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乙基麦芽酚

乙基麦芽酚用途

Ethyl maltol (2-Ethyl-3-hydroxy-4H-pyran-4-one) 是一种具有气味的活性物。

乙基麦芽酚名称

[ CAS 号 ]:
4940-11-8

[ 中文名 ]:
乙基麦芽酚

[ 英文名 ]:
Ethyl maltol

[中文别名 ]:

[英文别名 ]:

2-Ethyl-3-hydroxy-4-pyrone
EINECS 225-582-5
2-Ethyl-3-hydroxy-4H-pyran-4-one
MFCD00059795
2-Ethyl pyromeconic acid
4H-Pyran-4-one, 2-ethyl-3-hydroxy-
Ethyl maltol
Veltol plus

乙基麦芽酚生物活性

[ 描述 ]:

Ethyl maltol (2-Ethyl-3-hydroxy-4H-pyran-4-one) 是一种具有气味的活性物。

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

[参考文献]

[1]. Niu Y, et al. Characterization of odor-active compounds of various cherry wines by gas chromatography-mass spectrometry, gas chromatography-olfactometry and their correlation with sensory attributes. J Chromatogr B Analyt Technol Biomed Life Sci. 2011 Aug 1;879(23):2287-93.

乙基麦芽酚物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
290.3±40.0 °C at 760 mmHg

[ 熔点 ]:
85-95 °C(lit.)

[ 分子式 ]:
C₇H₈O₃

[ 分子量 ]:
140.137

[ 闪点 ]:
124.8±20.8 °C

[ 精确质量 ]:
140.047348

[ PSA ]:
50.44000

[ LogP ]:
0.61

[ 外观性状 ]:
白色结晶粉末

[ 蒸汽压 ]:
0.0±1.4 mmHg at 25°C

[ 折射率 ]:
1.541

[ 储存条件 ]:
室温，干燥，密封

[ 水溶解性 ]:
水溶性：可溶；可溶于：氯仿,醇,甲苯

乙基麦芽酚MSDS

乙基麦芽酚毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UQ0840000

CHEMICAL NAME :: 4H-Pyran-4-one, 2-ethyl-3-hydroxy-

CAS REGISTRY NUMBER :: 4940-11-8

BEILSTEIN REFERENCE NO. :: 1618110

LAST UPDATED :: 199712

DATA ITEMS CITED :: 9

MOLECULAR FORMULA :: C7-H8-O3

MOLECULAR WEIGHT :: 140.15

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1150 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 780 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 910 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - chicken

DOSE/DURATION :: 1270 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 90 gm/kg/90D-I

TOXIC EFFECTS :: Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis)

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Salmonella typhimurium

DOSE/DURATION :: 2 mg/plate

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 67,367,1979 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - T2072 No. of Facilities: 193 (estimated) No. of Industries: 6 No. of Occupations: 8 No. of Employees: 4632 (estimated) No. of Female Employees: 1504 (estimated)

乙基麦芽酚安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302

[ 警示性声明 ]:
P301 + P312 + P330

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn:Harmful

[ 风险声明 (欧洲) ]:
R22

[ 安全声明 (欧洲) ]:
S36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
UQ0840000

[ 海关编码 ]:
2932999099

乙基麦芽酚合成路线

乙基麦芽酚上下游产品

乙基麦芽酚上游产品

乙基麦芽酚下游产品

乙基麦芽酚制备

主要有发酵法、糖醇氯化法和糖醛法。1.发酵法由淀粉发酵得到麯酸，再经醚化、氧化、脱苄、脱羧、羟基化、还原而得乙基麦牙酚。2.糖醇氯化法糖醇用氯气氧化（或用次氯酸钠氧化），加热分解得焦糖酸，然后与乙醛反应，还原得乙基麦芽酚。3.糖醛法以糠醛为原料与乙基格氏试剂反应制得糠基丙酮，再用氯气氧化，然后水解制取乙基麦芽酚。

由淀粉发酵制成曲酸，然后再合成而得。
由糠醛或糠醇合成而成。

糠醇法
糠醇在甲醇水溶液中经通人氯气氯化生成4-氯代-6-羟基-2[H]-吡喃-3[6H]-酮，然后加热水解得焦袂康酸；在碱性条件下焦袂康酸与乙醛缩合得羟乙基焦袂康酸，在盐酸中用锌粉将其还原为乙基麦芽酚。糠醛法
糠醛与乙基溴化镁作用得到乙基糠醇，然后在甲醇水溶液中、0℃下通氯气氧化，接着加热至100℃水解得乙基麦芽酚。此法原料来源广、路线短、工艺条件温和、设备简单、三废少，有较好的发展前景。半合成法
以淀粉为原料，经犁头霉发酵制得曲酸；曲酸与氯化苄在氢氧化钠-甲醇溶液中醚化生成曲酸苄醚；然后用二氧化锰氧化成考门酸苄醚，并在盐酸存在下脱苄生成考门酸；再经脱羧成为焦袂康酸，最后与乙醛缩合，并用锌粉还原成麦芽酚。

乙基麦芽酚海关

[ 海关编码 ]: 2932999099

[ 中文概述 ]:
2932999099. 其他仅含氧杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

乙基麦芽酚文献

Perceptual blending in odor mixtures depends on the nature of odorants and human olfactory expertise.

Chem. Senses 37(2) , 159-66, (2012)

Our olfactory system is confronted with complex mixtures of odorants, often recognized as single entities due to odor blending (e.g., coffee). In contrast, we are also able to discriminate odors from ...

Vanadium treatment of type 2 diabetes: A view to the future

J. Inorg. Biochem. 103(4) , 554-8, (2009)

3-Hydroxy-2-methyl-4-pyrone and 2-ethyl-3-hydroxy-4-pyrone (maltol and ethyl maltol, respectively) have proven especially suitable as ligands for vanadyl ions, in potential insulin enhancing agents fo...

Reversed-phase high-performance liquid chromatography of non-transferrin-bound iron and some hydroxypyridone and hydroxypyrone chelators.

J. Chromatogr. B, Biomed. Appl. 658(1) , 121-7, (1994)

The pursuit of orally available Fe(III) chelating agents has resulted in several clinical trials of 1,2-dimethyl-3-hydroxypyrid-4-one (CP20). Chromatography of this and related Fe chelators on silica-...

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