汽压 ]:
0.0±0.9 mmHg at 25°C

[ 折射率 ]:
1.662

[ 储存条件 ]:
Refrigerator (+4°C)

[ 水溶解性 ]:
SOLUBLE IN HOT WATER

胡桃酮，5-羟基对萘醌MSDS

胡桃酮，5-羟基对萘醌毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: QJ5775000

CHEMICAL NAME :: 1,4-Naphthalenedione, 5-hydroxy-

CAS REGISTRY NUMBER :: 481-39-0

BEILSTEIN REFERENCE NO. :: 1909764

LAST UPDATED :: 199706

DATA ITEMS CITED :: 8

MOLECULAR FORMULA :: C10-H6-O3

MOLECULAR WEIGHT :: 174.16

WISWESSER LINE NOTATION :: L66 BV EVJ GQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 112 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2500 ug/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity)

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 25 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 10 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 394 mg/kg/53W-I

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Skin and Appendages - tumors

TYPE OF TEST :: Sex chromosome loss and nondisjunction

MUTATION DATA

TYPE OF TEST :: Mutation test systems - not otherwise specified

TEST SYSTEM :: Rodent - mouse Ascites tumor

DOSE/DURATION :: 10 mg/kg

REFERENCE :: PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 126,583,1967

胡桃酮，5-羟基对萘醌安全信息

[ 符号 ]:

GHS06, GHS09

[ 信号词 ]:
Danger

[ 危害声明 ]:
H301-H315-H319-H335-H400

[ 警示性声明 ]:
P261-P273-P301 + P310-P305 + P351 + P338

[ 个人防护装备 ]:
Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
T:Toxic;

[ 风险声明 (欧洲) ]:
R25;R36/37/38

[ 安全声明 (欧洲) ]:
S22-S26-S36/37/39-S45-S37/39-S28A

[ 危险品运输编码 ]:
UN 2811 6.1/PG 3

[ WGK德国 ]:
3

[ RTECS号 ]:
QJ5775000

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1

[ 海关编码 ]:
2914690090

胡桃酮，5-羟基对萘醌合成路线

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胡桃酮，5-羟基对萘醌制备

胡桃醌作为氢化胡桃醌（三羟基萘）的苷存在于胡桃科植物胡桃及其同属植物黑核桃的未成熟的外果皮（青皮）中。可从天然物质中分离，也可化学合成。

胡桃酮，5-羟基对萘醌海关

[ 海关编码 ]: 2914690090

[ 中文概述 ]:
2914690090 其他醌. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:5.5% 普通关税:30.0%

[ Summary ]:
2914690090 other quinones。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

胡桃酮，5-羟基对萘醌文献

Redox effects and cytotoxic profiles of MJ25 and auranofin towards malignant melanoma cells.

Oncotarget 6 , 16488-506, (2015)

Malignant melanoma is the most dangerous type of skin cancer. Although recent progress in treatment has been achieved, lack of response, drug resistance and relapse remain major problems. The tumor su...

Chromatographic evaluation and QSAR optimization for benzoic acid analogues against carbonic anhydrase III.

J. Enzyme Inhib. Med. Chem. 30 , 420-9, (2015)

An HPLC-size exclusion method was developed as an assay method to evaluate the binding of tested compounds with carbonic anhydrase III (CAIII) enzyme. Inhibition of CAIII by a group of benzoic acid an...

Determination of the Juglone Content of Juglans regia Leaves by GC/MS.

Nat. Prod. Commun. 10 , 1239-42, (2015)

The constituents of walnut (Juglans regia L.) leaves are represented by tannins, phenolics, and naphthoquinones, the characteristic compound being juglone. The content of juglone in the methanolic ext...

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