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芒柄花黄素

芒柄花黄素用途

Formononetin (Formononetol; Flavosil)提取自红三叶草,能剂量依赖的抑制DU-145/PC-3细胞增殖。

芒柄花黄素名称

[ CAS 号 ]:
485-72-3

[ 中文名 ]:
刺芒柄花素

[ 英文名 ]:
Formononetin

[中文别名 ]:

[英文别名 ]:

7-hydroxy-4'-methoxy-Isoflavone (8CI)
7-Hydroxy-3-(4-methoxyphenyl)-4H-chromen-4-one
Formononetol
4'-O-methyl-daidzein
BIOCHANIN B
ForMonentin
BIOCHANIN A
Flavosil
7-Hydroxy-4'-methoxyisoflavone
Neochanin

芒柄花黄素生物活性

[ 描述 ]:

Formononetin (Formononetol; Flavosil)提取自红三叶草,能剂量依赖的抑制DU-145/PC-3细胞增殖。

[ 相关类别 ]:

天然产物 >> 黄酮类化合物

研究领域 >> 癌症

[参考文献]

[1]. Liu XJ, et al. Up-regulating of RASD1 and apoptosis of DU-145 human prostate cancer cells induced by formononetin in vitro. Asian Pac J Cancer Prev. 2014;15(6):2835-9.

[2]. Zhang X, et al. Formononetin induces apoptosis in PC-3 prostate cancer cells through enhancing the Bax/Bcl-2 ratios and regulating the p38/Akt pathway. Nutr Cancer. 2014;66(4):656-61.

[3]. Chen J, et al. Formononetin induces cell cycle arrest of human breast cancer cells via IGF1/PI3K/Akt pathways in vitro and in vivo. Horm Metab Res. 2011 Sep;43(10):681-6.

[相关活性小分子]

芒柄花黄素物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
479.4±45.0 °C at 760 mmHg

[ 熔点 ]:
256-260 °C

[ 分子式 ]:
C₁₆H₁₂O₄

[ 分子量 ]:
268.264

[ 闪点 ]:
183.4±22.2 °C

[ 精确质量 ]:
268.073547

[ PSA ]:
59.67000

[ LogP ]:
2.96

[ 外观性状 ]:
灰白色粉末

[ 蒸汽压 ]:
0.0±1.2 mmHg at 25°C

[ 折射率 ]:
1.641

[ 储存条件 ]:
Refrigerator

芒柄花黄素MSDS

详细MSDS(安全技术说明书)

芒柄花黄素安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P280-P305 + P351 + P338-P337 + P313

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi:Irritant

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S37/39-S26-S36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ 海关编码 ]:
2932999099

芒柄花黄素合成路线

详细合成路线

芒柄花黄素上下游产品

芒柄花黄素上游产品

芒柄花黄素下游产品

芒柄花黄素海关

[ 海关编码 ]: 2932999099

[ 中文概述 ]:
2932999099. 其他仅含氧杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

芒柄花黄素文献

Flavonoids as a scaffold for development of novel anti-angiogenic agents: An experimental and computational enquiry.

Arch. Biochem. Biophys. 577-578 , 35-48, (2015)

Relationship between structural diversity and biological activities of flavonoids has remained an important discourse in the mainstream of flavonoid research. In the current study anti-angiogenic, cyt...

Preparation and evaluation of surface-bonded tricationic ionic liquid silica as stationary phases for high-performance liquid chromatography.

J. Chromatogr. A. 1396 , 62-71, (2015)

Two tricationic ionic liquids were prepared and then bonded onto the surface of supporting silica materials through "thiol-ene" click chemistry as new stationary phases for high-performance liquid chr...

Sodium Hydroxide Enhances Extractability and Analysis of Proanthocyanidins in Ensiled Sainfoin (Onobrychis viciifolia).

J. Agric. Food Chem. 63 , 9471-9, (2015)

Little information exists on the effects of ensiling on condensed tannins or proanthocyanidins. The acetone-butanol-HCl assay is suitable for measuring proanthocyanidin contents in a wide range of sam...

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