N-(4-甲氧基苄基)-N'-(5-硝基-1,3-噻唑-2-基)脲
用途
名称
[ CAS 号 ]:
487021-52-3
[ 中文名 ]:
N-(4-甲氧基苄基)-N'-(5-硝基-1,3-噻唑-2-基)脲
[ 英文名 ]:
AR-A014418
[英文别名 ]:
- 1q5k
- GSK-3beta Inhibitor VIII
- Kinome_1268
- AR-A014418
- GSK-3β Inhibitor VIII
- 1-(4-Methoxybenzyl)-3-(5-nitrothiazol-2-yl)urea
生物活性
[ 描述 ]:
[ 相关类别 ]:
[ 靶点 ]
GSK-3β:104 nM (IC50)
[体外研究]
[体内研究]
[激酶实验]
[细胞实验]
[动物实验]
[参考文献]
[相关活性小分子]
物理化学性质
[ 密度 ]:
1.5±0.1 g/cm3
[ 熔点 ]:
208-210?C (dec.)
[ 分子式 ]:
C12H12N4O4S
[ 分子量 ]:
308.313
[ 精确质量 ]:
308.057922
[ PSA ]:
137.31000
[ LogP ]:
1.43
[ 外观性状 ]:
off-white to tan
[ 折射率 ]:
1.666
[ 储存条件 ]:
2-8°C
[ 水溶解性 ]:
DMSO: ≥20mg/mL, clear, light yellow
安全信息
[ 符号 ]:
GHS05, GHS07
[ 信号词 ]:
Danger
[ 危害声明 ]:
H302-H315-H318-H335
[ 警示性声明 ]:
P261-P280-P305 + P351 + P338
[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves
[ 危害码 (欧洲) ]:
Xn
[ 风险声明 (欧洲) ]:
22-37/38-41
[ 安全声明 (欧洲) ]:
26-36/39
[ 危险品运输编码 ]:
NONH for all modes of transport
文献
Neurobiol. Aging 36(1) , 211-27, (2014)
It is well established that mitochondrial fragmentation plays a key role in the pathogenesis of Alzheimer's disease (AD). Mitochondrial fission is mediated by dynamin-related protein 1 (Drp1), which i...
Thr175-phosphorylated tau induces pathologic fibril formation via GSK3β-mediated phosphorylation of Thr231 in vitro.Neurobiol. Aging 36 , 1590-9, (2015)
We have previously shown that amyotrophic lateral sclerosis with cognitive impairment can be characterized by pathologic inclusions of microtubule-associated protein tau (tau) phosphorylated at Thr(17...
Signal transducers and activators of transcription 3-induced metastatic potential in gastric cancer cells is enhanced by glycogen synthase kinase-3β.APMIS 123 , 373-82, (2015)
The transcription factor signal transducers and activators of transcription 3 (STAT3) can promote cancer metastasis, but its underlying regulatory mechanisms in gastric cancer cell invasiveness still ...
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产品详情:1-(4-甲氧基苄基)-3-(5-硝基噻唑-2-基)脲
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¥592.0/10mg
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相关化合物
CAS号[487021-52-3]化源网提供[N-(4-甲氧基苄基)-N'-(5-硝基-1,3-噻唑-2-基)脲]MSDS、说明、性质、英文名、生产厂家、作用/用途、分子量、密度、沸点、熔点、结构式等。>>电脑版:N-(4-甲氧基苄基)-N'-(5-硝基-1,3-噻唑-2-基)脲
标题:487021-52-3_CAS号:487021-52-3_N-(4-甲氧基苄基)-N'-(5-硝基-1,3-噻唑-2-基)脲 - 化源网 地址:https://www.chemsrc.com/amp/cas/487021-52-3_754082.html