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愈创奥

愈创奥用途

Guaiazulene 存在于几种药用植物和芳香植物精油中,具有抗氧化活性。Guaiazulene 对神经元和 N2a-NB 细胞具有体外细胞毒活性。

愈创奥名称

[ CAS 号 ]:
489-84-9

[ 中文名 ]:
愈创奥

[ 英文名 ]:
guaiazulene

[中文别名 ]:

[英文别名 ]:

1,4-Dimethyl-7-(propan-2-yl)azulen
Guajazulene
Azulene, 1,4-dimethyl-7-(1-methylethyl)-
1,4-dimethyl-7-propan-2-ylazulene
Cuteazul
Gurjunazulen
Eucazulen
Vetivazulen
Azulon
Vaumigan

愈创奥生物活性

[ 描述 ]:

Guaiazulene 存在于几种药用植物和芳香植物精油中,具有抗氧化活性。Guaiazulene 对神经元和 N2a-NB 细胞具有体外细胞毒活性。

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

[参考文献]

[1]. Kourounakis AP, et al. Antioxidant activity of guaiazulene and protection against paracetamol hepatotoxicity in rats. J Pharm Pharmacol. 1997 Sep;49(9):938-42.

[2]. Togar B, et al. Guaiazulene biochemical activity and cytotoxic and genotoxic effects on rat neuron and N2a neuroblastom cells. J Intercult Ethnopharmacol. 2015 Jan-Mar;4(1):29-33.

愈创奥物理化学性质

[ 密度 ]:
0.976

[ 沸点 ]:
305.4±22.0 °C at 760 mmHg

[ 熔点 ]:
27-29 °C(lit.)

[ 分子式 ]:
C₁₅H₁₈

[ 分子量 ]:
198.303

[ 闪点 ]:
142.3±13.1 °C

[ 精确质量 ]:
198.140854

[ LogP ]:
5.71

[ 外观性状 ]:
暗蓝色固体

[ 蒸汽压 ]:
0.0±0.3 mmHg at 25°C

[ 折射率 ]:
1.573

[ 储存条件 ]:
2-8°C

愈创奥MSDS

详细MSDS(安全技术说明书)

愈创奥毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CO4790000

CHEMICAL NAME :: Azulene, 1,4-dimethyl-7-isopropyl-

CAS REGISTRY NUMBER :: 489-84-9

BEILSTEIN REFERENCE NO. :: 1365001

LAST UPDATED :: 199701

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C15-H18

MOLECULAR WEIGHT :: 198.33

WISWESSER LINE NOTATION :: L57J B1 F1 IY1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1550 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 19,615,1969

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1220 mg/kg

TOXIC EFFECTS :: Behavioral - ataxia Lungs, Thorax, or Respiration - dyspnea Gastrointestinal - hypermotility, diarrhea

REFERENCE :: NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 54,362,1958

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 525 mg/kg

TOXIC EFFECTS :: Peripheral Nerve and Sensation - spastic paralysis with or without sensory change Behavioral - ataxia Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 54,362,1958

愈创奥安全信息

[ 危害码 (欧洲) ]:
Xn:Harmful;

[ 风险声明 (欧洲) ]:
R22

[ 安全声明 (欧洲) ]:
S36/37/39-S26-S22

[ WGK德国 ]:
3

[ RTECS号 ]:
CO4790000

愈创奥上下游产品

愈创奥上游产品

愈创奥下游产品

愈创奥制备

提取蓝樟油（馏程220～300℃）通入氮气与钯  碳试剂，沸腾反应5h，滤出的油料中加入石油醚和80%磷酸。酸层用石油醚洗涤后，加入多量冰水，用石油醚萃取。有机相用2%氢氧化钠和水洗涤后，浓缩产物为愈创木奥粗品，得率以蓝樟油计为8%。

愈创奥