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对羟基苯丙酸

对羟基苯丙酸用途

Desaminotyrosine 是一种微生物相关的代谢物,通过扩大 I 型干扰素 (type I interferon) 信号来阻止 influenza 的发生。

对羟基苯丙酸名称

[ CAS 号 ]:
501-97-3

[ 中文名 ]:
对羟基苯丙酸

[ 英文名 ]:
Desaminotyrosine

[中文别名 ]:

[英文别名 ]:

Benzenepropanoic acid, 4-hydroxy-
4-hydroxy-benzenepropanoic acid
MFCD00002778
3-(p-hydroxyphenyl)propionic acid
4-Hydroxyhydrocinnamic Acid
3-(4-Hydroxyphenyl)propanoic acid
Phloretic acid
3-(p-Hydroxyphenyl)propionic acid,Phloretic acid
3-(para-Hydroxyphenyl)propionic acid
3-(4-Hydroxyphenyl)-propionic acid

对羟基苯丙酸生物活性

[ 描述 ]:

Desaminotyrosine 是一种微生物相关的代谢物,通过扩大 I 型干扰素 (type I interferon) 信号来阻止 influenza 的发生。

[ 相关类别 ]:

信号通路 >> 抗感染 >> 流感病毒

研究领域 >> 感染

天然产物 >> 糖和糖苷

[ 靶点 ]

Human Endogenous Metabolite

[体内研究]

野生型小鼠每克粪便产生纳摩尔的Desaminotyrosine,血清中含有皮摩尔量的Desaminotyrosine。在流感感染之前的脱氨基酪氨酸(200mM)治疗通过I型干扰素(IFN)信号传导来预防流感,对于具有或不具有万古霉素,新霉素,氨苄青霉素和甲硝唑(VNAM)的小鼠的体重减轻或存活没有影响。 Desaminotyrosine通过小鼠中的I型IFN扩增增强巨噬细胞中的I型IFN [1]。

[动物实验]

小鼠[1]指示的小鼠在饮用水中接受溶解在Kool-Aid中的200mM脱氨基酪氨酸（对照动物单独接受Kool-Aid）。指示小鼠接受万古霉素，新霉素，氨苄青霉素和甲硝唑（VNAM）治疗小鼠1mg / kg的聚（IC）注射，或每天腹膜内注射所有其他小鼠5mg / kg，持续4天，然后小鼠在第5天被瘢痕化此时收集血清[1]。

[参考文献]

[1]. Steed AL, et al. The microbial metabolite desaminotyrosine protects from influenza through type I interferon. Science. 2017 Aug 4;357(6350):498-502.

[相关活性小分子]

对羟基苯丙酸物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
352.4±17.0 °C at 760 mmHg

[ 熔点 ]:
129-131 °C(lit.)

[ 分子式 ]:
C₉H₁₀O₃

[ 分子量 ]:
166.174

[ 闪点 ]:
181.1±17.4 °C

[ 精确质量 ]:
166.062988

[ PSA ]:
57.53000

[ LogP ]:
1.10

[ 外观性状 ]:
灰白-黄色晶体

[ 蒸汽压 ]:
0.0±0.8 mmHg at 25°C

[ 折射率 ]:
1.580

[ 储存条件 ]:
2-8°C

[ 水溶解性 ]:
slightly soluble

对羟基苯丙酸MSDS

详细MSDS(安全技术说明书)

对羟基苯丙酸毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MW5342000

CHEMICAL NAME :: Hydrocinnamic acid, p-hydroxy-

CAS REGISTRY NUMBER :: 501-97-3

BEILSTEIN REFERENCE NO. :: 2209841

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C9-H10-O3

MOLECULAR WEIGHT :: 166.19

WISWESSER LINE NOTATION :: QV2R DQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1809 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - effect, not otherwise specified Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 12,265,1976

对羟基苯丙酸安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi:Irritant

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36-S37/39

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
MW5342000

[ 海关编码 ]:
2916399090

对羟基苯丙酸合成路线

详细合成路线

对羟基苯丙酸上下游产品

对羟基苯丙酸上游产品

对羟基苯丙酸下游产品

对羟基苯丙酸制备

1. 烟草：FC，54。

对羟基苯丙酸海关

[ 海关编码 ]: 2918290000

[ 中文概述 ]:
2918290000 其他含酚基但不含其他含氧基羧酸及其酸酐、酰卤化物、过氧化物和过氧酸及它们的衍生物。监管条件:AB(入境货物通关单,出境货物通关单)。增值税率:17.0%。退税率:9.0%。最惠国关税:6.5%。普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ 监管条件 ]: A.入境货物通关单 B.出境货物通关单

[ 检验检疫 ]: R.进口食品卫生监督检验 S.出口食品卫生监督检验

[ Summary ]:
HS: 2918290000 other carboxylic acids with phenol function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) VAT:17.0% MFN tariff:6.5% General tariff:30.0%

对羟基苯丙酸文献

Hydroxycinnamic acids used as external acceptors of electrons: an energetic advantage for strictly heterofermentative lactic acid bacteria.

Appl. Environ. Microbiol. 80(24) , 7574-82, (2014)

The metabolism of hydroxycinnamic acids by strictly heterofermentative lactic acid bacteria (19 strains) was investigated as a potential alternative energy route. Lactobacillus curvatus PE5 was the mo...

A metabolite profiling approach to identify biomarkers of flavonoid intake in humans.

J. Nucl. Med. 139 , 2309-14, (2009)

Flavonoids are phytochemicals that are widespread in the human diet. Despite limitations in their bioavailability, experimental and epidemiological data suggest health benefits of flavonoid consumptio...

Development of a targeted method for twenty-three metabolites related to polyphenol gut microbial metabolism in biological samples, using SPE and UHPLC-ESI-MS/MS.

Talanta 128 , 221-30, (2014)

An increasing number of studies have concerned the profiling of polyphenol microbial metabolites, especially in urine or plasma, but only a few have regarded their accurate quantification. This study ...

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